Unravelling the role of intratumoral bacteria in digestive system cancers: current insights and future perspectives DOI Creative Commons
Weiqin Lu,

Aihemaitijiang Aihaiti,

Paziliya Abudukeranmu

et al.

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: June 7, 2024

Recently, research on the human microbiome, especially concerning bacteria within digestive system, has substantially advanced. This exploration unveiled a complex interplay between microbiota and health, particularly in context of disease. Evidence suggests that gut microbiome plays vital roles digestion, immunity synthesis vitamins neurotransmitters, highlighting its significance maintaining overall health. Conversely, disruptions these microbial communities, termed dysbiosis, have been linked to pathogenesis various diseases, including system cancers. These can influence cancer progression through mechanisms such as DNA damage, modulation tumour microenvironment, effects host's immune response. Changes composition function tumours also impact inflammation, response therapy effectiveness. findings offer promising avenues for clinical application intratumoral treatment, potential use markers early detection, prognostication development microbiome-targeted therapies enhance treatment outcomes. review aims provide comprehensive overview pivotal played by Additionally, we delve into specific contributions development, elucidating implications. Ultimately, this underscores intricate cancers, underscoring role transforming diagnostic, prognostic therapeutic paradigms

Language: Английский

Ferroptosis, Necroptosis, and Pyroptosis in Gastrointestinal Cancers: The Chief Culprits of Tumor Progression and Drug Resistance DOI Creative Commons
Xudong Zhu, Shenglong Li

Advanced Science, Journal Year: 2023, Volume and Issue: 10(26)

Published: July 12, 2023

In recent years, the incidence of gastrointestinal cancers is increasing, particularly in younger population. Effective treatment crucial for improving patients' survival outcomes. Programmed cell death, regulated by various genes, plays a fundamental role growth and development organisms. It also critical maintaining tissue organ homeostasis takes part multiple pathological processes. addition to apoptosis, there are other types programmed such as ferroptosis, necroptosis, pyroptosis, which can induce severe inflammatory responses. Notably, besides pyroptosis contribute occurrence cancers. This review aims provide comprehensive summary on biological roles molecular mechanisms well their regulators hope open up new paths tumor targeted therapy near future.

Language: Английский

Citations

47
Advancements in Metal and Metal Oxide Nanoparticles for Targeted Cancer Therapy and Imaging: Mechanisms, Applications, and Safety Concerns DOI Creative Commons
Jameema Sidhic, Aswathi Moothakoottil Kuttithodi, Aparna Prasad

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106622 - 106622

Published: Jan. 1, 2025

Language: Английский

Citations

2
Recent Advances in the Development of Drug Delivery Applications of Magnetic Nanomaterials DOI Creative Commons
Alexandra Pusta, Mihaela Tertiş, I. Crăciunescu

et al.

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(7), P. 1872 - 1872

Published: July 3, 2023

With the predicted rise in incidence of cancer, there is an ever-growing need for new cancer treatment strategies. Recently, magnetic nanoparticles have stood out as promising nanostructures imaging and drug delivery systems they possess unique properties. Moreover, nanomaterials functionalized with other compounds can lead to multicomponent innovative structures synergetic performance. The incorporation chemotherapeutic drugs or RNA represents a alternative that increase efficiency reduce side effects anticancer therapy. This review presents critical overview recent literature concerning advancements field used delivery, focus on their classification, characteristics, synthesis functionalization methods, limitations, examples incorporating chemotherapeutics RNA.

Language: Английский

Citations

38
Nanoparticles for efficient drug delivery and drug resistance in glioma: New perspectives DOI
Jiyuan Liu, Fan Yang, Jinqu Hu

et al.

