The Involvement of Cysteine-X-Cysteine Motif Chemokine Receptors in Skin Homeostasis and the Pathogenesis of Allergic Contact Dermatitis and Psoriasis

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(2), С. 1005 - 1005

Опубликована: Янв. 13, 2024

Members of the C-X-C motif chemokine receptor (CXCR) superfamily play central roles in initiating innate immune response mammalian cells by orchestrating selective cell migration and activation. With its multilayered structure, skin, which is largest organ body, performs a crucial defense function, protecting human body from harmful environmental threats pathogens. CXCRs contribute to primary immunological defense; these receptors are differentially expressed different types skin act as key players downstream responses. While initiation inflammatory responses essential for pathogen elimination tissue healing, overactivation can enhance T-cell-mediated autoimmune responses, resulting excessive inflammation development several disorders, including psoriasis, atopic dermatitis, allergic contact vitiligo, diseases, cancers. In summary, serve critical links that connect immunity adaptive immunity. this article, we present current knowledge about functions homeostasis function their contributions pathogenesis dermatitis psoriasis. Furthermore, will examine research progress efficacy therapeutic approaches target CXCRs.

Язык: Английский

---

Epigenetic Modifications in Prostate Cancer Metastasis and Microenvironment

Cancers, Год журнала: 2023, Номер 15(8), С. 2243 - 2243

Опубликована: Апрель 11, 2023

The gradual evolution of prostate tissue from benign tumor to malignant lesion or distant metastasis is driven by intracellular epigenetic changes and the microenvironment remodeling. With continuous study modifications, these tumor-driving forces are being discovered providing new treatments for cancer. Here we introduce classification modification highlight role in remodeling communication microenvironment.

Язык: Английский

---

Notch3-regulated microRNAs impair CXCR4-dependent maturation of thymocytes allowing maintenance and progression of T-ALL

Oncogene, Год журнала: 2024, Номер 43(34), С. 2535 - 2547

Опубликована: Июнь 21, 2024

Язык: Английский

---

Banxia-Shengjiang drug pair inhibits gastric cancer development and progression by improving body immunity

Medicine, Год журнала: 2024, Номер 103(10), С. e36303 - e36303

Опубликована: Март 8, 2024

To investigate the mechanism of action Banxia-Shengjiang drug pair on inhibition gastric cancer (GC) using network pharmacology and bioinformatics techniques. The targets Banxia ( Pinellia ternata (Thunb.) Makino ) -Shengjiang Zingiber officinale Roscoe obtained from TCMSP database were intersected with differentially expressed genes (DEGs) GC-related genes, analyzed for pathway enrichment to identify signaling pathways core target genes. Subsequently, clinical relevance gene mutation analysis, methylation immune infiltration analysis cell analysis. Finally, by constructing PPI hub corresponding active ingredients, key ingredients screened molecular docking In this study, a total 557 pairs, 7754 1799 DEGs in GC screened. Five screened, which PTGS2, MMP9, PPARG, MMP2, CXCR4. analyses showed that intersecting associated RAS/MAPK pathway. addition, correlation was closely immunotherapy. results single nucleotide variation (SNV) copy number (CNV) indicated mutations survival patients. PTGS2 MMP9 potentially important pair, while cavidine an ingredient pair. may regulate function inhibit modulating expression such as pathway, MMP9.

Язык: Английский

---

Development and therapeutic perspectives of CXCR4 antagonists for disease therapy

European Journal of Medicinal Chemistry, Год журнала: 2024, Номер 275, С. 116594 - 116594

Опубликована: Июнь 11, 2024

Язык: Английский

---

CXC chemokine receptor 4 ‐ mediated immune modulation and tumor microenvironment heterogeneity in gastric cancer: Utilizing multi‐omics approaches to identify potential therapeutic targets

BioFactors, Год журнала: 2024, Номер unknown

Опубликована: Окт. 21, 2024

Abstract G‐protein‐coupled receptors (GPRs) are critical regulators of various biological behaviors, and their role in gastric cancer (GC) progression is gaining increasing attention. Among them, the immune regulatory mechanisms mediated by chemokine receptor 4 (CXCR4) remain insufficiently understood. This study aims to explore functions CXCR4 heterogeneity tumor microenvironment (TME) examining GPR‐related gene expression GC. Through multi‐omics approaches, including spatial transcriptomics single‐cell RNA sequencing, we investigated oncogenic CXCR4, particularly its T cell exhaustion. In vitro experiments, ELISA, PCR, CCK8 assays, scratch colony formation were used validate migration invasion AGS SNU‐1 lines. silencing using siRNA further demonstrated effects on these cellular processes. Our results revealed a strong correlation between elevated increased exhaustion cells (Tregs) TME. Furthermore, heightened was linked TME heterogeneity, driven oxidative stress activation NF‐κB pathway, promoting evasion progression. Silencing significantly inhibited invasive proliferative abilities cells, while also reducing pro‐inflammatory cytokines IL‐1β interleukin‐6, thus alleviating chronic inflammation improving conditions. conclusion, our comprehensive investigation highlights as key mediator dynamics modulation Targeting presents promising therapeutic strategy slow Tregs‐mediated positioning it novel target GC treatment.

