Applications and influencing factors of the biochar-persulfate based advanced oxidation processes for the remediation of groundwater and soil contaminated with organic compounds

The Science of The Total Environment, Год журнала: 2022, Номер 836, С. 155421 - 155421

Опубликована: Апрель 25, 2022

Язык: Английский

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Metformin beyond an anti-diabetic agent: A comprehensive and mechanistic review on its effects against natural and chemical toxins

Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 165, С. 115263 - 115263

Опубликована: Авг. 2, 2023

In addition to the anti-diabetic effect of metformin, a growing number studies have shown that metformin has some exciting properties, such as anti-oxidative capabilities, anticancer, genomic stability, anti-inflammation, and anti-fibrosis, which potent, can treat other disorders than diabetes mellitus. We aimed describe review protective antidotal efficacy against biologicals, chemicals, natural, medications, pesticides, radiation-induced toxicities. A comprehensive search been performed from Scopus, Web Science, PubMed, Google Scholar databases inception March 8, 2023. All in vitro, vivo, clinical were considered. Many suggest affects diseases diabetes. It is radioprotective chemoprotective drug also viral bacterial diseases. be used inflammation-related apoptosis-related abnormalities toxins lower their effects. Besides lowering blood sugar, attenuate effects on body weight, inflammation, apoptosis, necrosis, caspase-3 activation, cell viability survival rate, reactive oxygen species (ROS), NF-κB, TNF-α, many interleukins, lipid profile, enzymes activity catalase superoxide dismutase. reduce histopathological damages induced by kidneys, liver, colon. However, trials human are needed before using therapeutic agent

Язык: Английский

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Homocysteine and diabetes: Role in macrovascular and microvascular complications

Journal of Diabetes and its Complications, Год журнала: 2020, Номер 35(3), С. 107834 - 107834

Опубликована: Дек. 31, 2020

Язык: Английский

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Hydrogen sulfide in ageing, longevity and disease

Biochemical Journal, Год журнала: 2021, Номер 478(19), С. 3485 - 3504

Опубликована: Окт. 6, 2021

Hydrogen sulfide (H2S) modulates many biological processes, including ageing. Initially considered a hazardous toxic gas, it is now recognised that H2S produced endogenously across taxa and key mediator of processes promote longevity improve late-life health. In this review, we consider the developments in our understanding gaseous signalling molecule context health disease, discuss potential mechanisms through which can influence central to ageing highlight emergence novel H2S-based therapeutics. We also major challenges may potentially hinder development such therapies.

Язык: Английский

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Neuroprotective effects of 18β-glycyrrhetinic acid against bisphenol A-induced neurotoxicity in rats: involvement of neuronal apoptosis, endoplasmic reticulum stress and JAK1/STAT1 signaling pathway

Metabolic Brain Disease, Год журнала: 2022, Номер 37(6), С. 1931 - 1940

Опубликована: Июнь 14, 2022

Язык: Английский

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Bisphenol a downregulates GLUT4 expression by activating aryl hydrocarbon receptor to exacerbate polycystic ovary syndrome

Cell Communication and Signaling, Год журнала: 2024, Номер 22(1)

Опубликована: Янв. 10, 2024

Abstract Background Bisphenol A (BPA) levels are high in women with polycystic ovary syndrome (PCOS). The mechanism by which BPA induces abnormal glucose metabolism PCOS patients is largely unknown. Methods Serum and urine samples were collected from without (control) at the reproductive medicine center informed consent. Non-PCOS who received vitro fertilization recruited for collection of ovarian follicular fluid granular cells. Wild-type C57BL/6 AhR −/− mice used to verify effects on PCOS. Real-time PCR, western blotting, ELISA conducted analyze function BPA. Chip-qPCR verified role GLUT4 transcription. Flow cytometry was performed determine uptake. Results positive correlation observed between concentration serum patients. aggravated changes metabolism, impaired fertility, increased body fat. Mechanistically, we showed that activated led decreased transport via downregulation Therefore, use inhibitors or knockout could effectively rescue BPA-induced metabolic disorders mice. Conclusions Our results revealed suppressed expression induced activating AhR, causing insulin resistance, thus a potential contributor development be new therapeutic target

Язык: Английский

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Hepatoprotective effects of oridonin against bisphenol A induced liver injury in rats via inhibiting the activity of xanthione oxidase

The Science of The Total Environment, Год журнала: 2021, Номер 770, С. 145301 - 145301

Опубликована: Янв. 22, 2021

Язык: Английский

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Cineole regulates Wnt/β-catenin pathway through Nrf2/keap1/ROS to inhibit bisphenol A-induced apoptosis, autophagy inhibition and immunosuppression of grass carp hepatocytes

Fish & Shellfish Immunology, Год журнала: 2022, Номер 131, С. 30 - 41

Опубликована: Окт. 1, 2022

Язык: Английский

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Bisphenol A aggravates renal apoptosis and necroptosis in selenium‐deficient chickens via oxidative stress and PI3K/AKT pathway

Journal of Cellular Physiology, Год журнала: 2022, Номер 237(8), С. 3292 - 3304

Опубликована: Май 26, 2022

Abstract Bisphenol A (BPA) in the environment can have deleterious effects on humans and animals. BPA exert nephrotoxicity by inducing oxidative stress. Selenium (Se) deficiency specifically impair kidney tissues additionally show a synergistic effect toxicity of several environmental chemicals. However, toxic chicken whether Se produces remain poorly understood. Herein, we established exposure models model vivo vitro, described discovery path aggravation apoptosis necroptosis Se‐deficient kidneys via regulation stress phosphatidylinositol 3‐kinase/threonine kinase (PI3K/AKT) signaling pathway. We found that increased reactive oxygen species malondialdehyde levels, reduced activities catalase, GPx, superoxide dismutase, downregulated PI3K AKT expressions, activated Bcl/Bax‐Caspase 9‐Caspase 3, receptor‐interacting protein 1/mixed lineage domain‐like pathways, resulting kidney. In addition, significantly promoted expression renal BPA‐exposed kidneys. Altogether, our results showed aggravates PI3K/AKT Our findings elucidate mechanism exacerbation chickens will provide great significance for protection ecological animal health.

Язык: Английский

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Application of In Vitro Models for Studying the Mechanisms Underlying the Obesogenic Action of Endocrine-Disrupting Chemicals (EDCs) as Food Contaminants—A Review

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(2), С. 1083 - 1083

Опубликована: Янв. 5, 2023

Obesogenic endocrine-disrupting chemicals (EDCs) belong to the group of environmental contaminants, which can adversely affect human health. A growing body evidence supports that chronic exposure EDCs contribute a rapid increase in obesity among adults and children, especially wealthy industrialized countries with high production widely used industrial such as plasticizers (bisphenols phthalates), parabens, flame retardants, pesticides. The main source obesogenic is through diet, particularly consumption contaminated food meat, fish, fruit, vegetables, milk, dairy products. promote by stimulating adipo- lipogenesis target cells adipocytes hepatocytes, disrupting glucose metabolism insulin secretion, impacting hormonal appetite/satiety regulation. In vitro models still play an essential role investigating potential obesogens. review aimed provide information on currently available two-dimensional (2D) animal cell applied for studying mechanisms action various contaminants. advantages limitations representing crucial endocrine tissue (adipose tissue) organs (liver pancreas) involved etiology metabolic diseases, are evaluate effects their disruption activity, were thoroughly critically discussed.

Язык: Английский

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