CNS Neuroscience & Therapeutics, Journal Year: 2024, Volume and Issue: 30(5)

Published: May 1, 2024

Abstract Gliomas are the most common primary tumors of central nervous system, with glioblastoma multiforme (GBM) having highest incidence, and their therapeutic efficacy depends primarily on extent surgical resection postoperative chemotherapy. The role intracranial blood–brain barrier occurrence drug‐resistant gene O6‐methylguanine‐DNA methyltransferase have greatly limited chemotherapeutic agents in patients GBM made it difficult to achieve expected clinical response. In recent years, rapid development nanotechnology has brought new hope for treatment tumors. Nanoparticles (NPs) shown great potential tumor therapy due unique properties such as light, heat, electromagnetic effects, passive targeting. Furthermore, NPs can effectively load drugs, significantly reduce side effects improve efficacy, showing chemotherapy glioma. this article, we reviewed mechanisms glioma drug resistance, physicochemical NPs, advances resistance. We aimed provide perspectives

Language: Английский

Citations

12
Biomembrane‐coated nanosystems as next‐generation delivery systems for the treatment of gastrointestinal cancers DOI Creative Commons
Joana Lopes, Daniela Lopes, Mahzad Motallebi

et al.

Bioengineering & Translational Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 26, 2025

Abstract Gastrointestinal cancers, a major global cause of cancer‐related mortality and disease burden, are heterogeneous group malignant aliments involving different organs the digestive system. The late clinical diagnosis, genomic tumor heterogeneity, high complexity gastrointestinal microenvironment, along with increasing treatment resistance have been recognized as main contributing factors to current inadequacy interventions poor prognosis cancer patients. In coming years, is unfortunately predicted increase due absence early detection effective therapeutic options. Biomembrane‐coated biomimetic nanoparticles (NPs) recently appointed advanced nanotechnological tools for management cancers. These comprise not only cell‐mimicking nanodevices (the pioneers this top‐down coating technology), but also exosome bacterial mimetics. Due their enhanced bio‐interfacing features, biocompatibility, immune evasion, specific targetability tumorous tissues, these nanostructures successfully exploited provide safer, effective, targeted applications. This review highlights latest research on biomembrane‐coated nanosystems therapy diagnosis most common deadliest subtypes namely colorectal cancer, gastric liver esophageal pancreatic cancer. challenges toward translation mentioned.

Language: Английский

Citations

1
Nanomaterials in the diagnosis and treatment of gastrointestinal tumors: New clinical choices and treatment strategies DOI Creative Commons
Liping Chen,

Qingqing Li

Materials Today Bio, Journal Year: 2025, Volume and Issue: 32, P. 101782 - 101782

Published: April 19, 2025

Language: Английский

Citations

1
Application of Nanoparticles in the Diagnosis of Gastrointestinal Diseases: A Complete Future Perspective DOI Creative Commons

Ning-ning Yue,

Haoming Xu,

Jing Xu

et al.

International Journal of Nanomedicine, Journal Year: 2023, Volume and Issue: Volume 18, P. 4143 - 4170

Published: July 1, 2023

Abstract: The diagnosis of gastrointestinal (GI) diseases currently relies primarily on invasive procedures like digestive endoscopy. However, these can cause discomfort, respiratory issues, and bacterial infections in patients, both during after the examination. In recent years, nanomedicine has emerged as a promising field, providing significant advancements diagnostic techniques. Nanoprobes, particular, offer distinct advantages, such high specificity sensitivity detecting GI diseases. Integration nanoprobes with advanced imaging techniques, nuclear magnetic resonance, optical fluorescence imaging, tomography, correlation significantly enhanced detection capabilities for tumors inflammatory bowel disease (IBD). This synergy enables early precise staging disorders. Among nanoparticles investigated clinical applications, superparamagnetic iron oxide, quantum dots, single carbon nanotubes, nanocages have extensively studied utilized agents. review aimed to provide insights into potential applications modern specific focus their role facilitating range disorders, including IBD colorectal cancer (CRC). Additionally, we discussed challenges associated implementation nanotechnology-based diagnostics explored future prospects translation this field. Keywords: nano-diagnostics, gastroenterology, tumor,

