Region-specific cellular and molecular basis of liver regeneration after acute pericentral injury

Cell stem cell, Год журнала: 2024, Номер 31(3), С. 341 - 358.e7

Опубликована: Фев. 22, 2024

Язык: Английский

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Dual-mode action of scalable, high-quality engineered stem cell-derived SIRPα-extracellular vesicles for treating acute liver failure

Nature Communications, Год журнала: 2025, Номер 16(1)

Опубликована: Фев. 23, 2025

Язык: Английский

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Fetal liver development and implications for liver disease pathogenesis

Nature Reviews Gastroenterology & Hepatology, Год журнала: 2023, Номер 20(9), С. 561 - 581

Опубликована: Май 19, 2023

Язык: Английский

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Single-cell atlas of the human neonatal small intestine affected by necrotizing enterocolitis

PLoS Biology, Год журнала: 2023, Номер 21(5), С. e3002124 - e3002124

Опубликована: Май 19, 2023

Necrotizing enterocolitis (NEC) is a gastrointestinal complication of premature infants with high rates morbidity and mortality. A comprehensive view the cellular changes aberrant interactions that underlie NEC lacking. This study aimed at filling in this gap. We combine single-cell RNA sequencing (scRNAseq), T-cell receptor beta (TCRβ) analysis, bulk transcriptomics, imaging to characterize cell identities, interactions, zonal NEC. find an abundance proinflammatory macrophages, fibroblasts, endothelial cells as well T exhibit increased TCRβ clonal expansion. Villus tip epithelial are reduced remaining up-regulate genes. establish detailed map epithelial–mesenchymal–immune associated inflammation mucosa. Our analyses highlight dysregulations NEC-associated intestinal tissue identify potential targets for biomarker discovery therapeutics.

Язык: Английский

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Decoding aging-dependent regenerative decline across tissues at single-cell resolution

Cell stem cell, Год журнала: 2023, Номер 30(12), С. 1674 - 1691.e8

Опубликована: Окт. 27, 2023

Язык: Английский

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