Effect of bisphenol A on the neurological system: a review update

Archives of Toxicology, Год журнала: 2023, Номер 98(1), С. 1 - 73

Опубликована: Окт. 19, 2023

Bisphenol A (BPA) is an endocrine-disrupting chemical (EDC) and one of the most produced synthetic compounds worldwide. BPA can be found in epoxy resins polycarbonate plastics, which are frequently used food storage baby bottles. However, bind mainly to estrogen receptors, interfering with various neurologic functions, its use a topic significant concern. Nonetheless, neurotoxicity has not been fully understood despite numerous investigations on disruptive effects. Therefore, this review aims highlight recent studies implications system. Our findings suggest that exposure impairs structural molecular brain changes, promoting oxidative stress, changing expression levels several crucial genes proteins, destructive effects neurotransmitters, excitotoxicity neuroinflammation, damaged blood-brain barrier function, neuronal damage, apoptosis effects, disruption intracellular Ca

Язык: Английский

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Pharmacological Features of 18β-Glycyrrhetinic Acid: A Pentacyclic Triterpenoid of Therapeutic Potential

Plants, Год журнала: 2023, Номер 12(5), С. 1086 - 1086

Опубликована: Март 1, 2023

Glycyrrhiza glabra L. (belonging to the family Leguminosae), commonly known as Licorice, is a popular medicinal plant that has been used in traditional medicine worldwide for its ethnopharmacological efficacy treating several ailments. Natural herbal substances with strong biological activity have recently received much attention. The main metabolite of glycyrrhizic acid 18β-glycyrrhetinic (18βGA), pentacyclic triterpene. A major active component derived from licorice root, 18βGA sparked lot attention due pharmacological properties. current review thoroughly examines literature on 18βGA, obtained work provides insight into activities and potential mechanisms action involved. contains variety phytoconstituents such which effects including antiasthmatic, hepatoprotective, anticancer, nephroprotective, antidiabetic, antileishmanial, antiviral, antibacterial, antipsoriasis, antiosteoporosis, antiepileptic, antiarrhythmic, anti-inflammatory, also useful management pulmonary arterial hypertension, antipsychotic-induced hyperprolactinemia, cerebral ischemia. This research characteristics throughout recent decades demonstrate therapeutic any gaps may exist, presenting possibilities future drug development.

Язык: Английский

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The protective effects of chrysin on cadmium-induced pulmonary toxicity; a multi-biomarker approach

Environmental Science and Pollution Research, Год журнала: 2023, Номер 30(38), С. 89479 - 89494

Опубликована: Июль 15, 2023

Язык: Английский

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Sinapic acid protects against lead acetate‐induced lung toxicity by reducing oxidative stress, apoptosis, inflammation, and endoplasmic reticulum stress damage

Environmental Toxicology, Год журнала: 2024, Номер 39(7), С. 3820 - 3832

Опубликована: Март 26, 2024

Abstract Lead acetate (PbAc) is a compound that produces toxicity in many tissues after exposure. Sinapic acid (SNP) possesses biological and pharmacological properties. This study aimed to investigate the efficacy of SNP on PbAc lung tissue. was administered orally at 30 mg/kg 5 or 10 for 7 days. Biochemical, genetic, histological methods were used inflammatory, apoptotic, endoplasmic reticulum stress, oxidative stress damage levels administration induced PbAc‐reduced antioxidant (GSH, SOD, CAT, GPx) expression HO‐1 It also reduced MDA, by PbAc, thus alleviated stress. decreased inflammatory markers NF‐κB, TNF‐α IL‐1β tissue exhibited anti‐inflammatory effect. increased apoptotic Bax, Apaf‐1, Caspase‐3 mRNA transcription anti‐apoptotic Bcl‐2 tissues. reversing this situation. On other hand, regulated these brought them closer control group. caused prolonged ER increasing ATF6, PERK, IRE1α, GRP78 activity stopped tended retreat with SNP. After evaluating all data, While toxic tissue, showed protective effect reducing damage.

Язык: Английский

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Protective Effects of Selenium Nanoparticles against Bisphenol A-Induced Toxicity in Porcine Intestinal Epithelial Cells

