Advanced application of nanotechnology in active constituents of Traditional Chinese Medicines

Journal of Nanobiotechnology, Год журнала: 2023, Номер 21(1)

Опубликована: Ноя. 29, 2023

Abstract Traditional Chinese Medicines (TCMs) have been used for centuries the treatment and management of various diseases. However, their effective delivery to targeted sites may be a major challenge due poor water solubility, low bioavailability, potential toxicity. Nanocarriers, such as liposomes, polymeric nanoparticles, inorganic nanoparticles organic/inorganic nanohybrids based on active constituents from TCMs extensively studied promising strategy improve achieve higher therapeutic effect with fewer side effects compared conventional formulations. This review summarizes recent advances in nanocarrier-based systems types TCMs, including terpenoids, polyphenols, alkaloids, flavonoids, quinones, different natural sources. covers design preparation nanocarriers, characterization, vitro/vivo evaluations. Additionally, this highlights challenges opportunities field suggests future directions research. Nanocarrier-based shown great improving efficacy serve comprehensive resource researchers field. Graphical abstract

Язык: Английский

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The Role of Cyclodextrins in COVID-19 Therapy—A Literature Review

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(3), С. 2974 - 2974

Опубликована: Фев. 3, 2023

Coronavirus disease-19 (COVID-19) emerged in December 2019 and quickly spread, giving rise to a pandemic crisis. Therefore, it triggered tireless efforts identify the mechanisms of disease, how prevent treat it, limit hamper its global dissemination. Considering above, search for prophylactic approaches has led revolution reglementary pharmaceutical pipeline, with approval vaccines against COVID-19 an unprecedented way. Moreover, drug repurposing scheme using regulatory-approved antiretroviral agents is also being pursued. However, their physicochemical characteristics or reported adverse events have sometimes limited use. Hence, nanotechnology been employed potentially overcome some these challenges, particularly cyclodextrins. Cyclodextrins are cyclic oligosaccharides that present hydrophobic cavities suitable complexing several drugs. This review, besides presenting studies on inclusion antiviral drugs cyclodextrins, aims summarize currently available therapeutic schemes COVID-19, highlighting those already make use cyclodextrins complexation. In addition, new underscored, potential application increase promising will be addressed. review describes instances which promotes increased bioavailability, action, solubility under analysis. The as active ingredient covered. Finally, toxicity regulatory issues well future perspectives regarding therapy provided.

Язык: Английский

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Dietary Phenolic Compounds—Wellbeing and Perspective Applications

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(9), С. 4769 - 4769

Опубликована: Апрель 27, 2024

Contemporary living is continuously leading to poor everyday choices resulting in the manifestation of various diseases. The benefits plant-based nutrition are undeniable and research on topic rising. Modern man now aware possibilities that plant can provide seeking ways benefit from it. Dietary phenolic compounds among easily accessible beneficial substances exhibit antioxidant, anti-inflammatory, antitumor, antibacterial, antiviral, antifungal, antiparasitic, analgesic, anti-diabetic, anti-atherogenic, antiproliferative, as well cardio-and neuroprotective activities. Several industries exploring incorporate biologically active their produce. This review concentrated presenting current information about dietary contribution maintaining good health. Additionally, this content will demonstrate importance prosperity natural for fields, i.e., food industry, cosmetology, biotechnology, others.

Язык: Английский

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Exploring the Correlation Between the Molecular Structure and Biological Activities of Metal–Phenolic Compound Complexes: Research and Description of the Role of Metal Ions in Improving the Antioxidant Activities of Phenolic Compounds

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(21), С. 11775 - 11775

Опубликована: Ноя. 1, 2024

We discussed and summarized the latest data from global literature on action of polyphenolic antioxidants their metal complexes. The review also includes a summary outcomes theoretical computations our many years experimental experience. employed various methods, including spectroscopy (FT-IR, FT-Raman, NMR, UV/Vis), X-ray diffraction, thermal analysis, quantum calculations, biological assays (DPPH, ABTS, FRAP, cytotoxicity, genotoxicity tests). According to research, number position hydroxyl groups in aromatic rings, as well delocalization electron charge conjugated double bonds, have major impact antioxidant effectiveness studied compounds. Another important factor is complexation, whereby high ionic potential metals (e.g., Fe(III), Cr(III), Cu(II)) enhance properties by stabilizing charge, while low Ag(I), Hg(II), Pb(II)) reduce efficacy disrupting distribution. However, we observed no simple correlation between capacity. This paper gives insights that will aid identifying new, effective antioxidants, which are vital for nutrition prevention neurodegenerative illnesses. Our results outline connections activity molecular structure, offering foundation methodical design antioxidants. shows detail how use complementary methods assess electronic systems ligands. approach moves beyond traditional "trial error" method, allowing more efficient rational development future

Язык: Английский

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Food wastes phenolic compounds (PCs): overview of contemporary greener extraction technologies, industrial potential, and its integration into circular bioeconomy

