Biguanides Associate with Decreased Early Mortality and Risk of Acute Kidney Injury In Hospitalized COVID-19 Patients: a nationwide retrospective cohort study in Japan DOI

Mari Sugimoto,

Hiroaki Kikuchi, Eisei Sohara

и другие.

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Июль 21, 2024

Abstract Background Biguanide (BG) is the most-prescribed oral glucose-lowering medication worldwide and has potential for further therapeutic applications. The Coronavirus disease 2019 (COVID-19) pandemic a global public health emergency. Nevertheless, there are still no established low-cost treatments against COVID-19, of which morbidity mortality rates varing from country to country. Therefore, nationwide study COVID-19 affected population essential explore effect BG COVID-19. Methods From inpatient databases in Japan, covering period September 2021 March 2023, encompasses era following development vaccines, we extracted data 168,370 patients aged 20 under 80 years who were suffered diabetes mellitus treated with antidiabetic agents. primary outcome was 100-day in-hospital mortality, secondary incidence acute kidney injury (AKI) during hospitalization. We compared outcomes received those did not, using logistic regression analysis Cox proportional hazards both propensity score-unmatched matched cohorts. Results death significantly lower group (1.18 %) non-BG (2.41%) (p < 0.001). Similarly, AKI hospitalization (0.66 (1.12%) Kaplan-Meier propensity-score cohort showed better survival rate (adjusted HR, 0.580; 95% CI 0.510-0.658; p Conclusion In patients, use biguanide may be associated reduced risk AKI.

Язык: Английский

Advanced applications of smart electrospun nanofibers in cancer therapy: With insight into material capabilities and electrospinning parameters DOI Creative Commons

Vahid Tayebi-Khorrami,

Pouria Rahmanian‐Devin, Mohammad Reza Fadaei

и другие.

International Journal of Pharmaceutics X, Год журнала: 2024, Номер 8, С. 100265 - 100265

Опубликована: Июнь 26, 2024

Cancer remains a major global health challenge, and despite available treatments, its prognosis poor. Recently, researchers have turned their attention to intelligent nanofibers for cancer drug delivery. These exhibit remarkable capabilities in targeted controlled release. Their inherent characteristics, such as high surface area-to-volume ratio, make them attractive candidates delivery applications. Smart can release drugs response specific stimuli, including pH, temperature, magnetic fields, light. This unique feature not only reduces side effects but also enhances the overall efficiency of systems. Electrospinning, widely used method, allows precision fabrication smart nanofibers. Its advantages include efficiency, user-friendliness, ability control various manufacturing parameters. In this review, we explore latest developments producing electrospun treatment. Additionally, discuss materials these critical parameters involved electrospinning process.

Язык: Английский

Процитировано

20
How caffeic acid and its derivatives combat diabetes and its complications: A systematic review DOI Creative Commons
Iman Akhlaghipour, Arya Nasimi Shad, Vahid Reza Askari

и другие.

Journal of Functional Foods, Год журнала: 2023, Номер 110, С. 105862 - 105862

Опубликована: Окт. 21, 2023

Caffeic acid (CA) and its derivatives, caffeic phenyl ethyl amide (CAPA) ester (CAPE), were shown to have anti-oxidant, anti-inflammatory, anti-diabetic effects. Therefore, in this systematic review, a literature search was conducted from inception until June 2023 on major electronic databases (ISI Web of Science, MEDLINE/PubMed, Scopus, Cochrane Library, Google Scholar) find studies evaluating the impacts CA common derivatives diabetes complications different cellular, animal, clinical studies. therapy mitigated levels blood glucose, oxidative stress markers, inflammatory cytokines while increasing anti-oxidative markers cellular animal models diabetes. Furthermore, they remarkably propagated insulin secretion ameliorated resistance. also revealed protective effects against complications, such as diabetic-induced hepatic damage, cardiomyopathy, endothelial dysfunction, retinopathy, cognitive deficit, nephropathy, neuropathy.

Язык: Английский

Процитировано

22
Pharmacodynamic, pharmacokinetic, toxicity, and recent advances in Eugenol's potential benefits against natural and chemical noxious agents: A mechanistic review DOI

Negin Tavvabi-Kashani,

Maede Hasanpour, Vafa Baradaran Rahimi

и другие.

Toxicon, Год журнала: 2024, Номер 238, С. 107607 - 107607

Опубликована: Янв. 7, 2024

Язык: Английский

Процитировано

9
Metabolic signatures in post-myocardial infarction heart failure, including insights into prediction, intervention, and prognosis DOI Open Access

Xueyan Peng,

Jie Du, Yuan Wang

и другие.

Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 170, С. 116079 - 116079

Опубликована: Дек. 26, 2023

Heart failure (HF) is a prevalent long-term complication of myocardial infarction (MI). The incidence post-MI HF high, and patients with the condition have poor prognosis. Accurate identification individuals at high risk for crucial implementation protective ideally personalized strategy to prevent fatal events. Post-MI characterized by adverse cardiac remodeling, which results from metabolic changes in response ischemia. Moreover, various factors, including genetics, diet, obesity, can influence pathways patients. This review focuses on signatures that could serve as non-invasive biomarkers early high-risk populations. We also explore how metabolism participates pathophysiology HF. Furthermore, we discuss potential metabolites novel targets treatment prognostic evaluation. It expected provide valuable suggestions clinical prevention perspective.

Язык: Английский

Процитировано

11
Stem cell and exosome therapies for regenerating damaged myocardium in heart failure DOI
Roghayeh Yahyazadeh, Vafa Baradaran Rahimi, Vahid Reza Askari

и другие.

Life Sciences, Год журнала: 2024, Номер 351, С. 122858 - 122858

Опубликована: Июнь 22, 2024

Язык: Английский

Процитировано

4
An effective treatment approach of liposomally encapsulated metformin in colon cancer DOI
Enis A. Cetin, Olcay Boyacıoğlu, Seda Örenay-Boyacıoğlu

и другие.

Medical Oncology, Год журнала: 2024, Номер 41(4)

Опубликована: Фев. 28, 2024

Язык: Английский

Процитировано

3
Investigating the Antioxidant Activity of Metformin HCl: Theoretical Intuitions and Experimental Evidences DOI Creative Commons

K.P. Safna Hussan,

Anna Kurian,

Mohamed Shahin Thayyil

и другие.

Next research., Год журнала: 2025, Номер unknown, С. 100166 - 100166

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Efficacy of Traditional Chinese Medicine combined with Conventional Western Medicine on Metabolic Syndrome: A Bayesian Network Meta-Analysis DOI
Yanmin Zhang, Yixuan Fang, Nannan Xing

и другие.

Journal of Herbal Medicine, Год журнала: 2025, Номер unknown, С. 100998 - 100998

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0
Protective Effects of Flavonoids in Diabetic Cardiomyopathy: A Comprehensive Review on the Mechanistic Insights DOI
Sonia Ramos

Molecular Nutrition & Food Research, Год журнала: 2025, Номер unknown

Опубликована: Март 31, 2025

ABSTRACT Diabetic cardiomyopathy (DCM) is one of the leading causes mortality among diabetic patients. Flavonoid are most abundant group phytochemicals in fruits and vegetables, have received increasing interest as potential chemopreventive antidiabetic agents. Flavonoids might contribute to prevent or delay DCM by regulating cardiac metabolism, insulin signaling, oxidative stress, apoptosis, autophagy, inflammation. Among other effects, flavonoids been proved enhance glucose uptake, decrease cellular lipid accumulation, suppress stress. However, mechanistic basis these effects not fully understood, many points remain be clarified. This review provides insight into molecular mechanisms flavonoid activity summarizing cell culture animal model studies.

Язык: Английский

Процитировано

0
Metformin attenuates colitis via blocking STAT3 acetylation by reducing acetyl-CoA production DOI Creative Commons
Xiangyun Li, Zixuan Xiang, Xiaoli Wang

и другие.

Journal of Advanced Research, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

While metformin has been shown to alleviate dextran sulfate sodium (DSS)-induced colitis in murine models, the mechanisms underlying its anti-inflammatory and barrier-restorative effects remain poorly defined. This study investigates role of acetyl coenzyme A (acetyl-CoA)-dependent STAT3 acetylation mediating metformin's therapeutic actions, with goal identifying novel molecular targets for ulcerative (UC) treatment. Acute was induced wild-type C57BL/6J mice via oral DSS administration, followed by daily intraperitoneal Intestinal inflammation, barrier integrity, signaling were assessed using histopathology, western blotting, transmission electron microscopy. To validate STAT3's critical pathogenesis, intestinal epithelium-specific knockout employed, enabling targeted investigation regulation metformin. Metformin attenuated DSS-induced suppressing pro-inflammatory cytokines (TNF-α, IL-6, IL-1β), reducing epithelial apoptosis, restoring tight junction proteins (ZO-1, E-cadherin, Occludin). Mechanistically, reduced acetyl-CoA levels, thereby inhibiting downstream pathway activation. The pivotal progression confirmed mice, as significantly diminished absence STAT3-mediated inflammatory signaling. identifies acetyl-CoA-dependent a mechanism through which ameliorates inflammation dysfunction. These findings not only advance our understanding immunomodulatory properties but also highlight potential targeting metabolism UC.

Язык: Английский

Процитировано

0