The role of glycolytic metabolic pathways in cardiovascular disease and potential therapeutic approaches

Basic Research in Cardiology, Год журнала: 2023, Номер 118(1)

Опубликована: Ноя. 8, 2023

Abstract Cardiovascular disease (CVD) is a major threat to human health, accounting for 46% of non-communicable deaths. Glycolysis conserved and rigorous biological process that breaks down glucose into pyruvate, its primary function provide the body with energy intermediate products needed life activities. The non-glycolytic actions enzymes associated glycolytic pathway have long been found be development CVD, typically exemplified by metabolic remodeling in heart failure, which condition exhibits rapid adaptive response hypoxic conditions, occurring early course failure. It mainly characterized decrease oxidative phosphorylation rise pathway, glycolysis considered hallmark remodeling. In addition this, main source cardiomyocytes during ischemia–reperfusion. Not only that, auxiliary pathways glycolysis, such as polyol hexosamine pentose phosphate are also closely related CVD. Therefore, targeting very attractive therapeutic intervention However, relationship between CVD complex, some preclinical studies confirmed does certain degree efficacy, but specific role has yet explored. This article aims summarize current knowledge regarding key (including hexokinase (HK), phosphoglucose isomerase (PGI), phosphofructokinase-1 (PFK1), aldolase (Aldolase), phosphoglycerate metatase (PGAM), enolase (ENO) pyruvate kinase (PKM) lactate dehydrogenase (LDH)) their cardiovascular diseases (e.g., myocardial infarction, atherosclerosis) possible emerging targets.

Язык: Английский

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LncRNA CCAT1 facilitates the progression of gastric cancer via PTBP1-mediated glycolysis enhancement

Journal of Experimental & Clinical Cancer Research, Год журнала: 2023, Номер 42(1)

Опубликована: Сен. 23, 2023

Gastric cancer (GC) is one of the most prevalent malignant tumors digestive system. As a hallmark cancer, energy-related metabolic reprogramming manipulated by multiple factors, including long non-coding RNAs (lncRNAs). Notably, lncRNA CCAT1 has been identified as crucial regulator in tumor progression. Nevertheless, precise molecular mechanisms underlying involvement GC remain unclear. Gain- and loss-of-function experiments were performed to evaluate roles tumorigenesis glycolysis GC. Bioinformatics analyses mechanistic experiments, such mass spectrometry (MS), RNA-pulldown, RNA immunoprecipitation (RIP), employed reveal potential interacting protein elucidate regulatory mechanism glycolysis. Moreover, nude mice xenograft assay was used effect on cells vivo. In this study, we that expression significantly elevated tissues plasma exosomes patients, well cell lines. Functional showed knockdown resulted substantial decrease proliferation, migration invasion both vitro vivo through decreasing glycolytic enzymes rate. Conversely, overexpression exhibited contrasting effects. Mechanistically, interacted with PTBP1 effectively maintained its stability inhibiting ubiquitin-mediated degradation process. critical splicing factor, facilitated transition from PKM1 PKM2, thereby augmenting activity ultimately fostering progression Our findings demonstrate plays significant role promoting migration, PTBP1/PKM2/glycolysis pathway, thus suggesting CCAT1's biomarker therapeutic target for

Язык: Английский

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NIR-II imaging-guided precise photodynamic therapy for augmenting tumor-starvation therapy by glucose metabolism reprogramming interference

Science Bulletin, Год журнала: 2024, Номер 69(9), С. 1263 - 1274

Опубликована: Фев. 9, 2024

Язык: Английский

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Exploring the mystery of tumor metabolism: Warburg effect and mitochondrial metabolism fighting side by side

Cellular Signalling, Год журнала: 2024, Номер 120, С. 111239 - 111239

Опубликована: Май 28, 2024

Язык: Английский

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Targeting tumor-intrinsic SLC16A3 to enhance anti-PD-1 efficacy via tumor immune microenvironment reprogramming

Cancer Letters, Год журнала: 2024, Номер 589, С. 216824 - 216824

Опубликована: Март 23, 2024

Immunotherapy, especially immune checkpoint inhibitors, has revolutionized clinical practice within the last decade. However, primary and secondary resistance to immunotherapy is common in patients with diverse types of cancer. It well-acknowledged that tumor cells can facilitate formation immunosuppressive microenvironments via metabolism reprogramming, lactic acid, metabolite glycolysis, a significant contributor. SLC16A3 (also named as MCT4) transporter mediating acid efflux. In this study, we investigated role glycolysis aimed improve effects Slc16a3 inhibition. Bioinformatical analysis revealed expression glycolysis-related genes correlated less CD8

Язык: Английский

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Comprehensive review of histone lactylation: Structure, function, and therapeutic targets

Biochemical Pharmacology, Год журнала: 2024, Номер 225, С. 116331 - 116331

Опубликована: Май 29, 2024

Язык: Английский

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The role of targeting glucose metabolism in chondrocytes in the pathogenesis and therapeutic mechanisms of osteoarthritis: a narrative review

