Carbon-Decorated Fe3O4 Nanocomposites as Enhanced Enzyme Mimics for Colorimetric Determination of H2O2 and Glucose DOI
Bin Li,

Heng Liu,

Xianrong Xing

и другие.

ACS Applied Nano Materials, Год журнала: 2024, Номер unknown

Опубликована: Авг. 30, 2024

The development of sensitive and accurate glucose biosensors is significant in diabetic patient monitoring. Here, we synthesize carbon-decorated Fe3O4 nanotubes (Fe3O4@C NTs) using a rational designed template method. Through catalytic oxidation typical colorimetric reaction, the prepared Fe3O4@C NTs showed significantly better peroxidase-like oxidase-like performances than other similar Fe3O4-based nanomaterials. Moreover, optimal pH, temperature, concentration for were 4.0, 60 °C, 40 μg/mL, respectively. We additionally investigated steady-state kinetics NTs, their catalyzed reactions found to follow Michaelis–Menten model. Based on activity they employed label-free, rapid, selective, highly detection H2O2 glucose, demonstrating potential application determination.

Язык: Английский

Temperature-resilient and sustainable Mn-MOF oxidase-like nanozyme (UoZ-4) for total antioxidant capacity sensing in some citrus fruits: Breaking the temperature barrier DOI
Sameera Sh. Mohammed Ameen, Khalid M. Omer

Food Chemistry, Год журнала: 2024, Номер 448, С. 139170 - 139170

Опубликована: Март 29, 2024

Язык: Английский

Процитировано

54

Multi-signal sensor array based on a fluorescent nanozyme for broad-spectrum screening of pesticides DOI
Donghui Song, Tian Tian, Le Wang

и другие.

Chemical Engineering Journal, Год журнала: 2024, Номер 482, С. 148784 - 148784

Опубликована: Янв. 17, 2024

Язык: Английский

Процитировано

34

Supercritical CO2 utilization for solubility measurement of Tramadol hydrochloride drug: Assessment of cubic and non-cubic EoSs DOI
Gholamhossein Sodeifian, Hamidreza Bagheri, Fariba Razmimanesh

и другие.

The Journal of Supercritical Fluids, Год журнала: 2024, Номер 206, С. 106185 - 106185

Опубликована: Янв. 9, 2024

Язык: Английский

Процитировано

21

Fluorescent Fingerprint Identification of Protein Structural Changes and Disease-Specific Amyloid Beta Aggregates Based on a Single-Nanozyme Sensor Array DOI
Xiaohai Yang, Min Zhang, Na Lü

и другие.

Analytical Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Фев. 25, 2025

The misfolding of amyloid β (Aβ) peptides into an aggregation state is a central hallmark the onset Alzheimer's disease (AD). However, conventional methods are mainly focused on detecting specific Aβ peptide, which makes it difficult to recognize multiple analytes with different topological features and unfolded states at same time. Here, we propose simple universal sensing strategy construct fluorescence sensor array by using single-nanozyme probe combined three fluorescent substrates as recognition units protein structural changes identify between assemblies. In this system, fingerprint-like patterns produced from nonspecific interactions proteins units. As result, can accurately 13 kinds their mixtures ratios. Moreover, discriminate against diverse conformational forms. Most importantly, successfully distinguishes species, even in artificial cerebrospinal fluid samples human serum samples. This work provides attractive reliable for predicting pathologically relevant clinical diagnosis AD.

Язык: Английский

Процитировано

4

A graphene oxide/polyaniline nanocomposite biosensor: synthesis, characterization, and electrochemical detection of bilirubin DOI Creative Commons

N. Ahmed,

Chou‐Yi Hsu,

Zaid H. Mahmoud

и другие.

RSC Advances, Год журнала: 2023, Номер 13(51), С. 36280 - 36292

Опубликована: Янв. 1, 2023

The level of free bilirubin is a considerable index for the characterization jaundice-related diseases. Herein, biosensor was fabricated via immobilization oxidase (BOx) on graphene oxide (GO) and polyaniline (PANI) that were electrochemically co-precipitated indium tin (ITO) conductive glass. structural enzyme electrode characterized by FTIR, XRD, Raman spectroscopy, while spectral thermal properties investigated UV-vis thermogravimetric analysis (TGA). Owing to activity BOx/GO@PANI/ITO biosensor, it could detect with good selectivity sensitivity in low response time. electrochemical studied using impedance spectroscopy (EIS) cyclic voltammetry (CV). At polarization potential 0.2 V vs. Ag/AgCl, sensor illustrated only 2 s at 30 °C pH 7.5. LOD LOQ calculated found be 0.15 nM 2.8 nM, respectively. signal showed linear concentration range 0.01-250 μM. 5 °C, demonstrated half-time 120 days, through which utilized 100 times this temperature conditions. By common colorimetric method, data levels serum determination coefficient (R2) 0.97.

