Small Methods,
Journal Year:
2023,
Volume and Issue:
8(8)
Published: Dec. 1, 2023
Immune
checkpoint
blockade
(ICB)
therapy
for
tumors
has
arisen
in
growing
interest.
However,
the
low
response
rate
of
to
ICB
is
mainly
attributed
inhibitory
infiltration
immune
cells
tumor
microenvironment
(TME).
Despite
promising
benefits
ICB,
therapeutic
effects
antibodies
are
dependent
on
a
high
dose
and
long-term
usage
clinic,
thereby
leading
immune-related
adverse
effects.
Accordingly,
combined
with
nano-delivery
systems
could
be
used
overcome
T
cell
exhaustion,
which
reduces
side
higher
rates
patients.
In
this
review,
authors
aim
exhaustion
TME
via
modulation
enhanced
immunotherapy.
Several
strategies
summarized
combine
further
enhance
immunotherapy:
a)
expressing
surface
systems;
b)
loading
inhibitors
into
c)
gene-editing
technology
d)
mediated
modulation.
Taken
together,
might
strategy
Pharmaceuticals,
Journal Year:
2023,
Volume and Issue:
16(6), P. 783 - 783
Published: May 24, 2023
The
transcription
factor
nuclear
factor-κB
(NF-κB)
plays
a
complicated
role
in
multiple
tumors.
Mounting
evidence
demonstrates
that
NF-κB
activation
supports
tumorigenesis
and
development
by
enhancing
cell
proliferation,
invasion,
metastasis,
preventing
death,
facilitating
angiogenesis,
regulating
tumor
immune
microenvironment
metabolism,
inducing
therapeutic
resistance.
Notably,
functions
as
double-edged
sword
exerting
positive
or
negative
influences
on
cancers.
In
this
review,
we
summarize
discuss
recent
research
the
regulation
of
cancer
deaths,
therapy
resistance,
NF-κB-based
nano
delivery
systems.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2024,
Volume and Issue:
11
Published: Jan. 11, 2024
Increasing
bacterial
resistance
and
the
negative
impact
of
currently
used
antibacterial
agents
have
produced
need
for
novel
anticancer
drugs.
In
this
regard,
nanotechnology
could
provide
safer
more
efficient
therapeutic
agents.
The
main
methods
nanoparticle
production
are
chemical
physical
approaches
that
often
costly
environmentally
unsafe.
current
study,
Pluchea
indica
leaf
extract
was
biosynthesis
bimetallic
selenium–gold
nanoparticles
(Se-Au
BNPs)
first
time.
Phytochemical
examinations
revealed
P.
includes
90.25
mg/g
dry
weight
(DW)
phenolics,
275.53
DW
flavonoids,
26.45
tannins.
X-ray
diffraction
(XRD),
transmission
electron
microscopy
(TEM),
Fourier-transform
infrared
(FTIR)
spectroscopy,
dynamic
light
scattering
(DLS),
scanning
(SEM),
energy-dispersive
spectroscopy
(EDX)
techniques
were
employed
to
characterize
Se-Au
BNPs.
Based
on
UV-vis
spectra,
absorbance
BNPs
peaked
at
238
374
nm.
SEM
imaging,
emerged
as
bright
particles,
both
Au
Se
uniformly
distributed
throughout
extract.
XRD
analysis
average
size
45.97
showed
properties
against
Escherichia
coli
,
Pseudomonas
aeruginosa
Staphylococcus
aureus
Bacillus
subtilis
with
minimum
inhibitory
concentrations
(MICs)
31.25,
15.62,
3.9
μg/mL,
respectively.
Surprisingly,
a
cytotoxicity
assay
IC
50
value
toward
Wi
38
normal
cell
line
116.8
implying
all
MICs
described
above
be
safely.
More
importantly,
shown
higher
efficacy
human
breast
cancer
cells
(MCF7),
an
13.77
μg/mL.
conclusion,
paper
is
data
effective
utilization
in
biologically
active
Biomedicine & Pharmacotherapy,
Journal Year:
2022,
Volume and Issue:
155, P. 113740 - 113740
Published: Sept. 24, 2022
Despite
conventional
treatment
options
including
chemoradiation,
patients
with
the
most
aggressive
primary
brain
tumor,
glioblastoma
multiforme
(GBM),
experience
an
average
survival
time
of
less
than
15
months.
