Effects of microplastics, pesticides and nano-materials on fish health, oxidative stress and antioxidant defense mechanism

Frontiers in Physiology, Год журнала: 2023, Номер 14

Опубликована: Июнь 26, 2023

Microplastics and pesticides are emerging contaminants in the marine biota, which cause many harmful effects on aquatic organisms, especially fish. Fish is a staple affordable food source, rich animal protein, along with various vitamins, essential amino acids, minerals. Exposure of fish to microplastics, pesticides, nanoparticles generates ROS induces oxidative stress, inflammation, immunotoxicity, genotoxicity, DNA damage alters gut microbiota, thus reducing growth quality Changes behavioral patterns, swimming, feeding habits were also observed under exposures above contaminants. These affect Nrf-2, JNK, ERK, NF-κB, MAPK signaling pathways. And Nrf2-KEAP1 signalling modulates redox status marinating enzymes Effects found modulate antioxidant enzymes, including superoxide dismutase, catalase, glutathione system. So, protect health from contribution nano-technology or nano-formulations was researched. A decrease nutritional population significantly impacts human diet, influencing traditions economics worldwide. On other hand, traces microplastics habitat water can enter humans by consuming contaminated may result serious hazards. This review summarizes stress caused due nano-particle contamination exposure their impact health. As rescue mechanism, use management disease discussed.

Язык: Английский

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Microplastics in the human body: A comprehensive review of exposure, distribution, migration mechanisms, and toxicity

The Science of The Total Environment, Год журнала: 2024, Номер 946, С. 174215 - 174215

Опубликована: Июнь 22, 2024

Язык: Английский

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Hazards of microplastics exposure to liver function in fishes: A systematic review and meta-analysis

Marine Environmental Research, Год журнала: 2024, Номер 196, С. 106423 - 106423

Опубликована: Фев. 27, 2024

Язык: Английский

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Microplastics as vectors of other contaminants: Analytical determination techniques and remediation methods

The Science of The Total Environment, Год журнала: 2023, Номер 908, С. 168244 - 168244

Опубликована: Ноя. 3, 2023

Язык: Английский

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Effect of emerging pollutants on the gut microbiota of freshwater animals: Focusing on microplastics and pesticides

The Science of The Total Environment, Год журнала: 2024, Номер 948, С. 174809 - 174809

Опубликована: Июль 15, 2024

Язык: Английский

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Immunotoxicity of microplastics in fish

Fish & Shellfish Immunology, Год журнала: 2024, Номер 150, С. 109619 - 109619

Опубликована: Май 10, 2024

Язык: Английский

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Meta-analysis of the Effects of Microplastic on Fish: Insights into Growth, Survival, Reproduction, Oxidative Stress, and Gut Microbiota Diversity

Water Research, Год журнала: 2024, Номер 267, С. 122493 - 122493

Опубликована: Сен. 21, 2024

Язык: Английский

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Impact of microplastics and nanoplastics on fish health and reproduction

Aquaculture, Год журнала: 2024, Номер 590, С. 741037 - 741037

Опубликована: Май 3, 2024

Язык: Английский

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Microcystin-LR and polystyrene microplastics jointly lead to hepatic histopathological damage and antioxidant dysfunction in male zebrafish

Environmental Pollution, Год журнала: 2024, Номер 347, С. 123789 - 123789

Опубликована: Март 13, 2024

Язык: Английский

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Subchronic oral exposure to polystyrene microplastics affects hepatic lipid metabolism, inflammation, and oxidative balance in gilthead seabream (Sparus aurata)

Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 279, С. 116455 - 116455

Опубликована: Май 20, 2024

Microplastics (MPs) pose a clear threat to aquatic organisms affecting their health. Their impact on liver homeostasis, as well the potential onset of nonalcoholic fatty disease (NAFLD), is still poorly investigated and remains almost unknown. The aim this study was evaluate outcomes subchronic exposure polystyrene MPs (PS-MPs; 1–20 μm; 0, 25, or 250 mg/kg b.w./day) lipid metabolism, inflammation, oxidative balance in gilthead seabreams (Sparus aurata Linnaeus, 1758) exposed for 21 days via contaminated food. PS-MPs induced an up-regulation mRNA levels crucial genes associated with synthesis storage (i.e., PPARy, Srebp1, Fasn) without modifications involved catabolism PPARα, HL, Pla2) transport metabolism (Fabp1) liver. increase CSF1R pro-inflammatory cytokines gene expression TNF-α IL-1β) also observed fish dose-dependent manner. These findings were confirmed by hepatic histological evaluations reporting evidence accumulation, necrosis. Moreover, caused impairment antioxidant defense system through alteration its enzymatic (catalase, superoxide dismutase, glutathione reductase) non-enzymatic (glutathione) components, resulting increased production reactive oxygen species (ROS) malondialdehyde (MDA), biomarkers damage. detoxifying enzymes inferred decreased Ethoxyresorufin-O-deethylase (EROD) activity glutathione-S-transferase (GST) at highest PS-MP dose. suggests that affect health seabream. dysfunction damage result from detrimental interplay damage, systems modifications, altering gut-liver axis homeostasis. This scenario suggestive involvement MP-induced effects progression

Язык: Английский

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