Toxics,
Год журнала:
2023,
Номер
11(9), С. 730 - 730
Опубликована: Авг. 25, 2023
Microplastic
pollution
poses
a
threat
to
human
health.
It
is
possible
that
the
increase
in
incidence
of
inflammatory
bowel
disease
associated
with
exposure
microplastics.
We
investigated
effect
consumption
polystyrene
microparticles
diameter
5
μm
at
dose
2.3
mg/kg/day
for
6
weeks
on
morphological
changes
colons
healthy
male
C57BL/6
mice
and
acute
colitis
induced
by
1%
dextran
sulfate
sodium
solution
(DSS).
In
mice,
microplastics
caused
an
number
endocrine
cells,
content
highly
sulfated
mucins
goblet
cells
lamina
propria,
decrease
volume
fraction
macrophages.
more
severe
colitis,
which
characterized
greater
prevalence
ulcers
inflammation
neutral
cells.
Environmental Science & Technology,
Год журнала:
2024,
Номер
58(4), С. 1832 - 1841
Опубликована: Янв. 17, 2024
The
massive
production
of
plastics
causes
the
ubiquitous
existence
microplastics
(MPs)
in
biota,
therefore,
posing
exposure
risks
and
potential
health
concerns
to
human
beings.
However,
exact
mechanisms
MPs-induced
toxicities
abnormalities
are
largely
unknown.
In
this
study,
we
developed
a
mouse
model
gavage
polystyrene
(PS
MPs)
for
30
days.
We
found
that
PS
MPs
can
damage
intestinal
barrier,
accumulate
liver
tissue,
cause
injury.
intestine
both
highly
associated
with
bile
acid
(BA)
metabolism.
Indeed,
dysregulate
BA
synthesis
efflux-related
gene
expression
liver,
causing
cholestasis.
Tandemly,
alter
ratio
primary
secondary
feces
by
affecting
composition
flora.
At
last,
mice's
fecal
profile,
which
affects
normal
Taken
together,
present
study
provides
robust
data
on
mechanism
toxicity
disturbance
metabolism
via
4-step
gut-liver
loop.
