Glyphosate exposure modulates lipid composition, histo-architecture and oxidative stress status and induces neurotoxicity in the smooth scallop Flexopecten glaber

Pesticide Biochemistry and Physiology, Год журнала: 2022, Номер 184, С. 105099 - 105099

Опубликована: Апрель 16, 2022

Язык: Английский

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Long-term stability of diclofenac and 4-hydroxydiclofenac in the seawater and sediment microenvironments: Evaluation of biotic and abiotic factors

Environmental Pollution, Год журнала: 2022, Номер 304, С. 119243 - 119243

Опубликована: Апрель 2, 2022

Язык: Английский

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A multi-biomarker approach to assess toxicity of diclofenac and 4-OH diclofenac in Mytilus trossulus mussels - First evidence of diclofenac metabolite impact on molluscs

Environmental Pollution, Год журнала: 2022, Номер 315, С. 120384 - 120384

Опубликована: Окт. 9, 2022

Although the presence of pharmaceuticals in environment is an issue widely addressed research over past two decades, still little known about their transformation products. However, there are indications that some these chemicals may be equally or even more harmful than parent compounds. Diclofenac (DCF) among most commonly detected aquatic environment, but potential effects its metabolites on organisms poorly understood. Therefore, present study aimed to evaluate and compare toxicity DCF metabolite, 4-hydroxy diclofenac (4-OH DCF), mussels using a multi-biomarker approach. Mytilus trossulus were exposed 4-OH at 68.22 20.85 μg/L (measured concentrations day 0), respectively, for 7 days. In our work, we showed both tested compounds have no effect enzymatic biomarkers tested. it has been shown action can affect protein content gills also reflected through histological markers. ENVIRONMENTAL IMPLICATION: Studies recent years clearly prove negatively organisms. addition compounds, significant environmental problem. main diclofenac, marine evaluated. Both negative mussels, which was primarily observed changes. The therefore confirms not only metabolite

Язык: Английский

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Behavioral, physiological and biochemical responses and differential gene expression in Mytilus galloprovincialis exposed to 17 alpha-ethinylestradiol and sodium lauryl sulfate

Journal of Hazardous Materials, Год журнала: 2021, Номер 426, С. 128058 - 128058

Опубликована: Дек. 10, 2021

Язык: Английский

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Effects of Diclofenac on the Reproductive Health, Respiratory Rate, Cardiac Activity, and Heat Tolerance of Aquatic Animals

Environmental Toxicology and Chemistry, Год журнала: 2021, Номер 41(3), С. 677 - 686

Опубликована: Дек. 21, 2021

Diclofenac is an important pharmaceutical present in the water cycle of wastewater treatment and one most distributed drugs aquatic ecosystems. Despite great interest fate diclofenac freshwaters, effects environmentally relevant concentrations on invertebrates are still unclear. Two species freshwater invertebrates, amphipod Gmelinoides fasciatus bivalve mollusk Unio pictorum, were exposed to 0.001-2 μg/L (environmentally levels) for 96 h. A set biological endpoints (survival, fecundity, embryo abnormalities, respiration heart rates, heat tolerance, cardiac stress tolerance) estimated invertebrates. Effects metabolic rate reproduction (number state embryos) adaptive capacity (cardiac both evident. The oxygen consumption amphipods 0.1-2 was 1.5-2 times higher than control, indicating increased energy requirements standard metabolism presence (>0.1 μg/L). recovery time mollusks after heating critical temperature (30 °C) 1.7 9 greater 0.1 0.9 μg/L, respectively, control (24 min). level >0.9 adversely affected embryos, leading increase number embryos with impaired development, which subsequently died. Thus, lowest effective concentration (0.1 μg/L) led demands animals while reducing at a close 1 reproductive disorders (elevated mortality occurred. Environ Toxicol Chem 2022;41:677-686. © 2021 SETAC.

Язык: Английский

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Improved selectivity of molecularly imprinted polymers based on the synergistic action of hydrogen bond and electrostatic interaction

Journal of Molecular Recognition, Год журнала: 2023, Номер 36(7)

Опубликована: Май 10, 2023

Abstract Based on the synergistic action of hydrogen bond and electrostatic interaction, provided by methacrylic acid 2‐aminoethyl ester hydrochloride (FM2), respectively, novel molecularly imprinted polymers (SA‐MIPs) were designed to improve its selective recognition ability. Diclofenac sodium (DFC) was chosen as template molecule this study. The interaction their sites between two functional monomers templates confirmed nuclear magnetic resonance spectroscopy. Because imprinting factor (IF) SA‐MIPs (IF = 2.26) is superior corresponding monofunctional monomer materials 1.52, 1.20) using with an only single type 1.54, 1.75). results adsorption experiments indicate that ability significantly better than other four MIPs, difference in selectivity coefficient for methyl orange largest MIPs FM2, which about 70 times. In addition, x‐ray photoelectron spectroscopy used verify template. This work explanation mechanism at molecular level will be helpful rational design higher selectivity. Besides, have good performance (37.75 mg/g) DFC aqueous solutions, could potential effective removal aquatic environment.

Язык: Английский

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Reduction in reproductive activity from degeneration of testicular follicles in Megapitaria squalida (Mollusca: Bivalvia) exposed to metal pollution in the Gulf of California

Marine Pollution Bulletin, Год журнала: 2024, Номер 205, С. 116648 - 116648

Опубликована: Июнь 24, 2024

Язык: Английский

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Biochemical and respiratory parameters in a gastropod Radix balthica exposed to diclofenac

Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology, Год журнала: 2021, Номер 252, С. 109240 - 109240

Опубликована: Ноя. 6, 2021

Язык: Английский

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Exposure of Mytilus trossulus to diclofenac and 4′-hydroxydiclofenac: Uptake, bioconcentration and mass balance for the evaluation of their environmental fate

The Science of The Total Environment, Год журнала: 2021, Номер 791, С. 148172 - 148172

Опубликована: Июнь 1, 2021

Diclofenac (DIC) is one of the most widely consumed drugs in world, and its presence environment as well potential effects on organisms are subject numerous recent scientific works. However, it becoming clear that risk posed by pharmaceuticals needs to be viewed more broadly their derivatives should also considered. In fact, already published results confirm transformation products NSAIDs including DIC may cause a variety potentially negative marine organisms, sometimes showing increased biological activity. To date, however, little known about bioconcentration metabolites role sex this process. Therefore, present study for first time evaluates sex-related differences estimates metabolite, 4-OH DIC, Mytilus trossulus tissues. experiment lasting 7 days, mussels were exposed at concentrations 68.22 20.85 μg/L, respectively. Our confirms can taken up not only native form, but metabolised further. Furthermore, work, mass balance was performed stability both studied compounds under experimental conditions analysed. Obtained suggest stable than derivative tested conditions, further analyses environmental fate these necessary.

Язык: Английский

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Titanium dioxide/cadmium sulfide photoanode applied to photoelectrodegradation of naproxen in wastewater

Journal of Electroanalytical Chemistry, Год журнала: 2021, Номер 897, С. 115571 - 115571

Опубликована: Авг. 3, 2021

Язык: Английский

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