Small-Molecule Fluorescent Probes for Binding- and Activity-Based Sensing of Redox-Active Biological Metals

Chemical Reviews, Год журнала: 2024, Номер 124(9), С. 5846 - 5929

Опубликована: Апрель 24, 2024

Although transition metals constitute less than 0.1% of the total mass within a human body, they have substantial impact on fundamental biological processes across all kingdoms life. Indeed, these nutrients play crucial roles in physiological functions enzymes, with redox properties many being essential to their activity. At same time, imbalances metal pools can be detrimental health. Modern analytical techniques are helping illuminate workings homeostasis at molecular and atomic level, spatial localization real implications dysregulation disease pathogenesis. Fluorescence microscopy has proven one most promising non-invasive methods for studying samples. The accuracy sensitivity bioimaging experiments predominantly determined by fluorescent metal-responsive sensor, highlighting importance rational probe design such measurements. This review covers activity- binding-based sensors that been applied cellular studies. We focus redox-active metals: iron, copper, manganese, cobalt, chromium, nickel. aim encourage further targeted efforts developing innovative approaches understanding chemistry metals.

Язык: Английский

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Fluorescent Sensors for Detecting and Imaging Metal Ions in Biological Systems: Recent Advances and Future Perspectives

Chemosensors, Год журнала: 2023, Номер 11(4), С. 226 - 226

Опубликована: Апрель 6, 2023

Metal ions play a crucial role in many biochemical processes, and when state of scarcity or surplus, they can lead to various diseases. Therefore, the development selective, sensitive, cost-effective, fast-responding sensor detect metal is critical for vitro medical diagnostics. In recent years, fluorescent sensors have been extensively investigated as potent kits effective assessment living systems due their high sensitivity, selectivity, ability perform real-time, non-invasive monitoring, versatility. This review an overview advances detection imaging biosystems from 2018 date. Specifically, we discuss application detecting essential non-essential diagnostics, cell imaging, vivo imaging. Finally, summarize remaining challenges offer future outlook on above topics.

Язык: Английский

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A review on dual detection of Cu2+ and Ni2+ ions by using single fluorometric and colorimetric organic molecular probes

Journal of Molecular Structure, Год журнала: 2023, Номер 1278, С. 134949 - 134949

Опубликована: Янв. 11, 2023

Язык: Английский

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Flexible carbon fiber cloth supports decorated with cerium metal- organic frameworks and multi-walled carbon nanotubes for simultaneous on-site detection of Cd2+ and Pb2+ in food and water samples

Food Chemistry, Год журнала: 2023, Номер 418, С. 135869 - 135869

Опубликована: Март 11, 2023

Язык: Английский

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Fluorescent probes based on cellulose for sensitive detection of Fe3+ and its applications

Industrial Crops and Products, Год журнала: 2024, Номер 210, С. 118178 - 118178

Опубликована: Фев. 9, 2024

Язык: Английский

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Two AIE-Ligand-Based 2-D Luminescent Metal–Organic Frameworks as Fe³⁺ Sensors

Inorganic Chemistry, Год журнала: 2024, Номер 63(18), С. 8342 - 8350

Опубликована: Апрель 19, 2024

The design and synthesis of high-performance sensors are very important but remain great challenges. In this work, a new aggregation-induced-emission (AIE) molecule 4,4′-(((9H-fluoren-9-ylidene)methylene)bis(4,1-phenylene))dipyridine (L) was successfully synthesized first developed as functional ligand to construct two isomorphic metal–organic frameworks (MOFs) [M(L)(OBBA)]n [M2+ = Cd2+ (1), Co2+ (2); H2OBBA 4,4′-oxybisbenzoic acid]. They adopt [M2(COO)4] flywheel clusters, OBBA2– bridges, terminal L ligands building units form 2-D networks with Lewis base active cites (uncoordinated pyridyl N). Both 1 2 exhibit excellent water, pH, thermal stabilities extremely efficient Fe3+ sensing abilities in the water environment. quenching constants detection limits reach best levels reported so far. mechanism toward is studied depth, difference their performance also explained.

Язык: Английский

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A Carbamoyl Oxime-Based Highly Specific Fluorescent Chemodosimeter for Monitoring Labile Fe²⁺ in Food and Living Organisms

Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер 72(23), С. 13341 - 13347

Опубликована: Июнь 3, 2024

Iron is an essential element in the composition of living organisms and plays a crucial role wide range biological activities. The human body primarily obtains iron through consumption food. Therefore, it vital for health to maintain homeostasis. reducing character cellular microenvironment enables Fe2+ occupy dominant position within cell. Hence, there urgent need simple sensitive tool that can detect large amount organisms. In this work, highly specific fluorescent chemodosimeter NPCO ("NP" represents naphthalimide fluorophore, "CO" carbamoyl oxime structure) detection with excellent sensitivity (LOD = 82 nM) was constructed by incorporating novel structure as recognition group. be effectively employed food samples, cells, zebrafish. Furthermore, using soybean sprouts model plant, application expanded plants. could used assay detecting expected important aid exploring mechanism regulation.

Язык: Английский

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A novel fluorescent probe based on phenothiazine for recognition of Ni2+ and ClO− and its applications

Inorganic Chemistry Communications, Год журнала: 2024, Номер 162, С. 112079 - 112079

Опубликована: Янв. 24, 2024

Язык: Английский

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Mitochondrial targeting fluorescent probe for specific detection of nickel ions and biological imaging

Journal of Photochemistry and Photobiology A Chemistry, Год журнала: 2023, Номер 444, С. 114912 - 114912

Опубликована: Июнь 21, 2023

Язык: Английский

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Two-photon fluorescent chemosensors based on the GFP-chromophore for the detection of Zn2+ in biological samples – From design to application

Sensors and Actuators B Chemical, Год журнала: 2023, Номер 398, С. 134753 - 134753

Опубликована: Окт. 11, 2023

A library of twelve novel fluorescent GFP chromophore based chemosensors (GFZnPs) was prepared for the detection Zn2+ in biological samples with two-photon microscopy. The presented compounds are hybrids chelator 8-aminoquinoline motif and chromophore, exploiting enhancing properties natural chromophore. In probes, quenching rotation around benzylidene carbon is conditionally blocked upon binding, resulting a response to ion. GFZnPs have an efficient simple synthesis making them one most easily accessible sensors. We present comprehensive spectroscopical characterization probe family highlighting their bright emission (ε×Φ > 200) at λem∼520 nm excitation by λex∼450 light. sensors feature high selectivity affinity nanomolar range, excellent water solubility, usability wide pH-range (pH 6). relationship between structure studied rationalized theoretical considerations. 2P-action cross section probes reaches δ×Φcomp 5 GM λex, 2P=900 nm, increase up 200-fold, which makes best Zn2+. applicability selected demonstrated epifluorescent 2 P microscopy on cultured cells brain slices. This work expands toolbox zinc valuable new family.

Язык: Английский

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