Regarding
malignant
nature
GBM,
extensive
research
and
discovery
novel
treatments
are
urgently
required
to
improve
patients'
prognosis.
Autophagy,
a
crucial
physiological
pathway
for
degradation
recycling
cell
components,
is
one
exciting
targets
GBM
studies.
Interventions
aimed
at
autophagy
activation
or
inhibition
have
been
explored
as
potential
therapeutics.
This
review,
which
delves
into
therapeutic
techniques
block
activate
in
preclinical
clinical
research,
aims
expand
our
understanding
available
therapies
battling
GBM.
Journal of Functional Foods,
Journal Year:
2022,
Volume and Issue:
96, P. 105192 - 105192
Published: July 28, 2022
•
Solid
tumors
rely
on
pathological
angiogenesis
to
meet
their
metabolic
needs
and
facilitate
spread.
Glioblastoma
multiforme
(GBM),
an
aggressive
deadliest
brain
malignancy,
is
represented
by
multi-mechanistic
exuberant
angiogenic
properties.
The
current
study
summarized
advances
in
the
preclinical
clinical
investigations
concerning
impact
of
phytochemicals
GBM
tumor
focusing
mechanism
action.
Current
treatment
efforts
inhibit
neovascularization
using
monoclonal
antibodies
(e.g.,
bevacizumab)
generally
fail
enhance
patients’
lifespan
due
inadequate
medication
transport
lack
a
multimodal
action
accentuating
necessity
developing
novel
medicines.
Phytochemicals
such
as
curcumin,
ellagic
acid,
quercetin,
resveratrol
are
secondary
metabolites
plants
that
have
frequently
been
demonstrated
enclose
potential
suppressing
growth
through
inhibiting
various
mechanisms
involved
neovessel
creation.
Furthermore,
we
sought
identify
overlooked
factors
for
future
research.
Cancer Nanotechnology,
Journal Year:
2023,
Volume and Issue:
14(1)
Published: May 29, 2023
Abstract
Glioma
is
the
most
prevalent
type
of
primary
brain
tumor,
and
glioblastoma
multiforme
(GBM)
highest
deadly
central
nervous
system
(CNS)
affecting
a
significant
number
patients
each
year,
with
median
overall
survival
approximately
14.6
months
after
diagnosis.
Despite
intensive
treatment,
nearly
all
GBM
experience
recurrence,
5-year
rate
about
5%.
The
protective
BBB
high
tumor
heterogeneity
prevent
effective
delivery
drugs,
resulting
in
treatment
failure
various
drugs.
emergence
nanometer-scale
diagnosis
methods
has
provided
new
promising
approaches
to
overcome
these
difficulties.
Thus,
our
review
focuses
on
development
BBB-crossing
nanomedicine-enhanced
chemotherapy
combined
therapy
applications
for
glioma.
Meanwhile,
we
also
reviewed
strategies
blood–brain
barrier.
Additionally,
discuss
recent
achievements
area
nanomedicine
rational
design
approach,
which
will
offer
recommendations
anti-GBM
development.
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(6), P. 1692 - 1692
Published: June 9, 2023
Tumor
development,
progression,
and
resistance
to
therapies
are
influenced
by
the
interactions
between
tumor
cells
surrounding
microenvironment,
comprising
fibroblasts,
immune
cells,
extracellular
matrix
proteins.
In
this
context,
mast
(MCs)
have
recently
emerged
as
important
players.
Yet,
their
role
is
still
controversial,
MCs
can
exert
pro-
or
anti-tumor
functions
in
different
types
depending
on
location
within
around
mass
interaction
with
other
components
of
microenvironment.
review,
we
describe
main
aspects
MC
biology
contribution
promoting
inhibiting
cancer
growth.
We
then
discuss
possible
therapeutic
strategies
aimed
at
targeting
for
immunotherapy,
which
include:
(1)
c-Kit
signaling;
(2)
stabilizing
degranulation;
(3)
triggering
activating/inhibiting
receptors;
(4)
modulating
recruitment;
(5)
harnessing
mediators;
(6)
adoptive
transferring
MCs.
Such
should
aim
either
restrain
sustain
activity
according
specific
contexts.
Further
investigation
would
allow
us
better
dissect
multifaceted
roles
tailor
novel
approaches
an
“MC-guided”
personalized
medicine
be
used
combination
conventional
anti-cancer
therapies.
