Pharmaceutics,
Год журнала:
2023,
Номер
15(5), С. 1514 - 1514
Опубликована: Май 17, 2023
At
present,
colorectal
cancer
(CRC)
is
the
second
deadliest
type
of
cancer,
partly
because
a
high
percentage
cases
are
diagnosed
at
advanced
stages
when
tumors
have
already
metastasized.
Thus,
there
an
urgent
need
to
develop
novel
diagnostic
systems
that
allow
early
detection
as
well
new
therapeutic
more
specific
than
those
currently
available.
In
this
context,
nanotechnology
plays
very
important
role
in
development
targeted
platforms.
recent
decades,
many
types
nanomaterials
with
advantageous
properties
been
used
for
nano-oncology
applications
and
loaded
different
agents,
capable
recognizing
tumor
cells
or
biomarkers.
Indeed,
among
most
widely
monoclonal
antibodies,
administration
them
approved
by
main
drug
regulatory
agencies
treatment
several
including
CRC.
way,
review
comprehensively
discusses
drawbacks
conventional
screening
technologies
CRC,
it
presents
advances
application
antibody-loaded
nanoplatforms
CRC
detection,
therapy
theranostics
applications.
In
recent
years,
the
incidence
of
gastrointestinal
cancers
is
increasing,
particularly
in
younger
population.
Effective
treatment
crucial
for
improving
patients'
survival
outcomes.
Programmed
cell
death,
regulated
by
various
genes,
plays
a
fundamental
role
growth
and
development
organisms.
It
also
critical
maintaining
tissue
organ
homeostasis
takes
part
multiple
pathological
processes.
addition
to
apoptosis,
there
are
other
types
programmed
such
as
ferroptosis,
necroptosis,
pyroptosis,
which
can
induce
severe
inflammatory
responses.
Notably,
besides
pyroptosis
contribute
occurrence
cancers.
This
review
aims
provide
comprehensive
summary
on
biological
roles
molecular
mechanisms
well
their
regulators
hope
open
up
new
paths
tumor
targeted
therapy
near
future.
Pharmaceutics,
Год журнала:
2023,
Номер
15(7), С. 1872 - 1872
Опубликована: Июль 3, 2023
With
the
predicted
rise
in
incidence
of
cancer,
there
is
an
ever-growing
need
for
new
cancer
treatment
strategies.
Recently,
magnetic
nanoparticles
have
stood
out
as
promising
nanostructures
imaging
and
drug
delivery
systems
they
possess
unique
properties.
Moreover,
nanomaterials
functionalized
with
other
compounds
can
lead
to
multicomponent
innovative
structures
synergetic
performance.
The
incorporation
chemotherapeutic
drugs
or
RNA
represents
a
alternative
that
increase
efficiency
reduce
side
effects
anticancer
therapy.
This
review
presents
critical
overview
recent
literature
concerning
advancements
field
used
delivery,
focus
on
their
classification,
characteristics,
synthesis
functionalization
methods,
limitations,
examples
incorporating
chemotherapeutics
RNA.
CNS Neuroscience & Therapeutics,
Год журнала:
2024,
Номер
30(5)
Опубликована: Май 1, 2024
Abstract
Gliomas
are
the
most
common
primary
tumors
of
central
nervous
system,
with
glioblastoma
multiforme
(GBM)
having
highest
incidence,
and
their
therapeutic
efficacy
depends
primarily
on
extent
surgical
resection
postoperative
chemotherapy.
The
role
intracranial
blood–brain
barrier
occurrence
drug‐resistant
gene
O6‐methylguanine‐DNA
methyltransferase
have
greatly
limited
chemotherapeutic
agents
in
patients
GBM
made
it
difficult
to
achieve
expected
clinical
response.
In
recent
years,
rapid
development
nanotechnology
has
brought
new
hope
for
treatment
tumors.
Nanoparticles
(NPs)
shown
great
potential
tumor
therapy
due
unique
properties
such
as
light,
heat,
electromagnetic
effects,
passive
targeting.
Furthermore,
NPs
can
effectively
load
drugs,
significantly
reduce
side
effects
improve
efficacy,
showing
chemotherapy
glioma.
this
article,
we
reviewed
mechanisms
glioma
drug
resistance,
physicochemical
NPs,
advances
resistance.
We
aimed
provide
perspectives
Bioengineering & Translational Medicine,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 26, 2025
Abstract
Gastrointestinal
cancers,
a
major
global
cause
of
cancer‐related
mortality
and
disease
burden,
are
heterogeneous
group
malignant
aliments
involving
different
organs
the
digestive
system.
The
late
clinical
diagnosis,
genomic
tumor
heterogeneity,
high
complexity
gastrointestinal
microenvironment,
along
with
increasing
treatment
resistance
have
been
recognized
as
main
contributing
factors
to
current
inadequacy
interventions
poor
prognosis
cancer
patients.
In
coming
years,
is
unfortunately
predicted
increase
due
absence
early
detection
effective
therapeutic
options.
