Unmasking the Invisible Threat: Biological Impacts and Mechanisms of Polystyrene Nanoplastics on Cells DOI Creative Commons

Wenxia Bu,

Cui Ye, Yan Jin

et al.

Toxics, Journal Year: 2024, Volume and Issue: 12(12), P. 908 - 908

Published: Dec. 14, 2024

Polystyrene nanoplastics (PS-NPs), a pervasive component of plastic pollution, have emerged as significant environmental and health threat due to their microscopic size bioaccumulative properties. This review systematically explores the biological effects mechanisms PS-NPs on cellular systems, encompassing oxidative stress, mitochondrial dysfunction, DNA damage, inflammation, disruptions in autophagy. Notably, induce multiple forms cell death, including apoptosis, ferroptosis, necroptosis, pyroptosis, mediated through distinct yet interconnected molecular pathways. The also highlights various factors that influence cytotoxicity PS-NPs, such particle size, surface modifications, co-exposure with other pollutants, protein corona formation. These complex interactions underscore extensive potentially hazardous impacts health. findings presented here emphasize need for continued research underlying PS-NP toxicity development effective strategies mitigating effects, thereby informing regulatory frameworks aimed at minimizing risks.

Language: Английский

Polystyrene microplastics trigger testosterone decline via GPX1 DOI
Jiayuan Qu,

Liling Wu,

Li Mou

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 947, P. 174536 - 174536

Published: July 6, 2024

Language: Английский

Citations

4
Corneal Mucin‐Targeting Liposome Nanoplatforms Enable Effective Treatment of Dry Eye Diseases by Integrated Regulation of Ferroptosis and Inflammation DOI Creative Commons
Yin Zhang,

Tinglian Zhou,

Kai Wang

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 28, 2024

Abstract The incidence of dry eye disease (DED) has been increasing annually worldwide, creating an urgent need for new therapies. Due to the multifactorial mechanism underlying DED, traditional medications focused on decreasing ocular surface inflammation have unable address all harmful factors and fail achieve a complete clinical cure. Ferroptosis, form programmed cell death characterized by lipid peroxidation, become pivotal contributor oxidative stress‐driven pathology. Therefore, therapeutic targeting ferroptosis may be attractive option management. Herein, sialic acid‐targeting peptide‐modified liposome loaded with Cyclosporine A (CsA), typical anti‐inflammatory drug, Ferrostatin‐1 (Fer‐1), selective inhibitor, is developed termed as CF@SNPs, combing sustaining DED treatment. This multifunctional liposomal encapsulation demonstrates excellent aqueous solubility; moreover, peptide prolongs retention, further enhancing efficacy. CF@SNPs treatment comprehensively alleviates symptoms, including improving corneal defects, augmenting goblet count, restoring tear secretion. Specifically, attenuate pathology suppressing p53‐SLC7A11‐GSH‐dependent TNF‐α‐associated inflammatory cascades, accompanied favorable biocompatibility in vivo. These results underscore promising potential this superior nano‐formulation pharmacotherapy.

Language: Английский

Citations

2
Toxicological assessments based on intestine 3D organoids reveal environmental low-dose nanosized microplastics (NPs) exposure aggravates radiation-induced intestine injury DOI

Peiyu Guo,

Chenjun Bai,

Lihui Xuan

et al.

Chemosphere, Journal Year: 2024, Volume and Issue: 370, P. 143922 - 143922

Published: Dec. 18, 2024

Language: Английский

Citations

0
Unmasking the Invisible Threat: Biological Impacts and Mechanisms of Polystyrene Nanoplastics on Cells DOI Creative Commons

Wenxia Bu,

Cui Ye, Yan Jin

et al.

Toxics, Journal Year: 2024, Volume and Issue: 12(12), P. 908 - 908

Published: Dec. 14, 2024

Polystyrene nanoplastics (PS-NPs), a pervasive component of plastic pollution, have emerged as significant environmental and health threat due to their microscopic size bioaccumulative properties. This review systematically explores the biological effects mechanisms PS-NPs on cellular systems, encompassing oxidative stress, mitochondrial dysfunction, DNA damage, inflammation, disruptions in autophagy. Notably, induce multiple forms cell death, including apoptosis, ferroptosis, necroptosis, pyroptosis, mediated through distinct yet interconnected molecular pathways. The also highlights various factors that influence cytotoxicity PS-NPs, such particle size, surface modifications, co-exposure with other pollutants, protein corona formation. These complex interactions underscore extensive potentially hazardous impacts health. findings presented here emphasize need for continued research underlying PS-NP toxicity development effective strategies mitigating effects, thereby informing regulatory frameworks aimed at minimizing risks.

Language: Английский

Citations

0