Fluorescent Aptasensor Based on Competitive Recognition Strategies and Point-of-Care Testing System for Brain Natriuretic Peptide Detection DOI

Ziyue Qin,

Shouzhe Deng,

Jiawang Wang

et al.

Published: Jan. 1, 2024

Language: Английский

Fluorescent Probe for Investigating the Mitochondrial Viscosity and Hydrogen Peroxide Changes in Cerebral Ischemia/Reperfusion Injury DOI
Cong Fang, Quan Deng,

Kuicheng Zhao

et al.

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(8), P. 3436 - 3444

Published: Feb. 19, 2024

Cerebral ischemia–reperfusion injury (CIRI), a cause of cerebral dysfunction during infarction treatment, is closely associated with mitochondrial viscosity and hydrogen peroxide (H2O2). However, the accurate measurement H2O2 levels in CIRI challenging because lack sufficient selectivity blood–brain barrier (BBB) penetration existing monitoring tools related to CIRI, hampering exploration role CIRI. To address this issue, we designed an activatable fluorescent probe, mitochondria-targeting styryl-quinolin-ium (Mito-IQS), excellent properties including high selectivity, targeting, BBB penetration, for visualization brain. Based on real-time capabilities bursts were visualized This probe can be used monitor therapeutic effects butylphthalein treatment. More importantly, vivo experiments further confirmed that was levels. discovery provides new insights study expected accelerate process diagnosis, drug design.

Language: Английский

Citations

22
Functionalized nanoscale metal oxides for biosensing, bioimaging and cancer therapy DOI
Di Zhao,

Bai Pin,

Aifang Zhou

et al.

TrAC Trends in Analytical Chemistry, Journal Year: 2024, Volume and Issue: 174, P. 117684 - 117684

Published: April 2, 2024

Language: Английский

Citations

9
Rational design of cascade reaction-assisted trinal-site fluorescent probe for simultaneous discrimination of Cys, Hcy, GSH, and H2S in living cells and zebrafish DOI
Qian Wang, Wenting Zhang,

Mingzhe Cai

et al.

Sensors and Actuators B Chemical, Journal Year: 2024, Volume and Issue: 418, P. 136151 - 136151

Published: July 4, 2024

Language: Английский

Citations

7
Multiphoton tools for hydrogen peroxide imaging in vivo with subcellular resolution DOI
Artem S. Chebotarev, Ilya V. Kelmanson, Alexandra D. Ivanova

et al.

Sensors and Actuators B Chemical, Journal Year: 2024, Volume and Issue: 410, P. 135646 - 135646

Published: March 16, 2024

Language: Английский

Citations

4
A Mitochondria-Targeted Fluorescent Probe for Revealing H2O2 Elevation Modulated by Basal HOCl in HeLa and A549 Cells DOI
Nan Yin, Yuting Wang, Guixin Qin

et al.

Sensors and Actuators B Chemical, Journal Year: 2024, Volume and Issue: 419, P. 136419 - 136419

Published: Aug. 4, 2024

Language: Английский

Citations

3
Chromenone Derivatives as Crm1 Inhibitors for Targeting Glioblastoma DOI
Wolfgang Link, Salvatore Princiotto, Lucía Jiménez

et al.

Published: Jan. 1, 2025

Glioblastoma (GBM) is one of the most aggressive and deadly cancers. Due to complexity redundancy within signaling networks in GBM, targeted inhibitors specific pathways have shown only limited success. The nuclear export receptor Chromosome Region Maintenance 1 (CRM1) has recently emerged as a promising therapeutic target, its inhibition can simultaneously disrupt multiple key oncogenic drivers. In this study, we explore whether chromenone derivatives, known for detecting thiol-containing molecules, function CRM1 inhibitors. We synthesized several chromenone-based derivatives demonstrated that they inhibit CRM1-driven structure- dose-dependent manner. A preliminary structure-activity relationship (SAR) was established, providing rationale selective binding based on molecular docking studies. Additionally, showed active effectively endogenous signal (NES)-containing substrates glioblastoma cells. Several these compounds exhibit cytotoxicity against cell lines, highlighting their potential therapies GBM.

Language: Английский

Citations

0
Enhanced Electrochemiluminescence Sensing of Brain Natriuretic Peptide (BNP) using Copper Nanocluster and Luminol-H2O2 based System in Heart Failure Diagnosis DOI

B. K. Arathy,

Merin K. Abraham,

Geneva Indongo

et al.

Talanta, Journal Year: 2025, Volume and Issue: 295, P. 128362 - 128362

Published: May 21, 2025

Language: Английский

Citations

0
A novel fluorescent probe for the detection of H2O2 in multiple food matrices and biological samples DOI
Yukun Zhang, G. M., Lie Li

et al.

Food Chemistry, Journal Year: 2025, Volume and Issue: 489, P. 144998 - 144998

Published: June 3, 2025

Language: Английский

Citations

0
The Effective Detection of Alzheimer in the System via ML Algorithm DOI

R. Kishore Kanna,

Kapil Joshi, Gunjan Chhabra

et al.

Published: May 14, 2024

Language: Английский

Citations

1
Fluorescent aptasensor based on competitive recognition strategies and point-of-care testing system for brain natriuretic peptide detection DOI

Ziyue Qin,

Shouzhe Deng,

Jiawang Wang

et al.

Microchemical Journal, Journal Year: 2024, Volume and Issue: unknown, P. 111742 - 111742

Published: Sept. 1, 2024

Language: Английский

Citations

1