International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 136596 - 136596
Опубликована: Окт. 1, 2024
Язык: Английский
International Journal of Pharmaceutics, Год журнала: 2025, Номер 670, С. 125186 - 125186
Опубликована: Янв. 8, 2025
The blood-brain barrier (BBB) plays a vital role in protecting the central nervous system (CNS) by preventing entry of harmful pathogens from bloodstream. However, this also presents significant obstacle when it comes to delivering drugs for treatment neurodegenerative diseases and brain cancer. Recent breakthroughs nanotechnology have paved way creation wide range nanoparticles (NPs) that can serve as carriers diagnosis therapy. Regarding their promising properties, organic NPs potential be used effective drug delivery across BBB based on recent advancements. These remarkable ability penetrate using various mechanisms. This review offers comprehensive examination intricate structure distinct properties BBB, emphasizing its crucial function preserving balance regulating transport ions molecules. disruption conditions such stroke, Alzheimer's disease, Parkinson's disease highlights importance developing creative approaches drugs. Through encapsulation therapeutic molecules precise targeting processes vasculature, NP formulations present hopeful strategy improve BBB. We explore changes pathological investigate factors affect successful into brain. In addition, we most systems associated with shown positive results treating ischemic disorders. opens up new possibilities nanotechnology-based therapies cerebral diseases.
Язык: Английский
Процитировано
7
Archives of Dermatological Research, Год журнала: 2025, Номер 317(1)
Опубликована: Янв. 31, 2025
Язык: Английский
Процитировано
5
European Journal of Medicinal Chemistry, Год журнала: 2025, Номер 287, С. 117357 - 117357
Опубликована: Фев. 5, 2025
Язык: Английский
Процитировано
5
Critical Reviews in Analytical Chemistry, Год журнала: 2024, Номер unknown, С. 1 - 25
Опубликована: Сен. 17, 2024
This comprehensive review delves into the advancements and challenges in biosensing, with a strong emphasis on transformative potential of CRISPR technology for early rapid detection infectious diseases. It underscores versatility CRISPR/Cas systems, highlighting their ability to detect both nucleic acids non-nucleic acid targets, seamless integration isothermal amplification techniques. The provides thorough examination latest developments CRISPR-based biosensors, detailing unique properties such as high specificity programmability, which make them particularly effective detecting disease-associated acids. While focuses due its critical role diagnosing diseases, it also explores broader applications thereby acknowledging technology's potential. Additionally, identifies existing challenges, need improved signal real-world applicability, offers future perspectives aimed at overcoming these hurdles. ultimate goal is advance development highly sensitive specific biosensors that can be used widely improving human health, point-of-care settings resource-limited environments.
Язык: Английский
Процитировано
12
Frontiers in Cell and Developmental Biology, Год журнала: 2025, Номер 13
Опубликована: Фев. 3, 2025
Multiple sclerosis (MS), a chronic autoimmune disorder of the central nervous system (CNS), is characterized by inflammation, demyelination, and neurodegeneration, leading to diverse clinical manifestations such as fatigue, sensory impairment, cognitive dysfunction. Current pharmacological treatments primarily target immune modulation but fail arrest disease progression or entirely reverse CNS damage. Mesenchymal stem cell (MSC) therapy offers promising alternative, leveraging its immunomodulatory, neuroprotective, regenerative capabilities. This review provides an in-depth analysis MSC mechanisms action, including regulation, promotion remyelination, neuroregeneration. It examines preclinical studies trials evaluating efficacy, safety, limitations in various MS phenotypes. Special attention given challenges delivery routes, dosing regimens, integrating MSCs with conventional therapies. By highlighting advancements ongoing challenges, this underscores potential revolutionize treatment, paving way for personalized combinatory therapeutic approaches.
Язык: Английский
Процитировано
1
Frontiers in Neurology, Год журнала: 2025, Номер 16
Опубликована: Фев. 5, 2025
Traumatic brain injury (TBI) is a complex condition involving mechanisms that lead to dysfunction and nerve damage, resulting in significant morbidity mortality globally. Affecting ~50 million people annually, TBI's impact includes high death rate, exceeding of heart disease cancer. Complications arising from TBI encompass concussion, cerebral hemorrhage, tumors, encephalitis, delayed apoptosis, necrosis. Current treatment methods, such as pharmacotherapy with dihydropyridines, high-pressure oxygen therapy, behavioral non-invasive stimulation, have shown limited efficacy. A comprehensive understanding vascular components essential for developing new treatments improve blood vessel-related damage. Recently, mesenchymal stem cells (MSCs) promising results repairing mitigating Studies indicate MSCs can promote neurogenesis angiogenesis through various mechanisms, including releasing bioactive molecules extracellular vesicles (EVs), which help reduce neuroinflammation. In research, the distinctive characteristics positioned them highly desirable cell sources. Extensive investigations been conducted on regulatory properties their manipulation, tagging, transportation techniques brain-related applications. This review explores progress prospects MSC therapy TBI, focusing action, therapeutic benefits, challenges potential limitations using treating neurological disorders.
Язык: Английский
Процитировано
1
Life Sciences, Год журнала: 2024, Номер unknown, С. 123120 - 123120
Опубликована: Окт. 1, 2024
Язык: Английский
Процитировано
7
Frontiers in Cell and Developmental Biology, Год журнала: 2024, Номер 12
Опубликована: Дек. 12, 2024
Mortality and morbidity from cardiovascular diseases are common worldwide. In order to improve survival quality of life for this patient population, extensive efforts being made establish effective therapeutic modalities. New treatment options needed, it seems. addition treating diseases, cell therapy is one the most promising medical platforms. One approaches in area stem therapy. biology, multipotent cells pluripotent divided into two types. There evidence that could be used as a approach based on multiple lines evidence. The effectiveness therapies humans has been studied several clinical trials. spite challenges associated with therapy, appears resolving them may lead disease patients. This an approach. By mounting these biological scaffolds, their effect can enhanced.
Язык: Английский
Процитировано
7
Frontiers in Microbiology, Год журнала: 2024, Номер 15
Опубликована: Ноя. 29, 2024
The most prevalent and harmful injuries are burns, which still a major global health problem. Burn can cause issues because they boost the inflammatory metabolic response, organ malfunction systemic failure. On other hand, burn wound infection creates an environment that is conducive to growth of bacteria might put patient at risk for sepsis. In addition, scarring unavoidable, this results in patients having functional cosmetic issues. Wound healing amazing phenomenon with complex mechanism deals different types cells biomolecules. Cell therapy using stem one challenging treatment methods accelerates wounds. Since 2000, use mesenchymal (MSCs) regenerative medicine has increased. They be extracted from various tissues, such as bone marrow, fat, umbilical cord, amniotic membrane. According studies, cell wounds increases angiogenesis, anti-inflammatory properties, slows progression fibrosis, excellent ability differentiate regenerate damaged tissue. Figuring out main preclinical clinical problems stop people MSCs then suggesting right ways improve could help show benefits move cell-based forward. This review's objective was assess therapy's contribution promotion healing.
Язык: Английский
Процитировано
6
Journal of Materials Science Materials in Electronics, Год журнала: 2024, Номер 35(35)
Опубликована: Дек. 1, 2024
Язык: Английский
Процитировано
6