Recent progress of microplastic toxicity on human exposure base on in vitro and in vivo studies

The Science of The Total Environment, Год журнала: 2023, Номер 903, С. 166766 - 166766

Опубликована: Сен. 2, 2023

Язык: Английский

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Micro- and nano-plastics in the atmosphere: A review of occurrence, properties and human health risks

Journal of Hazardous Materials, Год журнала: 2024, Номер 465, С. 133412 - 133412

Опубликована: Янв. 9, 2024

Язык: Английский

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Micro(nano)plastics in the Human Body: Sources, Occurrences, Fates, and Health Risks

Environmental Science & Technology, Год журнала: 2024, Номер unknown

Опубликована: Фев. 5, 2024

The increasing global attention on micro(nano)plastics (MNPs) is a result of their ubiquity in the water, air, soil, and biosphere, exposing humans to MNPs daily basis threatening human health. However, crucial data body, including sources, occurrences, behaviors, health risks, are limited, which greatly impedes any systematic assessment impact body. To further understand effects we must identify existing knowledge gaps that need be immediately addressed provide potential solutions these issues. Herein, examined current literature behaviors body as well risks. Furthermore, identified key resolved comprehensively assess Additionally, complexity lack efficient analytical methods main barriers impeding investigations necessitating development standard unified method. Finally, highlighted for interdisciplinary studies from environmental, biological, medical, chemical, computer, material scientists fill drive research. Considering inevitability occurrence exposure MNPs, more urgently required enhance our understanding negative

Язык: Английский

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Tracing microplastics in rural drinking water in Chongqing, China: Their presence and pathways from source to tap

Journal of Hazardous Materials, Год журнала: 2023, Номер 459, С. 132206 - 132206

Опубликована: Авг. 2, 2023

Язык: Английский

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Influence of the geographic location and house characteristics on the concentration of microplastics in indoor dust

The Science of The Total Environment, Год журнала: 2024, Номер 917, С. 170353 - 170353

Опубликована: Фев. 1, 2024

Язык: Английский

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Microplastics in indoor air from Birmingham, UK: Implications for inhalation exposure

Environmental Pollution, Год журнала: 2024, Номер 362, С. 124960 - 124960

Опубликована: Сен. 24, 2024

Microplastics (MPs) are a group of emerging contaminants that attracted increasing scientific and societal attention over the past decade. So far, most studies on MPs focus characterizing their occurrence, fate, impact in aquatic environment. In contrast, very little is known about magnitude, patterns, associated risks human exposure to MPs, particularly indoors, despite people spending time indoors. This paper provides first study hitherto indoor air via both active passive sampling from 30 homes workplaces Birmingham, UK. The average concentration samples was 15.6 ± 5.4 MP/m

Язык: Английский

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Single pulmonary nanopolystyrene exposure in late-stage pregnancy dysregulates maternal and fetal cardiovascular function

Toxicological Sciences, Год журнала: 2024, Номер 199(1), С. 149 - 159

Опубликована: Фев. 17, 2024

Abstract Large-scale production and waste of plastic materials have resulted in widespread environmental contamination by the breakdown product bulk to micro- nanoplastics (MNPs). The small size these particles enables their suspension air, making pulmonary exposure inevitable. Previous work has demonstrated that xenobiotic nanoparticles during gestation leads maternal vascular impairments, as well cardiovascular dysfunction within fetus. Few studies assessed toxicological consequences nanoplastic (NP) exposure; therefore, objective this study was assess fetal health after a single polystyrene NP late gestation. We hypothesized acute would impair function. Pregnant rats were exposed nanopolystyrene on gestational day 19 via intratracheal instillation. 24 h later, outcomes evaluated. Cardiovascular function dams using myography ex vivo fetuses measured ultrasound. Both placental weight reduced nanopolystyrene. Increased heart aorta evident dams. Maternal led radial artery uterus, resistance vessel controls blood flow fetoplacental compartment. Function heart, aorta, umbilical dysregulated. Taken together, data suggest NPs negatively impacts health, highlighting concern MNPs pregnancy development.

Язык: Английский

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Microplastics dysregulate innate immunity in the SARS-CoV-2 infected lung

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Май 13, 2024

Introduction Global microplastic (MP) pollution is now well recognized, with humans and animals consuming inhaling MPs on a daily basis, growing body of concern surrounding the potential impacts human health. Methods Using mouse model mild COVID-19, we describe herein effects azide-free 1 μm polystyrene MP beads, co-delivered into lungs SARS-CoV-2 omicron BA.5 inoculum. The effect host response to infection was analysed using histopathology RNA-Seq at 2 6 days post-infection (dpi). Results Although reduced clearance from lung, virus titres viral RNA levels were not significantly affected by MPs, overt MP-associated clinical or histopathological changes observed. However, infected revealed that exposure suppressed innate immune responses dpi increased pro-inflammatory signatures dpi. cytokine profile showed significant correlation ‘cytokine release syndrome’ signature observed in some COVID-19 patients. Discussion findings are consistent recent finding can inhibit phagocytosis apoptotic cells via binding Tim4. They also add literature suggesting dysregulate inflammatory processes specific disease settings.

Язык: Английский

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Breathing in danger: Mapping microplastic migration in the human respiratory system

Physics of Fluids, Год журнала: 2024, Номер 36(4)

Опубликована: Апрель 1, 2024

The abundance of air pollutants over the last few years, including concentration microplastics, has become an alarming concern across world. Initially discovered in marine life, these toxic and inflammatory particles have recently been found human lung tissues. When inhaled, harmful settle down airways and, time, lead to respiratory failures. A recent study analyzed microplastic transport behavior mouth–throat airways. However, knowledge migration bifurcating tracheobronchial is missing literature. Therefore, this first-ever analyzes detail settling patterns different sizes shapes at intensities numerical technique based on discrete phase modeling employed simulate flow a three-dimensional realistic geometry. model results indicate low velocity turbulence intensity magnitudes with smooth trachea compared left right lobes, which experience higher velocities generate secondary vortices. Lower lobes are deposition hotspots for lower rate. These shift upper rate same particle size. Moreover, size shape influence overall current study, accumulation regions breathing intensities, will contribute updated pollutant inhalation facilitate relevant treatment measures.

Язык: Английский

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Micro- and nanoplastics in agricultural soils: Assessing impacts and navigating mitigation

The Science of The Total Environment, Год журнала: 2024, Номер 931, С. 172951 - 172951

Опубликована: Май 3, 2024

Micro-/nanoplastic contamination in agricultural soils raises concerns on agroecosystems and poses potential health risks. Some of have received significant amounts micro-/nanoplastics (MNPs) through plastic mulch film biosolid applications. However, a comprehensive understanding the MNP impacts plants remains elusive. The interaction between soil particles MNPs is an extremely complex issue due to different properties heterogeneity diverse characteristics MNPs. Moreover, are class relatively new anthropogenic pollutants that may negatively affect food. Herein, we presented review growth plants. We also discussed strategies for mitigating or eliminating contamination. perspectives future research highlighted.

Язык: Английский

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