The hidden threat: Unraveling the impact of microplastics on reproductive health
The Science of The Total Environment,
Год журнала:
2024,
Номер
935, С. 173177 - 173177
Опубликована: Май 13, 2024
Язык: Английский
Co-exposure of polyvinyl chloride microplastics with cadmium promotes nonalcoholic fatty liver disease in female ducks through oxidative stress and glycolipid accumulation
Poultry Science,
Год журнала:
2024,
Номер
103(11), С. 104152 - 104152
Опубликована: Авг. 5, 2024
A
recently
discovered
environmental
contaminant,
microplastics
(MPs)
are
capable
of
amassing
within
the
body
and
pose
a
grave
threat
to
health
both
humans
animals.
It
is
widely
acknowledged
that
combination
cadmium
(Cd),
hazardous
heavy
metal,
produces
synergistic
deleterious
effects.
Nevertheless,
mechanism
by
which
co-exposure
polyvinyl
chloride
(PVC-MPs)
Cd
damages
liver
avian
females
unknown.
Globally
prevalent
subject
extensive
research
in
mammals,
non-alcoholic
fatty
disease
(NAFLD)
chronic
condition.
However,
mechanisms
underlying
injury
digestive
system
caused
NAFLD
remain
Two
months
PVC-MPs,
pure
water,
solitary
exposure,
single
water
were
administered
female
Muscovy
ducks
this
study.
The
objective
was
examine
whether
duck
PVC-MPs
Cd-induced
oxidative
stress
resulted
subsequent
apoptosis
hepatic
cells.
study's
findings
showed
hepatocyte
shape
functional
activity
negatively
impacted
PVC-MP
buildup
tissues.
Reduced
organ
coefficients,
increased
alanine
aminotransferase
(ALT)
content,
ultrastructural
damage
nuclei
mitochondria
indicators
this.
These
results
point
possible
impairment
function.
phosphoenolpyruvate
carboxykinase
1
(PCK1)
deficiency
activates
protein
kinase
B/phosphatidylinositol
3-kinase
(PI3K/AKT)
pathway
livers
reproductive
have
been
damaged
stress.
This
stimulation
induces
lipid
deposition,
fibrosis,
glycogen
accumulation,
ultimately
apoptosis.
In
summary,
our
provides
evidence
cause
harm
liver,
subsequently
fibrosis
tissue,
glucolipid
metabolism,
Язык: Английский
Microplastics in the marine environment: Impacts, identification and treatments
Bioresource Technology Reports,
Год журнала:
2025,
Номер
unknown, С. 102073 - 102073
Опубликована: Фев. 1, 2025
Язык: Английский
Research Progress on Micro(nano)plastic-Induced Programmed Cell Death Associated with Disease Risks
Toxics,
Год журнала:
2024,
Номер
12(7), С. 493 - 493
Опубликована: Июль 5, 2024
Due
to
their
robust
migration
capabilities,
slow
degradation,
and
propensity
for
adsorbing
environmental
pollutants,
micro(nano)plastics
(MNPs)
are
pervasive
across
diverse
ecosystems.
They
infiltrate
various
organisms
within
different
food
chains
through
multiple
pathways
including
inhalation
dermal
contact,
pose
a
significant
challenge
in
the
21st
century.
Research
indicates
that
MNPs
health
threats
broad
range
of
organisms,
humans.
Currently,
extensive
detection
data
studies
using
experimental
animals
vitro
cell
culture
indicate
can
trigger
forms
programmed
death
(PCD)
induce
diseases.
This
review
provides
comprehensive
systematic
analysis
MNP-induced
PCD
processes,
pyroptosis,
ferroptosis,
autophagy,
necroptosis,
apoptosis,
based
on
recent
research
findings
focuses
elucidating
links
between
Additionally,
targeted
therapeutic
interventions
these
diseases
described.
original
insights
into
opportunities
challenges
posed
by
current
findings.
evaluates
ways
mitigate
resulting
from
patterns.
Moreover,
this
paper
enhances
understanding
biohazards
associated
with
providing
reference
subsequent
toxicological
risk
mitigation
efforts.
Язык: Английский
Impact of photoaging on the chemical and cytotoxic properties of nanoscale zeolitic imidazolate framework-8
Journal of Hazardous Materials,
Год журнала:
2024,
Номер
479, С. 135536 - 135536
Опубликована: Авг. 15, 2024
Язык: Английский
Air pollutants as modulators of mitochondrial quality control in cardiovascular disease
Physiological Reports,
Год журнала:
2024,
Номер
12(22)
Опубликована: Ноя. 1, 2024
Abstract
It
is
important
to
understand
the
effects
of
environmental
factors
such
as
air
pollution
on
mitochondrial
structure
and
function,
especially
when
these
changes
increase
cardiovascular
disease
risk.
Although
lifestyle
choices
directly
determine
many
diseases,
increasingly,
it
becoming
clear
that
function
mitochondria
may
be
affected
by
pollutants
found
in
atmosphere
(e.g.,
gases,
pesticides
herbicide
aerosols,
or
microparticles).
To
date,
role
agents
potential
impact
fitness
neglected.
Here
we
offer
a
review
airborne
stressors
pollutants,
contribute
impairments
cause
heart
disease.
Язык: Английский