Language: Английский

Citations

17
Transcriptomics‐Based Liquid Biopsy for Early Detection of Recurrence in Locally Advanced Gastric Cancer DOI Creative Commons
Pingan Ding, Jiaxiang Wu, Haotian Wu

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(47)

Published: Nov. 18, 2024

Abstract The study presents a transcriptomics‐based liquid biopsy approach for early recurrence detection in locally advanced gastric cancer (LAGC). Four mRNA biomarkers (AGTR1, DNER, EPHA7, and SUSD5) linked to are identified through transcriptomic data analysis. A Risk Stratification Assessment (RSA) model combining these with clinical features showed superior predictive accuracy postoperative recurrence, AUCs of 0.919 0.935 surgical validation cohorts, respectively. Functional studies using human cell lines AGS HGC‐27 demonstrated that silencing the panel genes impaired migration, invasion, proliferation. In vivo experiments further reduced tumor growth, metastasis, lymphangiogenesis mice, possibly mediated by cAMP signaling pathway. This non‐invasive offers significant potential enhancing enabling personalized treatment strategies, thereby improving patient outcomes management LAGC.

Language: Английский

Citations

5
Innovative theranostic hydrogels for targeted gastrointestinal cancer treatment DOI Creative Commons
Min Tang, Jia Song, Shuyi Zhang

et al.

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: Oct. 27, 2024

Gastrointestinal tumors are the main causes of death among patients. These mainly diagnosed in advanced stages and their response to therapy is unfavorable. In spite development conventional therapeutics including surgery, chemotherapy, radiotherapy immunotherapy, treatment these still challenging. As a result, new based on (nano)biotechnology have been introduced. Hydrogels polymeric 3D networks capable absorbing water swell with favorable biocompatibility. application hydrogels different human diseases, wide cancer has improved because potential drug gene delivery, boosting chemotherapy immunotherapy as well vaccines. The current review focuses role gastrointestinal tumors. provide delivery drugs (both natural or synthetic compounds co-delivery) along delivery. Along stimulate phototherapy (photothermal photodynamic therapy) suppression Besides, ability for induction immune-related cells such dendritic can boost immunotherapy. For more specific therapy, stimuli-responsive types thermo- pH-sensitive self-healing site Moreover, promising diagnosis, circulating tumor cell isolation detection biomarkers tumors, highlighting importance clinic. Hence, diagnostic therapeutic tools gastrointestimal

Language: Английский

Citations

4
Therapeutic Applications of Plant Virus Nanoparticles in Cancer Treatment and Nanomedicine DOI
Muhammad Majid, Muhammad Safdar Hussain,

Hamza Khaliq

et al.

Indus journal of bioscience research., Journal Year: 2025, Volume and Issue: 3(1), P. 429 - 437

Published: Jan. 20, 2025

Plant virus nanoparticles (VNPs) are inexpensive to produce, dependable, and reusable have emerged as a versatile promising platform in nanomedicine, particularly cancer therapy. These biogenic nanostructures possess unique physicochemical properties, including biocompatibility, biodegradability, structural uniformity, making them ideal candidates for targeted drug delivery. The ability of such encapsulate chemotherapeutic agents functionalize with tumor-specific ligands facilitates precise delivery cancerous tissues, minimizing off-target effects enhancing therapeutic efficacy. In addition, plant viral vectors (VLPs) an attractive option causing anti-tumor immunity because they undoubtedly secure, harmless, suitable mass manufacture pharmacological adaptation. This review delves into the molecular architecture nanoparticles, their functional modifications, mechanisms by which interact cells. Additionally, it highlights preclinical studies emerging clinical applications, addressing both opportunities challenges translating VNPs from bench bedside. By exploring anticancer potentials VNPs, this paper aims underscore role shaping future sustainable, plant-derived nanotechnology oncology.

Language: Английский

Citations

0