Biomembrane‐coated
biomimetic
nanoparticles
(NPs)
recently
appointed
advanced
nanotechnological
tools
for
management
cancers.
These
comprise
not
only
cell‐mimicking
nanodevices
(the
pioneers
this
top‐down
coating
technology),
but
also
exosome
bacterial
mimetics.
Due
their
enhanced
bio‐interfacing
features,
biocompatibility,
immune
evasion,
specific
targetability
tumorous
tissues,
these
nanostructures
successfully
exploited
provide
safer,
effective,
targeted
applications.
This
review
highlights
latest
research
on
biomembrane‐coated
nanosystems
therapy
diagnosis
most
common
deadliest
subtypes
namely
colorectal
cancer,
gastric
liver
esophageal
pancreatic
cancer.
challenges
toward
translation
mentioned.
International Journal of Nanomedicine,
Год журнала:
2023,
Номер
Volume 18, С. 4143 - 4170
Опубликована: Июль 1, 2023
Abstract:
The
diagnosis
of
gastrointestinal
(GI)
diseases
currently
relies
primarily
on
invasive
procedures
like
digestive
endoscopy.
However,
these
can
cause
discomfort,
respiratory
issues,
and
bacterial
infections
in
patients,
both
during
after
the
examination.
In
recent
years,
nanomedicine
has
emerged
as
a
promising
field,
providing
significant
advancements
diagnostic
techniques.
Nanoprobes,
particular,
offer
distinct
advantages,
such
high
specificity
sensitivity
detecting
GI
diseases.
Integration
nanoprobes
with
advanced
imaging
techniques,
nuclear
magnetic
resonance,
optical
fluorescence
imaging,
tomography,
correlation
significantly
enhanced
detection
capabilities
for
tumors
inflammatory
bowel
disease
(IBD).
This
synergy
enables
early
precise
staging
disorders.
Among
nanoparticles
investigated
clinical
applications,
superparamagnetic
iron
oxide,
quantum
dots,
single
carbon
nanotubes,
nanocages
have
extensively
studied
utilized
agents.
review
aimed
to
provide
insights
into
potential
applications
modern
specific
focus
their
role
facilitating
range
disorders,
including
IBD
colorectal
cancer
(CRC).
Additionally,
we
discussed
challenges
associated
implementation
nanotechnology-based
diagnostics
explored
future
prospects
translation
this
field.
Keywords:
nano-diagnostics,
gastroenterology,
tumor,
Abstract
The
study
presents
a
transcriptomics‐based
liquid
biopsy
approach
for
early
recurrence
detection
in
locally
advanced
gastric
cancer
(LAGC).
Four
mRNA
biomarkers
(AGTR1,
DNER,
EPHA7,
and
SUSD5)
linked
to
are
identified
through
transcriptomic
data
analysis.
A
Risk
Stratification
Assessment
(RSA)
model
combining
these
with
clinical
features
showed
superior
predictive
accuracy
postoperative
recurrence,
AUCs
of
0.919
0.935
surgical
validation
cohorts,
respectively.
Functional
studies
using
human
cell
lines
AGS
HGC‐27
demonstrated
that
silencing
the
panel
genes
impaired
migration,
invasion,
proliferation.
In
vivo
experiments
further
reduced
tumor
growth,
metastasis,
lymphangiogenesis
mice,
possibly
mediated
by
cAMP
signaling
pathway.
This
non‐invasive
offers
significant
potential
enhancing
enabling
personalized
treatment
strategies,
thereby
improving
patient
outcomes
management
LAGC.
Journal of Translational Medicine,
Год журнала:
2024,
Номер
22(1)
Опубликована: Окт. 27, 2024
Gastrointestinal
tumors
are
the
main
causes
of
death
among
patients.
These
mainly
diagnosed
in
advanced
stages
and
their
response
to
therapy
is
unfavorable.
In
spite
development
conventional
therapeutics
including
surgery,
chemotherapy,
radiotherapy
immunotherapy,
treatment
these
still
challenging.
As
a
result,
new
based
on
(nano)biotechnology
have
been
introduced.
Hydrogels
polymeric
3D
networks
capable
absorbing
water
swell
with
favorable
biocompatibility.
application
hydrogels
different
human
diseases,
wide
cancer
has
improved
because
potential
drug
gene
delivery,
boosting
chemotherapy
immunotherapy
as
well
vaccines.
The
current
review
focuses
role
gastrointestinal
tumors.
provide
delivery
drugs
(both
natural
or
synthetic
compounds
co-delivery)
along
delivery.
Along
stimulate
phototherapy
(photothermal
photodynamic
therapy)
suppression
Besides,
ability
for
induction
immune-related
cells
such
dendritic
can
boost
immunotherapy.
For
more
specific
therapy,
stimuli-responsive
types
thermo-
pH-sensitive
self-healing
site
Moreover,
promising
diagnosis,
circulating
tumor
cell
isolation
detection
biomarkers
tumors,
highlighting
importance
clinic.
Hence,
diagnostic
therapeutic
tools
gastrointestimal