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(8), С. 7242 - 7242

Опубликована: Апрель 14, 2023

Bisphenol A (BPA) is widely used to harden plastics and polycarbonates causes serious toxic effects in multiple organs, including the intestines. Selenium, as an essential nutrient element for humans animals, exhibits a predominant effect various physiological processes. Selenium nanoparticles have attracted more attention due their outstanding biological activity biosafety. We prepared chitosan-coated selenium (SeNPs) further compared protective effects, investigated underlying mechanism of SeNPs inorganic (Na2SeO3) on BPA-induced toxicity porcine intestinal epithelial cells (IPEC-J2). The particle size, zeta potential, microstructure were detected by using nano-selenium size meter transmission electron microscope. IPEC-J2 exposed BPA alone or simultaneously Na2SeO3. CCK8 assay was performed screen optimal concentration exposure Na2SeO3 treatment. apoptosis rate flow cytometry. Real-time PCR Western blot methods analyze mRNA protein expression factors related tight junctions, apoptosis, inflammatory responses endoplasmic reticulum stress. Increased death morphological damage observed after exposure, these increases attenuated disturbed junction function involved with decreased Zonula occludens 1 (ZO-1), occludin, claudin-1 proteins. Proinflammatory response mediated transcription factor nuclear factor-k-gene binding (NF-κB), such elevated levels interleukin-1β(IL-1β), interleukin-6 (IL-6), interferon-γ (IFN-γ), interleukin-17 (IL-17), tumor necrosis factor-α (TNF-α) induced at 6 24 h exposure. also oxidant/antioxidant status led oxidative cell indicated increased BCL-2-associated X (Bax), caspase 3, 8, 9 B-cell lymphoma-2 (Bcl-2) Bcl-xl expression. activated stress (ERS) receptor kinase receptor-like (PERK), Inositol requiring enzyme (IRE1α), activating (ATF6). found that treatment can alleviate caused BPA. superior counteracted injury, proinflammatory response, stress, ERS Our findings suggest protect from damage, partly through inhibiting ER activation subsequently attenuating suppressing thus enhancing barrier function. data indicate may represent effective reliable tool preventing animals humans.

Язык: Английский

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18β‐Glycyrrhetinic acid exerts cardioprotective effects against BPA‐induced cardiotoxicity through antiapoptotic and antioxidant mechanisms

Journal of Biochemical and Molecular Toxicology, Год журнала: 2024, Номер 38(2)

Опубликована: Янв. 24, 2024

Abstract Bisphenol A (BPA) is a synthetic environmental pollutant widely used in industry, as well an endocrine disrupting chemicals and has toxic effects on heart tissue. The aim of this study to reveal the cardioprotective 18β‐glycyrretinic acid (GA) against BPA‐induced cardiotoxicity rats. In study, 40 male rats were five different groups (each group includes eight rats) formed. applied BPA (250 mg/kg b.w.) alone or with GA (50 100 for 14 days. Rats killed Day 15 tissues taken analysis. treatment decreased serum lactate dehydrogenase creatine kinase MB levels, reducing damage. showed ameliorative lipid peroxidation oxidative stress caused by increasing antioxidant enzyme activities (glutathione peroxidase, superoxide dismutase, catalase) GSH level tissue decreasing MDA level. addition, antiapoptotic effect Bcl‐2, procaspase‐3, ‐9 protein expression levels Bax, cytochrome c, P53 As result, it was found that exhibiting damage BPA, pollutant. Thus, supported could be potential agent.

Язык: Английский

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Protective Effects of Syringic Acid Against Oxidative Damage, Apoptosis, Autophagy, Inflammation, Testicular Histopathologic Disorders, and Impaired Sperm Quality in the Testicular Tissue of Rats Induced by Mercuric Chloride

Environmental Toxicology, Год журнала: 2024, Номер 39(10), С. 4803 - 4814

Опубликована: Авг. 3, 2024

Mercury (Hg) is one of the most toxic heavy metals that damage testicular tissue. chloride (HgCl

Язык: Английский

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Health risks of Bisphenol-A exposure: From Wnt signaling perspective

Environmental Research, Год журнала: 2024, Номер 251, С. 118752 - 118752

Опубликована: Март 20, 2024

Язык: Английский

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Mechanism of evodiamine blocking Nrf2/MAPK pathway to inhibit apoptosis of grass carp hepatocytes induced by DEHP

Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology, Год журнала: 2022, Номер 263, С. 109506 - 109506

Опубликована: Ноя. 8, 2022

Язык: Английский

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Antioxidant, Antiinflammatory, and Antiapoptotic Effects of Rutin in Spleen Toxicity Induced by Sodium Valproate in Rats

Türk doğa ve fen dergisi :/Türk doğa ve fen dergisi, Год журнала: 2023, Номер 12(2), С. 138 - 144

Опубликована: Июнь 21, 2023

Aim: Long-term exposure to sodium valproate, an antiepileptic drug, causes toxic effects in tissues, especially by increasing oxidative stress and inflammation. Rutin is a flavanoid with antioxidant, anti-inflammatory antiapoptotic found naturally many plants. In this study, we aimed investigate the of rutin, natural on valproate-induced spleen tissue damage. Materials Methods: 35 male rats were divided into 5 groups as control, valproate+Rutin 50 100 groups. For 14 days, 500 mg/kg dose valproate or rutin administered oral gavage. On day 15, tissues removed biochemical methods, stress, inflammation apoptotic parameters analyzed histologic analysis was performed. Results: The levels apoptosis increased compared control group (p

Язык: Английский

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