Inflammopharmacology, Год журнала: 2025, Номер unknown
Опубликована: Фев. 16, 2025
Язык: Английский
Colloids and Surfaces B Biointerfaces, Год журнала: 2023, Номер 225, С. 113231 - 113231
Опубликована: Фев. 28, 2023
Язык: Английский
Процитировано
19
Pharmaceuticals, Год журнала: 2023, Номер 16(6), С. 783 - 783
Опубликована: Май 24, 2023
The transcription factor nuclear factor-κB (NF-κB) plays a complicated role in multiple tumors. Mounting evidence demonstrates that NF-κB activation supports tumorigenesis and development by enhancing cell proliferation, invasion, metastasis, preventing death, facilitating angiogenesis, regulating tumor immune microenvironment metabolism, inducing therapeutic resistance. Notably, functions as double-edged sword exerting positive or negative influences on cancers. In this review, we summarize discuss recent research the regulation of cancer deaths, therapy resistance, NF-κB-based nano delivery systems.
Язык: Английский
Процитировано
19
Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2024, Номер unknown
Опубликована: Авг. 28, 2024
Язык: Английский
Процитировано
8
Frontiers in Bioengineering and Biotechnology, Год журнала: 2024, Номер 11
Опубликована: Янв. 11, 2024
Increasing bacterial resistance and the negative impact of currently used antibacterial agents have produced need for novel anticancer drugs. In this regard, nanotechnology could provide safer more efficient therapeutic agents. The main methods nanoparticle production are chemical physical approaches that often costly environmentally unsafe. current study, Pluchea indica leaf extract was biosynthesis bimetallic selenium–gold nanoparticles (Se-Au BNPs) first time. Phytochemical examinations revealed P. includes 90.25 mg/g dry weight (DW) phenolics, 275.53 DW flavonoids, 26.45 tannins. X-ray diffraction (XRD), transmission electron microscopy (TEM), Fourier-transform infrared (FTIR) spectroscopy, dynamic light scattering (DLS), scanning (SEM), energy-dispersive spectroscopy (EDX) techniques were employed to characterize Se-Au BNPs. Based on UV-vis spectra, absorbance BNPs peaked at 238 374 nm. SEM imaging, emerged as bright particles, both Au Se uniformly distributed throughout extract. XRD analysis average size 45.97 showed properties against Escherichia coli , Pseudomonas aeruginosa Staphylococcus aureus Bacillus subtilis with minimum inhibitory concentrations (MICs) 31.25, 15.62, 3.9 μg/mL, respectively. Surprisingly, a cytotoxicity assay IC 50 value toward Wi 38 normal cell line 116.8 implying all MICs described above be safely. More importantly, shown higher efficacy human breast cancer cells (MCF7), an 13.77 μg/mL. conclusion, paper is data effective utilization in biologically active
Язык: Английский
Процитировано
7
Biomedicine & Pharmacotherapy, Год журнала: 2022, Номер 155, С. 113740 - 113740
Опубликована: Сен. 24, 2022
Despite conventional treatment options including chemoradiation, patients with the most aggressive primary brain tumor, glioblastoma multiforme (GBM), experience an average survival time of less than 15 months. Regarding malignant nature GBM, extensive research and discovery novel treatments are urgently required to improve patients' prognosis. Autophagy, a crucial physiological pathway for degradation recycling cell components, is one exciting targets GBM studies. Interventions aimed at autophagy activation or inhibition have been explored as potential therapeutics. This review, which delves into therapeutic techniques block activate in preclinical clinical research, aims expand our understanding available therapies battling GBM.
Язык: Английский
Процитировано
25
Journal of Functional Foods, Год журнала: 2022, Номер 96, С. 105192 - 105192
Опубликована: Июль 28, 2022
• Solid tumors rely on pathological angiogenesis to meet their metabolic needs and facilitate spread. Glioblastoma multiforme (GBM), an aggressive deadliest brain malignancy, is represented by multi-mechanistic exuberant angiogenic properties. The current study summarized advances in the preclinical clinical investigations concerning impact of phytochemicals GBM tumor focusing mechanism action. Current treatment efforts inhibit neovascularization using monoclonal antibodies (e.g., bevacizumab) generally fail enhance patients’ lifespan due inadequate medication transport lack a multimodal action accentuating necessity developing novel medicines. Phytochemicals such as curcumin, ellagic acid, quercetin, resveratrol are secondary metabolites plants that have frequently been demonstrated enclose potential suppressing growth through inhibiting various mechanisms involved neovessel creation. Furthermore, we sought identify overlooked factors for future research.
Язык: Английский
Процитировано
23
Cancer Nanotechnology, Год журнала: 2023, Номер 14(1)
Опубликована: Май 29, 2023
Abstract Glioma is the most prevalent type of primary brain tumor, and glioblastoma multiforme (GBM) highest deadly central nervous system (CNS) affecting a significant number patients each year, with median overall survival approximately 14.6 months after diagnosis. Despite intensive treatment, nearly all GBM experience recurrence, 5-year rate about 5%. The protective BBB high tumor heterogeneity prevent effective delivery drugs, resulting in treatment failure various drugs. emergence nanometer-scale diagnosis methods has provided new promising approaches to overcome these difficulties. Thus, our review focuses on development BBB-crossing nanomedicine-enhanced chemotherapy combined therapy applications for glioma. Meanwhile, we also reviewed strategies blood–brain barrier. Additionally, discuss recent achievements area nanomedicine rational design approach, which will offer recommendations anti-GBM development.
Язык: Английский
Процитировано
16
Advanced Functional Materials, Год журнала: 2024, Номер 34(49)
Опубликована: Авг. 24, 2024
Abstract Immunoregulatory strategies for activating or inhibiting immune responses have emerged as a promising approach treating tumors and immune‐related inflammatory diseases. Nanomaterials, also known their inherent immunoregulatory capacity, are extensively investigated potential in immunotherapy. Among these nanomaterials, fullerene‐based nanomaterials with unique properties attracted considerable attention use In this study, comprehensive review of the recent research progress on is presented. It illustrates specific mechanism activation using fullerene reviews applications tumor immunotherapy tumor‐enhancement Now introduces molecular over‐activated inflammation. Herein, different negative developed to inhibit Additionally, current challenges prospects developing efficient clinical usage discussed.
Язык: Английский
Процитировано
5
European Polymer Journal, Год журнала: 2022, Номер 184, С. 111784 - 111784
Опубликована: Дек. 20, 2022
Язык: Английский
Процитировано
21
Pharmaceutics, Год журнала: 2023, Номер 15(6), С. 1692 - 1692
Опубликована: Июнь 9, 2023
Tumor development, progression, and resistance to therapies are influenced by the interactions between tumor cells surrounding microenvironment, comprising fibroblasts, immune cells, extracellular matrix proteins. In this context, mast (MCs) have recently emerged as important players. Yet, their role is still controversial, MCs can exert pro- or anti-tumor functions in different types depending on location within around mass interaction with other components of microenvironment. review, we describe main aspects MC biology contribution promoting inhibiting cancer growth. We then discuss possible therapeutic strategies aimed at targeting for immunotherapy, which include: (1) c-Kit signaling; (2) stabilizing degranulation; (3) triggering activating/inhibiting receptors; (4) modulating recruitment; (5) harnessing mediators; (6) adoptive transferring MCs. Such should aim either restrain sustain activity according specific contexts. Further investigation would allow us better dissect multifaceted roles tailor novel approaches an “MC-guided” personalized medicine be used combination conventional anti-cancer therapies.
Язык: Английский
Процитировано
12