Energy Ecology and Environment, Год журнала: 2024, Номер 9(5), С. 455 - 485

Опубликована: Апрель 6, 2024

Язык: Английский

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Pyrogallol protects against influenza A virus‐triggered lethal lung injury by activating the Nrf2–PPAR‐γ–HO‐1 signaling axis

MedComm, Год журнала: 2024, Номер 5(4)

Опубликована: Апрель 1, 2024

Abstract Pyrogallol, a natural polyphenol compound (1,2,3‐trihydroxybenzene), has shown efficacy in the therapeutic treatment of disorders associated with inflammation. Nevertheless, mechanisms underlying protective properties pyrogallol against influenza A virus infection are not yet established. We established this study that effectively alleviated H1N1 virus‐induced lung injury and reduced mortality. Treatment was found to promote expression nuclear translocation factor erythroid‐2‐related 2 (Nrf2) peroxisome proliferator‐activated receptor gamma (PPAR‐γ). Notably, activation Nrf2 by involved elevating PPAR‐γ, both which act synergistically enhance heme oxygenase‐1 (HO‐1) synthesis. Blocking HO‐1 zinc protoporphyrin (ZnPP) suppressive impact on virus‐mediated aberrant retinoic acid‐inducible gene‐I‐nuclear kappa B (RIG‐I–NF‐κB) signaling, thus abolished dampening effects excessive proinflammatory mediators cell death (including apoptosis, necrosis, ferroptosis). Furthermore, HO‐1‐independent inactivation janus kinase 1/signal transducers activators transcription (JAK1/STATs) HO‐1‐dependent RIG‐I‐augmented STAT1/2 were abrogated pyrogallol, resulting suppression enhanced transcriptional activity interferon‐stimulated gene 3 (ISGF3) complexes, prominently inhibiting amplification reaction apoptosis interferon‐beta (IFN‐β)‐sensitized cells. The provides evidence alleviates responses abnormal via induction, suggesting it could be potential agent for treating influenza.

Язык: Английский

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Tannins as Antimicrobial Agents: Understanding Toxic Effects on Pathogens

Toxicon, Год журнала: 2024, Номер 247, С. 107812 - 107812

Опубликована: Июнь 20, 2024

Язык: Английский

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Polyphenols as antiviral agents: Assessing their potential usage and benefits in aquaculture

Aquaculture International, Год журнала: 2025, Номер 33(2)

Опубликована: Янв. 2, 2025

Язык: Английский

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In Vitro Determination of Antimicrobial, Antioxidant and Antiviral Properties of Greek Plant Extracts

Microorganisms, Год журнала: 2025, Номер 13(1), С. 177 - 177

Опубликована: Янв. 16, 2025

The medicinal potential of plant extracts, especially their antimicrobial, antioxidant, antiviral and cytotoxic properties, has gained significant attention in recent years. This study examined the vitro bioactivities several selected Greek plants, like Eucalyptus globulus L., Thymus vulgaris Salvia rosmarinus L. Ocimum basilicum are well-known for traditional therapeutic use. Minimum inhibitory concentration (MIC) assays were used to evaluate antimicrobial activity extracts against pathogenic bacteria. antioxidant was carried out using DPPH method, while cytotoxicity plants determined Alamar Blue method. In addition, efficacy samples tested DENV different cell lines. majority herbs demonstrated action (MIC = 30–3000 μg∙mL−1). showed great activity, extract turned be most effective (IC50 12.89 ± 0.11 contrast, had lowest 71.02 0.42 results method presented with CC50 values, it shown that exhibited highest (CC50 5.94% v/v 0.04). Similarly, expressed as EC50 characterized sample dengue virus infection, values estimated at 2.37% 0.6 (HuhD-2 cells infected DENV-2) 0.36% 0.004 (Huh7.5 DVR2A). These findings provide a foundation further studies order combat infectious diseases promote human health.

Язык: Английский

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Superheated steam processing: An emerging technology to improve food quality and safety

Critical Reviews in Food Science and Nutrition, Год журнала: 2022, Номер 63(27), С. 8720 - 8736

Опубликована: Апрель 7, 2022

Heat processing is one of the most efficient strategies used in food industry to improve quality and prolong shelf life. However, conventional methods such as microwave heating, burning charcoal treatment, boiling, frying are energy-inefficient often lead inferior product quality. Superheated steam (SHS) an innovative technology that offers many potential benefits increasingly industry. Compared methods, SHS holds higher heat transfer coefficients, which can reduce microorganisms on surface foodstuffs efficiently. Additionally, generates a low oxygen environment, prevents lipid oxidation harmful compounds generation. Furthermore, facilitate development desired quality, protein denaturation with functional characteristics, proper starch gelatinization, also nutrient loss, physicochemical properties foodstuffs. The current work provides comprehensive review impact nutritional, physicochemical, safety various including meat, fruits, vegetables, cereals, etc. it manufacturers researchers basic knowledge practical techniques for foodstuffs, may scope systems healthy sustainable one.

Язык: Английский

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