How age affects human hematopoietic stem and progenitor cells and strategies to mitigate HSPC aging

Experimental Hematology, Год журнала: 2025, Номер unknown, С. 104711 - 104711

Опубликована: Янв. 1, 2025

Язык: Английский

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Ageing-related bone and immunity changes: insights into the complex interplay between the skeleton and the immune system

Bone Research, Год журнала: 2024, Номер 12(1)

Опубликована: Авг. 5, 2024

Abstract Ageing as a natural irreversible process inherently results in the functional deterioration of numerous organ systems and tissues, including skeletal immune systems. Recent studies have elucidated intricate bidirectional interactions between these two In this review, we provide comprehensive synthesis molecular mechanisms cell ageing. We further discuss how age-related changes influence system consequent impact alterations on system. Finally, highlight clinical implications findings propose potential strategies to promote healthy ageing reduce pathologic both

Язык: Английский

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Autophagy counters inflammation-driven glycolytic impairment in aging hematopoietic stem cells

Cell stem cell, Год журнала: 2024, Номер 31(7), С. 1020 - 1037.e9

Опубликована: Май 15, 2024

Язык: Английский

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SDHAF1 confers metabolic resilience to aging hematopoietic stem cells by promoting mitochondrial ATP production

Cell stem cell, Год журнала: 2024, Номер 31(8), С. 1145 - 1161.e15

Опубликована: Май 20, 2024

Язык: Английский

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Bone marrow niches for hematopoietic stem cells: life span dynamics and adaptation to acute stress

Blood, Год журнала: 2024, Номер 144(1), С. 21 - 34

Опубликована: Апрель 5, 2024

Язык: Английский

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The role of the haematopoietic stem cell niche in development and ageing

Nature Reviews Molecular Cell Biology, Год журнала: 2024, Номер unknown

Опубликована: Сен. 10, 2024

Язык: Английский

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KBTBD4-mediated reduction of MYC is critical for hematopoietic stem cell expansion upon UM171 treatment

Blood, Год журнала: 2024, Номер 143(10), С. 882 - 894

Опубликована: Янв. 11, 2024

Язык: Английский

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Unraveling the pathogenesis of bone marrow hematopoietic injury and the therapeutic potential of natural products

Pharmacological Research, Год журнала: 2025, Номер unknown, С. 107589 - 107589

Опубликована: Янв. 1, 2025

Bone marrow hematopoietic injury encompasses a range of pathological conditions that disrupt the normal function system, primarily through impaired production and differentiation bone cells. Key pathogenic mechanisms include aging, radiation damage, chemical induction, infection inflammation, cross-talk with non-hematopoietic diseases. These factors often lead to myelosuppression myeloid skewing. Furthermore, we explored potential application prospects natural products in treatment injury. Natural products, particularly those derived from Chinese herbal medicines other sources, have emerged as promising therapeutic options due their distinctive minimal side effects. A deeper understanding underlying could illuminate how exert effects, thereby optimizing strategies offering safer, more effective for patients. Future research should leverage emerging technologies further elucidate composition interactions within microenvironment, well specific pathways which modulate dysfunction.

Язык: Английский

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Mitochondrial serine catabolism safeguards maintenance of the hematopoietic stem cell pool in homeostasis and injury

Cell stem cell, Год журнала: 2024, Номер 31(10), С. 1484 - 1500.e9

Опубликована: Авг. 23, 2024

Язык: Английский

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IFN alpha signaling drives hematopoietic stem cells malfunction under acute inflammation

International Immunopharmacology, Год журнала: 2025, Номер 147, С. 114012 - 114012

Опубликована: Янв. 6, 2025

Язык: Английский

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