Язык: Английский

---

Genetic and Epigenetic Characteristics in Isolated Pancreatic Metastases of Clear-Cell Renal Cell Carcinoma

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(22), С. 16292 - 16292

Опубликована: Ноя. 14, 2023

Isolated pancreatic metastases of renal cell carcinoma (IsPMRCC) are a rare manifestation metastatic, clear-cell (RCC) in which distant occur exclusively the pancreas. In addition to main symptom isolated occurrence metastases, entity surprises with additional clinical peculiarities: (a) unusually long interval about 9 years between primary RCC and onset metastases; (b) multiple occurring 36% cases; (c) favourable treatment outcomes 75% 5-year survival rate; (d) volume growth-rate dependent risk factors generally accepted be relevant for overall metastatic surgery insignificant isPMRCC. The genetic epigenetic causes exclusive involvement have not yet been investigated currently unknown. Conversely, according few available data literature, following peculiarities can already identified as cause protracted course: 1. high stability tumour clones both 2. low frequency copy number variants associated aggressiveness, such 9p, 14q 4q loss; 3. chromatin-modifying genes, decreased rate PAB1 (3%) an increased PBRM1 (77%) defects seen, profile course; 4. incidence KDM5C mutations, which, common alterations, is also outcome; 5. angiogenetic biomarkers tissue, while inflammatory decreased, explains good response TKI therapy lack sensitivity IT.

Язык: Английский

---

Effect of Bairui Granule on Inflammatory Mediators in Induced Sputum, Leukotriene C4, and EOS in Peripheral Blood of Children with Cough Variant Asthma

Computational and Mathematical Methods in Medicine, Год журнала: 2022, Номер 2022, С. 1 - 7

Опубликована: Июнь 8, 2022

Objective. To study the effect of Hanchuan Zupa granule combined with conventional western medicine in treatment children bronchial asthma. Methods. 98 cases Fengrun District People’s Hospital Tangshan City from June 2018 to February 2021 were selected. The control group was given oxygen therapy, antibiotics, and aerosol inhalation quick acting β 2 receptor agonist, glucocorticoid, other treatment, while observation treated Bairui on basis group. course two groups 1 week. Results. After levels sputum IL-4, IL-17, neu, ECP decreased, lower than ( P < 0.05 ). EOS, CXCR4, LTB4, SDF-1 peripheral blood those P < 0.05 daytime cough, night TCM syndrome scores P < 0.05 Conclusion. asthma, curative is worthy affirmation, can effectively improve cough symptoms, reduce CXCR, levels, inhibit airway inflammation, has good clinical application value.

Язык: Английский

---

Exosomes in Cancer Diagnosis and Therapy

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(17), С. 9930 - 9930

Опубликована: Сен. 1, 2022

Cancer affects millions of people worldwide every year [...].

Язык: Английский

---

In silico study of Actinium-225 (225AC) labelled pentixafor targeting CXCR4 and genetic dependency for breast cancer therapy

AIP conference proceedings, Год журнала: 2024, Номер 2967, С. 210005 - 210005

Опубликована: Янв. 1, 2024

The development of breast cancer treatment methods is currently growing rapidly with the emergence era targeted therapy. Various by targeting certain receptors that are specific to cells continue be developed, one which utilising radioisotope Actinium-225 (225Ac). As an alpha particle-emitting isotope, 225Ac known have enormous potential for One target receptor C-X-C chemokine type 4 (CXCR4), a small molecule chemoattractive cytokine regulates many cellular functions associated tumour dissemination and prognosis, including cancer. This study aimed assess suitability 225Ac-Pentixafor determining expression CXCR4 in several cell lines, optimised structure calculating binding labelled pentixafor, most advanced high-affinity ligand CXCR4. In this study, genetic dependency on lines was determined using Depmap R-Packages, density functional theory (DFT) method triple zeta (TZP) basis set running Orca software, docking carried out Autodock 4. According findings silico highly expressed blood cells, lymphocytes, plasma cells. solid tumours such as cancer, it transcript per million (TPM) based 22Q2 line DU4475 (6.833). Several often used research also high expressions, MCF7 (5.462) MDA-MB-361 (5.562). Additionally, total energy -24,597 kcal.mol−1, whereas estimated free -11.72 kcal.mol−1. value indicates stable, favourable. These important implications use therapy can vitro studies.

Язык: Английский

---