Therapeutic strategies of targeting non-apoptotic regulated cell death (RCD) with small-molecule compounds in cancer DOI Creative Commons
Xin Jin,

Wenke Jin,

L. Tong

и другие.

Acta Pharmaceutica Sinica B, Год журнала: 2024, Номер 14(7), С. 2815 - 2853

Опубликована: Апрель 24, 2024

Regulated cell death (RCD) is a controlled form of orchestrated by one or more cascading signaling pathways, making it amenable to pharmacological intervention. RCD subroutines can be categorized as apoptotic non-apoptotic and play essential roles in maintaining homeostasis, facilitating development, modulating immunity. Accumulating evidence has recently revealed that evasion frequently the primary cause tumor survival. Several have garnered attention promising cancer therapies due their ability induce regression prevent relapse, comparable apoptosis. Moreover, they offer potential solutions for overcoming acquired resistance tumors toward drugs. With an increasing understanding underlying mechanisms governing these subroutines, growing number small-molecule compounds targeting single multiple pathways been discovered, providing novel strategies current therapy. In this review, we comprehensively summarized regulatory emerging mainly including autophagy-dependent death, ferroptosis, cuproptosis, disulfidptosis, necroptosis, pyroptosis, alkaliptosis, oxeiptosis, parthanatos, mitochondrial permeability transition (MPT)-driven necrosis, entotic NETotic lysosome-dependent immunogenic (ICD). Furthermore, focused on discussing related compounds. brief, insightful findings may provide valuable guidance investigating individual collaborative approaches towards different ultimately driving discovery target significantly enhance future therapeutics.

Язык: Английский

Dissecting the pleiotropic roles of reactive oxygen species (ROS) in lung cancer: From carcinogenesis toward therapy DOI
Ying Hou, Heng Wang, Jiarui Wu

и другие.

Medicinal Research Reviews, Год журнала: 2024, Номер 44(4), С. 1566 - 1595

Опубликована: Янв. 29, 2024

Lung cancer is a major cause of morbidity and mortality. The specific pulmonary structure to directly connect with ambient air makes it more susceptible damage from airborne toxins. External oxidative stimuli endogenous reactive oxygen species (ROS) play crucial role in promoting lung carcinogenesis development. biological properties higher ROS levels tumor cells than normal make them sensitive vulnerable injury. Therefore, the strategy targeting has been proposed for therapy decades. However, embarrassing that countless attempts at ROS-based therapies have had very limited success, no FDA approval anticancer list was mechanistically based on manipulation. Even compared untargetable proteins, such as transcription factors, are difficult be targeted due their chemical properties. Thus, pleiotropic roles provide therapeutic potential drug discovery, while better dissection mechanistic action signaling pathways prerequisite future breakthroughs. This review discusses critical carcinogenesis, ROS-inspired pathways, treatment, exemplified by cancer. In particular, an eight considerations rule ROS-targeting strategies design

Язык: Английский

Процитировано

12
Polyphenol-Loaded Nano-carriers for Breast Cancer Therapy: A Comprehensive Review DOI
Asif Ahmad Bhat, Gaurav Gupta, Muhammad Afzal

и другие.

BioNanoScience, Год журнала: 2024, Номер 14(4), С. 4219 - 4237

Опубликована: Янв. 10, 2024

Язык: Английский

Процитировано

11
Mechanistic insights into circRNA-mediated regulation of PI3K signaling pathway in glioma progression DOI
Alireza Mafi, Seyedeh Mahdieh Khoshnazar,

Amirhossein Shahpar

и другие.

Pathology - Research and Practice, Год журнала: 2024, Номер 260, С. 155442 - 155442

Опубликована: Июль 1, 2024

Язык: Английский

Процитировано

11
Soy isoflavones induces mitophagy to inhibit the progression of osteosarcoma by blocking the AKT/mTOR signaling pathway DOI Creative Commons

Ziang Zheng,

Xinghan Zhao,

Bo Yuan

и другие.

Molecular Medicine, Год журнала: 2024, Номер 30(1)

Опубликована: Янв. 8, 2024

Abstract Background Soy isoflavones (SI) is a natural bioactive substance exhibiting beneficial effects on human health. This study aims to elucidate the therapeutic potential of SI in treatment osteosarcoma (OS) and investigate underlying mechanisms, particularly focusing mitophagy. Methods The proliferation, apoptosis, migration, invasion U2OS cells were analyzed. Mitophagy was assessed through multiple parameters: mitochondrial autophagosomes, membrane potential, autophagy-related proteins, reactive oxygen species (ROS), consumption rate (OCR). Protein levels related autophagy, AKT/mTOR pathway analyzed using western blot. efficacy further identified mouse tumor xenograft model. Cell apoptosis proliferation xenografts detected by TUNEL staining immunohistochemistry (IHC), respectively. Results dose-dependently suppressed viability, colony formation, cells, enhanced apoptosis. also induced mitophagy OS evidenced an increase autophagosomes ROS levels, decrease OCR, concomitant changes proteins. Mdivi-1, inhibitor mitophagy, reversed anti-tumor cells. In addition, blocked SC-79, AKT agonist, effect inducing Moreover, promoted cell vivo . Conclusions induces blocking pathway, contributing inhibition OS.

Язык: Английский

Процитировано

10
Therapeutic strategies of targeting non-apoptotic regulated cell death (RCD) with small-molecule compounds in cancer DOI Creative Commons
Xin Jin,

Wenke Jin,

L. Tong

и другие.

Acta Pharmaceutica Sinica B, Год журнала: 2024, Номер 14(7), С. 2815 - 2853

Опубликована: Апрель 24, 2024

Regulated cell death (RCD) is a controlled form of orchestrated by one or more cascading signaling pathways, making it amenable to pharmacological intervention. RCD subroutines can be categorized as apoptotic non-apoptotic and play essential roles in maintaining homeostasis, facilitating development, modulating immunity. Accumulating evidence has recently revealed that evasion frequently the primary cause tumor survival. Several have garnered attention promising cancer therapies due their ability induce regression prevent relapse, comparable apoptosis. Moreover, they offer potential solutions for overcoming acquired resistance tumors toward drugs. With an increasing understanding underlying mechanisms governing these subroutines, growing number small-molecule compounds targeting single multiple pathways been discovered, providing novel strategies current therapy. In this review, we comprehensively summarized regulatory emerging mainly including autophagy-dependent death, ferroptosis, cuproptosis, disulfidptosis, necroptosis, pyroptosis, alkaliptosis, oxeiptosis, parthanatos, mitochondrial permeability transition (MPT)-driven necrosis, entotic NETotic lysosome-dependent immunogenic (ICD). Furthermore, focused on discussing related compounds. brief, insightful findings may provide valuable guidance investigating individual collaborative approaches towards different ultimately driving discovery target significantly enhance future therapeutics.

Язык: Английский

Процитировано

10