Frontiers in Endocrinology, Год журнала: 2024, Номер 15

Опубликована: Март 6, 2024

Osteoarthritis (OA) is a common degenerative joint disease that can affect almost any joint, mainly resulting in dysfunction and pain. Worldwide, OA affects more than 240 million people one of the leading causes activity limitation adults. However, pathogenesis remains elusive, lack well-established clinical treatment strategies. Recently, energy metabolism alterations have provided new insights into OA. Accumulating evidence indicates glucose plays key role maintaining cartilage homeostasis. Disorders lead to chondrocyte hypertrophy extracellular matrix degradation, promote occurrence development This article systematically summarizes regulatory effects different enzymes factors related OA, as well mechanism potential various substances by affecting metabolism. provides theoretical basis for better understanding progression optimal prevention

Язык: Английский

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Metabolism-regulating non-coding RNAs in breast cancer: roles, mechanisms and clinical applications

Journal of Biomedical Science, Год журнала: 2024, Номер 31(1)

Опубликована: Фев. 26, 2024

Abstract Breast cancer is one of the most common malignancies that pose a serious threat to women's health. Reprogramming energy metabolism major feature malignant transformation breast cancer. Compared normal cells, tumor cells reprogram metabolic processes more efficiently, converting nutrient supplies into glucose, amino acid and lipid required for proliferation progression. Non-coding RNAs(ncRNAs) are class functional RNA molecules not translated proteins but regulate expression target genes. NcRNAs have been demonstrated be involved in various aspects metabolism, including glycolysis, glutaminolysis, fatty synthesis. This review focuses on regulatory mechanisms clinical applications metabolism-regulating ncRNAs We summarize vital roles played by endocrine therapy, targeted chemotherapy, immunotherapy, radiotherapy resistance cancer, as well their potential therapeutic targets biomarkers. Difficulties perspectives current non-coding strategies discussed.

Язык: Английский

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Trophoblast-derived miR-410-5p induces M2 macrophage polarization and mediates immunotolerance at the fetal-maternal interface by targeting the STAT1 signaling pathway

Journal of Translational Medicine, Год журнала: 2024, Номер 22(1)

Опубликована: Янв. 4, 2024

Abstract Background Macrophages phenotypic deviation and immune imbalance play vital roles in pregnancy-associated diseases such as spontaneous miscarriage. Trophoblasts regulate changes macrophages, however, their underlying mechanism during pregnancy remains unclear. Therefore, this study aimed to elucidate the potential function of trophoblast-derived miRNAs (miR-410-5p) macrophage polarization pregnancy. Methods Patient decidual tissue samples abortion group normal (those who had induced for non-medical reasons) were collected at Reproductive Medicine Center Renmin Hospital Wuhan University from April December 2021. Furthermore, placental villi decidua patients experienced a miscarriage pregnant women validation subsequent experiments Shenzhen Zhongshan Obstetrics & Gynecology (formerly Urology Hospital), March 2021 September 2022. As an animal model, 36 female mice randomly divided into six groups follows: naive-control, lipopolysaccharide-model, agomir-negative control prevention, agomir-410-5p treatment, treatment groups. We analyzed miR-410-5p expression plasma samples; supplemented evaluate embryonic absorption vivo. The main source maternal–fetal interface was analyzed, possible target gene, signal transducer activator transcription (STAT) 1, predicted. effect STAT1 regulation on phenotype, oxidative metabolism, mitochondrial membrane vitro. Results MiR-410-5p levels lower compared with group, could predict abortion. Prophylactic supplementation reduced lipopolysaccharide-mediated downregulated pro-inflammatory phenotype. mainly distributed villi, trophoblasts secreted exosomes-miR-410-5p interface. After macrophages captured exosomes, cells shifted tolerance gene miR-410-5p. bound mRNA, inhibited protein. can drive mature competitive silencing avoid disorders. Conclusion promotes M2 by inhibiting STAT1, thus ensuring healthy These findings are great significance diagnosing preventing miscarriage, providing new perspective further research field.

Язык: Английский

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The role of lncRNA NEAT1 in human cancer chemoresistance

Cancer Cell International, Год журнала: 2024, Номер 24(1)

Опубликована: Июль 5, 2024

Abstract Chemotherapy is currently one of the most effective methods in clinical cancer treatment. However, chemotherapy resistance an important reason for poor efficacy and prognosis, which has become urgent problem to be solved field chemotherapy. Therefore, it very deeply study analyze mechanism its regulatory factors. Long non-coding RNA nuclear paraspeckle assembly transcript 1 (LncRNA NEAT1) been shown closely associated with cancer. NEAT1 induces cell chemotherapeutic drugs by regulating apoptosis, cycle, drug transport metabolism, DNA damage repair, EMT, autophagy, stem characteristics, metabolic reprogramming. This indicates that may target overcome expected a potential biomarker predict effect article summarizes expression characteristics different cancers, discusses role related molecular mechanisms, aiming clarify as new feasibility sensitizers, view providing therapeutic direction overcoming dilemma future.

Язык: Английский

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