Polystyrene microplastics trigger testosterone decline via GPX1
The Science of The Total Environment,
Год журнала:
2024,
Номер
947, С. 174536 - 174536
Опубликована: Июль 6, 2024
Язык: Английский
Corneal Mucin‐Targeting Liposome Nanoplatforms Enable Effective Treatment of Dry Eye Diseases by Integrated Regulation of Ferroptosis and Inflammation
Advanced Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 28, 2024
Abstract
The
incidence
of
dry
eye
disease
(DED)
has
been
increasing
annually
worldwide,
creating
an
urgent
need
for
new
therapies.
Due
to
the
multifactorial
mechanism
underlying
DED,
traditional
medications
focused
on
decreasing
ocular
surface
inflammation
have
unable
address
all
harmful
factors
and
fail
achieve
a
complete
clinical
cure.
Ferroptosis,
form
programmed
cell
death
characterized
by
lipid
peroxidation,
become
pivotal
contributor
oxidative
stress‐driven
pathology.
Therefore,
therapeutic
targeting
ferroptosis
may
be
attractive
option
management.
Herein,
sialic
acid‐targeting
peptide‐modified
liposome
loaded
with
Cyclosporine
A
(CsA),
typical
anti‐inflammatory
drug,
Ferrostatin‐1
(Fer‐1),
selective
inhibitor,
is
developed
termed
as
CF@SNPs,
combing
sustaining
DED
treatment.
This
multifunctional
liposomal
encapsulation
demonstrates
excellent
aqueous
solubility;
moreover,
peptide
prolongs
retention,
further
enhancing
efficacy.
CF@SNPs
treatment
comprehensively
alleviates
symptoms,
including
improving
corneal
defects,
augmenting
goblet
count,
restoring
tear
secretion.
Specifically,
attenuate
pathology
suppressing
p53‐SLC7A11‐GSH‐dependent
TNF‐α‐associated
inflammatory
cascades,
accompanied
favorable
biocompatibility
in
vivo.
These
results
underscore
promising
potential
this
superior
nano‐formulation
pharmacotherapy.
Язык: Английский
Toxicological assessments based on intestine 3D organoids reveal environmental low-dose nanosized microplastics (NPs) exposure aggravates radiation-induced intestine injury
Chemosphere,
Год журнала:
2024,
Номер
370, С. 143922 - 143922
Опубликована: Дек. 18, 2024
Язык: Английский
Unmasking the Invisible Threat: Biological Impacts and Mechanisms of Polystyrene Nanoplastics on Cells
Toxics,
Год журнала:
2024,
Номер
12(12), С. 908 - 908
Опубликована: Дек. 14, 2024
Polystyrene
nanoplastics
(PS-NPs),
a
pervasive
component
of
plastic
pollution,
have
emerged
as
significant
environmental
and
health
threat
due
to
their
microscopic
size
bioaccumulative
properties.
This
review
systematically
explores
the
biological
effects
mechanisms
PS-NPs
on
cellular
systems,
encompassing
oxidative
stress,
mitochondrial
dysfunction,
DNA
damage,
inflammation,
disruptions
in
autophagy.
Notably,
induce
multiple
forms
cell
death,
including
apoptosis,
ferroptosis,
necroptosis,
pyroptosis,
mediated
through
distinct
yet
interconnected
molecular
pathways.
The
also
highlights
various
factors
that
influence
cytotoxicity
PS-NPs,
such
particle
size,
surface
modifications,
co-exposure
with
other
pollutants,
protein
corona
formation.
These
complex
interactions
underscore
extensive
potentially
hazardous
impacts
health.
findings
presented
here
emphasize
need
for
continued
research
underlying
PS-NP
toxicity
development
effective
strategies
mitigating
effects,
thereby
informing
regulatory
frameworks
aimed
at
minimizing
risks.
Язык: Английский