Temperature-resilient and sustainable Mn-MOF oxidase-like nanozyme (UoZ-4) for total antioxidant capacity sensing in some citrus fruits: Breaking the temperature barrier

Food Chemistry, Journal Year: 2024, Volume and Issue: 448, P. 139170 - 139170

Published: March 29, 2024

Language: Английский

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Multi-signal sensor array based on a fluorescent nanozyme for broad-spectrum screening of pesticides

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 482, P. 148784 - 148784

Published: Jan. 17, 2024

Language: Английский

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Supercritical CO2 utilization for solubility measurement of Tramadol hydrochloride drug: Assessment of cubic and non-cubic EoSs

The Journal of Supercritical Fluids, Journal Year: 2024, Volume and Issue: 206, P. 106185 - 106185

Published: Jan. 9, 2024

Language: Английский

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Fluorescent Fingerprint Identification of Protein Structural Changes and Disease-Specific Amyloid Beta Aggregates Based on a Single-Nanozyme Sensor Array

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

The misfolding of amyloid β (Aβ) peptides into an aggregation state is a central hallmark the onset Alzheimer's disease (AD). However, conventional methods are mainly focused on detecting specific Aβ peptide, which makes it difficult to recognize multiple analytes with different topological features and unfolded states at same time. Here, we propose simple universal sensing strategy construct fluorescence sensor array by using single-nanozyme probe combined three fluorescent substrates as recognition units protein structural changes identify between assemblies. In this system, fingerprint-like patterns produced from nonspecific interactions proteins units. As result, can accurately 13 kinds their mixtures ratios. Moreover, discriminate against diverse conformational forms. Most importantly, successfully distinguishes species, even in artificial cerebrospinal fluid samples human serum samples. This work provides attractive reliable for predicting pathologically relevant clinical diagnosis AD.

Language: Английский

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A graphene oxide/polyaniline nanocomposite biosensor: synthesis, characterization, and electrochemical detection of bilirubin

RSC Advances, Journal Year: 2023, Volume and Issue: 13(51), P. 36280 - 36292

Published: Jan. 1, 2023

The level of free bilirubin is a considerable index for the characterization jaundice-related diseases. Herein, biosensor was fabricated via immobilization oxidase (BOx) on graphene oxide (GO) and polyaniline (PANI) that were electrochemically co-precipitated indium tin (ITO) conductive glass. structural enzyme electrode characterized by FTIR, XRD, Raman spectroscopy, while spectral thermal properties investigated UV-vis thermogravimetric analysis (TGA). Owing to activity BOx/GO@PANI/ITO biosensor, it could detect with good selectivity sensitivity in low response time. electrochemical studied using impedance spectroscopy (EIS) cyclic voltammetry (CV). At polarization potential 0.2 V vs. Ag/AgCl, sensor illustrated only 2 s at 30 °C pH 7.5. LOD LOQ calculated found be 0.15 nM 2.8 nM, respectively. signal showed linear concentration range 0.01-250 μM. 5 °C, demonstrated half-time 120 days, through which utilized 100 times this temperature conditions. By common colorimetric method, data levels serum determination coefficient (R2) 0.97.

Language: Английский

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Recent trends in nanozyme research and their potential therapeutic applications

Current Research in Biotechnology, Journal Year: 2024, Volume and Issue: 7, P. 100205 - 100205

Published: Jan. 1, 2024

Nanozymes are a class of nanoparticles that can mimic enzyme activity and be used for various applications in modern clinical therapy. It has recently been observed nanozymes have multi-enzyme mimicking activities, highly stable, versatile easily modified. Moreover, they high catalytic efficiency, recovery rates, improved substrate specificity suitable mass production. The mechanisms mainly include catalase, peroxidase, oxidase, hydrolase superoxide dismutase-like which enable to as potential therapeutics against plethora infectious lifestyle disorders. cancer, inflammatory diseases, neurodegenerative neurological disorders, bacterial, fungal viral infections, wounds diseases associated with Reactive Oxygen Species. purpose writing this review is provide comprehensive compilation novel research work taken place the last few years regarding use We compiled kinds elaborated on their anti-tumorigenic, antioxidant, anti-inflammatory, antibacterial, antifungal, antiviral, neuroprotective roles. Their modes action enzymatic targets also discussed. types synthesis summarized, along interactions nanozymes. Furthermore, strategies enhance compatibility between analyzed. Major focus laid therapeutic challenges future perspectives using therapy debated later sections.

Language: Английский

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Accelerated and Precise Identification of Antioxidants and Pesticides Using a Smartphone-Based Colorimetric Sensor Array

Talanta, Journal Year: 2024, Volume and Issue: 277, P. 126275 - 126275

Published: May 22, 2024

Language: Английский

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Plasmon-Stimulated Colorimetry Biosensor Array for the Identification of Multiple Metabolites

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(6), P. 6849 - 6858

Published: Jan. 31, 2024

Rationally designing highly catalytic and stable nanozymes for metabolite monitoring is of great importance because their huge potential in early disease diagnosis. Herein, a novel nanozyme based on hierarchically structured CuS/ZnS with efficient peroxidase (POD)-mimic capability was developed synthesized multiple determination recognition via the plasmon-stimulated biosensor array strategy. The designed can simultaneously harvest plasmon triggered hot electron–hole pairs generate photothermal properties, leading to sharply boosted POD-mimic under 808 nm laser irradiation. Interestingly, interaction diversity POD-like nanomaterials, unique inhibitory effect metabolites activity could be signal response as differentiation. Thus, utilizing TMB typical chromogenic substrate addition H2O2, colorimetric produce diverse fingerprints three vital metabolisms (cysteine (Cys), ascorbic acid (AA), glutathione (GSH)), which precisely identified by principal component analysis (PCA). Notably, distinct fingerprint single different levels mixtures also achieved detection limit 1 μM. Most importantly, cell lysis effectively discriminated assay, implying its clinical

Language: Английский

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Exploring the potential of lignin nanoparticles in enhancing the mechanical, thermal, and bioactive properties of poly (butylene adipate-co-terephthalate)

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 262, P. 129880 - 129880

Published: Feb. 1, 2024

Language: Английский

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Oil density and viscosity affect emulsion stability and destabilization mechanism

Journal of Food Engineering, Journal Year: 2023, Volume and Issue: 366, P. 111864 - 111864

Published: Nov. 30, 2023

Language: Английский

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