Язык: Английский

Процитировано

36

Recent trends in nanozyme research and their potential therapeutic applications DOI Creative Commons
Aparajita Sen,

Jyoti Oswalia,

Sneha Yadav

и другие.

Current Research in Biotechnology, Год журнала: 2024, Номер 7, С. 100205 - 100205

Опубликована: Янв. 1, 2024

Nanozymes are a class of nanoparticles that can mimic enzyme activity and be used for various applications in modern clinical therapy. It has recently been observed nanozymes have multi-enzyme mimicking activities, highly stable, versatile easily modified. Moreover, they high catalytic efficiency, recovery rates, improved substrate specificity suitable mass production. The mechanisms mainly include catalase, peroxidase, oxidase, hydrolase superoxide dismutase-like which enable to as potential therapeutics against plethora infectious lifestyle disorders. cancer, inflammatory diseases, neurodegenerative neurological disorders, bacterial, fungal viral infections, wounds diseases associated with Reactive Oxygen Species. purpose writing this review is provide comprehensive compilation novel research work taken place the last few years regarding use We compiled kinds elaborated on their anti-tumorigenic, antioxidant, anti-inflammatory, antibacterial, antifungal, antiviral, neuroprotective roles. Their modes action enzymatic targets also discussed. types synthesis summarized, along interactions nanozymes. Furthermore, strategies enhance compatibility between analyzed. Major focus laid therapeutic challenges future perspectives using therapy debated later sections.

Язык: Английский

Процитировано

17

Accelerated and Precise Identification of Antioxidants and Pesticides Using a Smartphone-Based Colorimetric Sensor Array DOI
Tian Luan, Yu Zhang,

Zhimin Song

и другие.

Talanta, Год журнала: 2024, Номер 277, С. 126275 - 126275

Опубликована: Май 22, 2024

Язык: Английский

Процитировано

12

Plasmon-Stimulated Colorimetry Biosensor Array for the Identification of Multiple Metabolites DOI
Lin Tian, Ming Cao,

Haorong Cheng

и другие.

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(6), С. 6849 - 6858

Опубликована: Янв. 31, 2024

Rationally designing highly catalytic and stable nanozymes for metabolite monitoring is of great importance because their huge potential in early disease diagnosis. Herein, a novel nanozyme based on hierarchically structured CuS/ZnS with efficient peroxidase (POD)-mimic capability was developed synthesized multiple determination recognition via the plasmon-stimulated biosensor array strategy. The designed can simultaneously harvest plasmon triggered hot electron–hole pairs generate photothermal properties, leading to sharply boosted POD-mimic under 808 nm laser irradiation. Interestingly, interaction diversity POD-like nanomaterials, unique inhibitory effect metabolites activity could be signal response as differentiation. Thus, utilizing TMB typical chromogenic substrate addition H2O2, colorimetric produce diverse fingerprints three vital metabolisms (cysteine (Cys), ascorbic acid (AA), glutathione (GSH)), which precisely identified by principal component analysis (PCA). Notably, distinct fingerprint single different levels mixtures also achieved detection limit 1 μM. Most importantly, cell lysis effectively discriminated assay, implying its clinical

Язык: Английский

Процитировано

11

Oil density and viscosity affect emulsion stability and destabilization mechanism DOI

Weiyi Zhang,

Yinghao Zhang,

Yifei He

и другие.

Journal of Food Engineering, Год журнала: 2023, Номер 366, С. 111864 - 111864

Опубликована: Ноя. 30, 2023

Язык: Английский

Процитировано

23

Development of a high-performance label-free electrochemical immunosensor for early cancer diagnosis using anti-CEA/Ag-MOF/GO/GCE nanocomposite DOI
Peng Huang, Lingzhang Meng, Jun Pang

и другие.

Environmental Research, Год журнала: 2023, Номер 238, С. 117178 - 117178

Опубликована: Сен. 20, 2023

Язык: Английский

Процитировано

21