Region-specific cellular and molecular basis of liver regeneration after acute pericentral injury

Cell stem cell, Journal Year: 2024, Volume and Issue: 31(3), P. 341 - 358.e7

Published: Feb. 22, 2024

Language: Английский

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Biomimetic hepatic lobules from three-dimensional imprinted cell sheets

Science Bulletin, Journal Year: 2024, Volume and Issue: 69(10), P. 1448 - 1457

Published: Feb. 28, 2024

Language: Английский

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Myeloid‐Mas Signaling Modulates Pathogenic Crosstalk among MYC⁺CD63⁺ Endothelial Cells, MMP12⁺ Macrophages, and Monocytes in Acetaminophen‐Induced Liver Injury

Advanced Science, Journal Year: 2024, Volume and Issue: 11(16)

Published: Feb. 13, 2024

Acetaminophen overdose is a leading cause of acute liver failure (ALF). Despite the pivotal role inflammatory microenvironment in progression advanced acetaminophen-induced injury (AILI), comprehensive understanding underlying cellular interactions and molecular mechanisms remains elusive. Mas G protein-coupled receptor highly expressed by myeloid cells; however, its AILI to be elucidated. A multidimensional approach, including single-cell RNA sequencing, spatial transcriptomics, hour-long intravital imaging, employed characterize Mas1 deficient mice at systemic cell-specific levels. The characteristic landscape mouse models involves reciprocal communication among MYC

Language: Английский

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Dual-mode action of scalable, high-quality engineered stem cell-derived SIRPα-extracellular vesicles for treating acute liver failure

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 23, 2025

Language: Английский

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Fetal liver development and implications for liver disease pathogenesis

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2023, Volume and Issue: 20(9), P. 561 - 581

Published: May 19, 2023

Language: Английский

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