International Journal of Environmental Research and Public Health,
Год журнала:
2022,
Номер
19(2), С. 638 - 638
Опубликована: Янв. 6, 2022
Deltamethrin
(DLM)
is
a
synthetic
pyrethroid
with
anti-acaricide
and
insecticidal
properties.
It
commonly
used
in
agriculture
veterinary
medicine.
Humans
animals
are
exposed
to
DLM
through
the
ingestion
of
polluted
food
water,
resulting
severe
health
issues.
N-acetylcysteine
(NAC)
prodrug
L-cysteine,
precursor
glutathione.
can
restore
oxidant-antioxidant
balance.
Therefore,
this
research
aimed
examine
whether
NAC
may
protect
broiler
chickens
against
oxidative
stress,
at
level
biochemical
molecular
alterations
caused
by
intoxication.
The
indicators
liver
kidney
injury
serum
DLM-intoxicated
NAC-treated
groups
were
examined.
Furthermore,
lipid
peroxidation,
antioxidant
markers,
superoxide
dismutase
activity,
apoptotic
gene
expressions
(caspase-3
Bcl-2)
investigated.
All
parameters
significantly
altered
group,
suggesting
that
could
induce
damage
apoptosis
hepato-renal
tissue.
majority
changes
studied
reversed
when
therapy
was
used.
In
conclusion,
virtue
its
antiapoptotic
properties,
enabled
provision
significant
protection
effects
DLM-induced
injury.
Journal of Agricultural and Food Chemistry,
Год журнала:
2024,
Номер
72(28), С. 15985 - 15997
Опубликована: Июль 3, 2024
Liver
disease
has
become
an
important
risk
factor
for
global
health.
Resveratrol
(Res)
is
a
natural
polyphenol
which
widely
found
in
foods
and
variety
of
biological
activities.
This
study
investigated
the
role
microbiota-gut-liver
axis
Res
relieving
liver
fibrosis
induced
by
inorganic
mercury
exposure.
Twenty-eight
mice
were
divided
into
four
groups
(n
=
7)
treated
with
mercuric
chloride
and/or
24
weeks,
respectively.
The
results
showed
that
mitigated
ileum
injury
restrained
LPS
alcohol
entering
body
circulation.
Network
pharmacological
molecular
analyses
alleviated
oxidative
stress,
metabolism
disorders,
inflammation,
hepatic
stellate
cell
activation
liver.
In
conclusion,
alleviates
via
activating
Sirt1/PGC-1α
signaling
pathway
regulating
microbial-gut-liver
axis,
particularly,
increasing
relative
enrichment
Bifidobacterium
intestinal
tract.
International Journal of Environmental Research and Public Health,
Год журнала:
2022,
Номер
19(2), С. 638 - 638
Опубликована: Янв. 6, 2022
Deltamethrin
(DLM)
is
a
synthetic
pyrethroid
with
anti-acaricide
and
insecticidal
properties.
It
commonly
used
in
agriculture
veterinary
medicine.
Humans
animals
are
exposed
to
DLM
through
the
ingestion
of
polluted
food
water,
resulting
severe
health
issues.
N-acetylcysteine
(NAC)
prodrug
L-cysteine,
precursor
glutathione.
can
restore
oxidant-antioxidant
balance.
Therefore,
this
research
aimed
examine
whether
NAC
may
protect
broiler
chickens
against
oxidative
stress,
at
level
biochemical
molecular
alterations
caused
by
intoxication.
The
indicators
liver
kidney
injury
serum
DLM-intoxicated
NAC-treated
groups
were
examined.
Furthermore,
lipid
peroxidation,
antioxidant
markers,
superoxide
dismutase
activity,
apoptotic
gene
expressions
(caspase-3
Bcl-2)
investigated.
All
parameters
significantly
altered
group,
suggesting
that
could
induce
damage
apoptosis
hepato-renal
tissue.
majority
changes
studied
reversed
when
therapy
was
used.
In
conclusion,
virtue
its
antiapoptotic
properties,
enabled
provision
significant
protection
effects
DLM-induced
injury.
