Resveratrol Alleviated T‐2 Toxin‐Induced Liver Injury via Preservation of Nrf2 Pathway and GSH Synthesis

Environmental Toxicology, Год журнала: 2024, Номер unknown

Опубликована: Сен. 3, 2024

ABSTRACT T‐2 toxin is a trichothecene mycotoxin and considered as an extremely inevitable pollutant with potent hepatotoxicity. However, the approach to alleviation of toxin‐triggered hepatotoxicity has been recognized serious challenge. Resveratrol (Res) polyphenol natural product isolated from various plant species, but its protective effect against detailed mechanism remains obscure. In present study, Res was evaluated, underlying mechanisms were further revealed in mice. Functionally, inhibited liver injury, oxidative damage, mitochondrial dysfunction induced by toxin. Mechanistically, modulated Nrf2‐mediated antioxidant pathway glutathione synthesis inhibition. Collectively, our findings first showed beyond doubt that ameliorated injury regulating Nrf2 pathways

Язык: Английский

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Qi-Shen-Tang alleviates retinitis pigmentosa by inhibiting ferroptotic features via the NRF2/GPX4 signaling pathway

Heliyon, Год журнала: 2023, Номер 9(11), С. e22443 - e22443

Опубликована: Ноя. 1, 2023

Ferroptosis has been observed during retinal photoreceptor cell death, suggesting that it plays a role in retinitis pigmentosa (RP) pathogenesis. Qi-Shen-Tang (QST) is combination of two traditional Chinese medicines used for the treatment ophthalmic diseases; however, its mechanism action RP and ferroptosis remains unclear. Therefore, this study aimed to explore effect potential molecular mechanisms QST on RP. significantly improved tissue morphology function retina model mice. A significant increase blood flow normalization fundus structure were mice group. After treatment, level iron production malondialdehyde decreased significantly; levels superoxide dismutase glutathione increased protein expression peroxidase 4 (GPX4), synthetase, solute carrier family 7 member 11, nuclear factor erythroid 2-related 2 (NRF2) significantly. The docking results demonstrated interactions between small molecules key proteins NRF2/GPX4 signaling pathway. Our indicate may inhibit by inhibiting pathway, thereby reducing RP-induced damage tissue.

Язык: Английский

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Recent advances in potential therapeutic targets of ferroptosis‑associated pathways for the treatment of stroke (Review)

Molecular Medicine Reports, Год журнала: 2024, Номер 30(1)

Опубликована: Май 22, 2024

Stroke is a severe neurological disease that associated with high rates of morbidity and mortality, the underlying pathological processes are complex. Ferroptosis fulfills significant role in progression treatment stroke. It well established ferroptosis type programmed cell death distinct from other forms or types death. The process involves multiple signaling pathways regulatory mechanisms interact inherent to stroke development. Inducers inhibitors have been shown exert onset this process. Furthermore, it has interfering affects occurrence stroke, indicating targeting may offer promising therapeutic approach for treating patients Hence, present review aimed summarize latest progress made terms using interventions as targets cases provides an overview relevant molecular investigated recent years, highlighting roles inducers Additionally, intervention potential various Traditional Chinese Medicine also summarized. In conclusion, comprehensive afforded by ferroptosis‑associated offering new insights into how be exploited

Язык: Английский

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Isobicyclogermacrenal ameliorates hippocampal ferroptosis involvement in neurochemical disruptions and neuroinflammation induced by sleep deprivation in rats

Phytomedicine, Год журнала: 2024, Номер 136, С. 156306 - 156306

Опубликована: Ноя. 29, 2024

Язык: Английский

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Novel Mechanisms of Perioperative Neurocognitive Disorders: Ferroptosis and Pyroptosis

Neurochemical Research, Год журнала: 2023, Номер 48(10), С. 2969 - 2982

Опубликована: Июнь 8, 2023

Язык: Английский

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