Single-cell atlas of the human neonatal small intestine affected by necrotizing enterocolitis DOI Creative Commons

Adi Egozi,

Oluwabunmi Olaloye, Lael Werner

и другие.

PLoS Biology, Год журнала: 2023, Номер 21(5), С. e3002124 - e3002124

Опубликована: Май 19, 2023

Necrotizing enterocolitis (NEC) is a gastrointestinal complication of premature infants with high rates morbidity and mortality. A comprehensive view the cellular changes aberrant interactions that underlie NEC lacking. This study aimed at filling in this gap. We combine single-cell RNA sequencing (scRNAseq), T-cell receptor beta (TCRβ) analysis, bulk transcriptomics, imaging to characterize cell identities, interactions, zonal NEC. find an abundance proinflammatory macrophages, fibroblasts, endothelial cells as well T exhibit increased TCRβ clonal expansion. Villus tip epithelial are reduced remaining up-regulate genes. establish detailed map epithelial–mesenchymal–immune associated inflammation mucosa. Our analyses highlight dysregulations NEC-associated intestinal tissue identify potential targets for biomarker discovery therapeutics.

Язык: Английский

Region-specific cellular and molecular basis of liver regeneration after acute pericentral injury DOI Creative Commons
Shuyong Wang, Xuan Wang, Yiran Shan

и другие.

Cell stem cell, Год журнала: 2024, Номер 31(3), С. 341 - 358.e7

Опубликована: Фев. 22, 2024

Язык: Английский

Процитировано

10
Dual-mode action of scalable, high-quality engineered stem cell-derived SIRPα-extracellular vesicles for treating acute liver failure DOI Creative Commons
Seohyun Kim, Yoon Kyoung Kim, Seonghyun Kim

и другие.

Nature Communications, Год журнала: 2025, Номер 16(1)

Опубликована: Фев. 23, 2025

Язык: Английский

Процитировано

2
Fetal liver development and implications for liver disease pathogenesis DOI
Jeremy Lotto, Tabea L. Stephan, Pamela A. Hoodless

и другие.

Nature Reviews Gastroenterology & Hepatology, Год журнала: 2023, Номер 20(9), С. 561 - 581

Опубликована: Май 19, 2023

Язык: Английский

Процитировано

20
Decoding aging-dependent regenerative decline across tissues at single-cell resolution DOI Creative Commons
Yusheng Cai,

Muzhao Xiong,

Zijuan Xin

и другие.

Cell stem cell, Год журнала: 2023, Номер 30(12), С. 1674 - 1691.e8

Опубликована: Окт. 27, 2023

Язык: Английский

Процитировано

19
Single-cell atlas of the human neonatal small intestine affected by necrotizing enterocolitis DOI Creative Commons

Adi Egozi,

Oluwabunmi Olaloye, Lael Werner

и другие.

PLoS Biology, Год журнала: 2023, Номер 21(5), С. e3002124 - e3002124

Опубликована: Май 19, 2023

Necrotizing enterocolitis (NEC) is a gastrointestinal complication of premature infants with high rates morbidity and mortality. A comprehensive view the cellular changes aberrant interactions that underlie NEC lacking. This study aimed at filling in this gap. We combine single-cell RNA sequencing (scRNAseq), T-cell receptor beta (TCRβ) analysis, bulk transcriptomics, imaging to characterize cell identities, interactions, zonal NEC. find an abundance proinflammatory macrophages, fibroblasts, endothelial cells as well T exhibit increased TCRβ clonal expansion. Villus tip epithelial are reduced remaining up-regulate genes. establish detailed map epithelial–mesenchymal–immune associated inflammation mucosa. Our analyses highlight dysregulations NEC-associated intestinal tissue identify potential targets for biomarker discovery therapeutics.

Язык: Английский

Процитировано

18