International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(16), С. 8815 - 8815
Опубликована: Авг. 13, 2024
The
adult
mammalian
heart
has
been
demonstrated
to
be
endowed
with
low
but
real
turnover
capacity,
especially
for
cardiomyocytes,
the
key
functional
cell
type.
source,
however,
of
that
capacity
remains
controversial.
In
this
regard,
we
have
defined
and
characterized
a
resident
multipotent
cardiac
mouse
progenitor
population,
Bmi1+DR
(for
Bmi1+
Damage-Responsive
cells).
is
one
types
lowest
ROS
(Reactive
Oxygen
Species)
levels
in
heart,
being
particularly
by
their
close
relationship
vessels,
most
probably
involved
regulation
proliferation/maintenance
Bmi1+DR.
This
was
proposed
work
as
endothelial
niche.
Due
scarcity
cells
generated
an
immortalization/dis-immortalization
model
using
Simian
Vacuolating
Virus
40-Large
Antigen
T
(SV40-T)
facilitate
vitro
characterization.
We
obtained
heterogeneous
population
immortalized
(Bmi1+DRIMM)
validated
attending
different
criteria,
also
showing
comparable
sensitivity
strong
oxidative
damage.
Then,
concluded
Bmi1-DRIMM
appropriate
primary
studies.
co-culture
Bmi1+DRIMM
protects
them
against
damage,
moderate
depletion
non-canonical
autophagy
contributing
modest
metabolic
regulation.
Frontiers in Cell and Developmental Biology,
Год журнала:
2024,
Номер
12
Опубликована: Сен. 12, 2024
To
enhance
the
practical
application
of
intestinal
organoids,
it
is
imperative
to
establish
standardized
guidelines.
This
proposed
standardization
outlines
a
comprehensive
framework
ensure
consistency
and
reliability
in
development,
characterization,
organoids.
The
recommended
guidelines
encompass
crucial
parameters,
including
culture
conditions,
critical
quality
attributes,
control
measures,
functional
assessments,
aimed
at
fostering
approach
across
diverse
research
initiatives.
implementation
these
anticipated
significantly
contribute
reproducibility
comparability
results
burgeoning
field
organoid
research.
The Journal of Experimental Medicine,
Год журнала:
2024,
Номер
221(5)
Опубликована: Апрель 18, 2024
The
creation
of
synthetic
T
cell
states
has
captivated
the
field
cell-based
therapies.
Wang
et
al.
(https://doi.org/10.1084/jem.20232368)
describe
how
disruption
BCOR
and
ZC3H12A
unleashes
anti-tumor
cells
with
unprecedented
lifespan
killer
instinct.
Are
we
witnessing
birth
immortal
super-soldiers
in
medicine?
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Фев. 15, 2024
Abstract
Tissue
maintenance
is
underpinned
by
resident
stem
cells
whose
activity
modulated
microenvironmental
cues.
Using
Drosophila
as
a
simple
model
to
identify
regulators
of
cell
behaviour
and
survival
in
vivo
,
we
have
identified
novel
connections
between
the
conserved
transmembrane
proteoglycan
Syndecan,
nuclear
properties
function.
In
midgut,
Syndecan
depletion
intestinal
results
their
loss
from
tissue,
impairing
tissue
renewal.
At
cellular
level,
alters
shape,
causes
lamina
invaginations
DNA
damage.
second
developing
brain,
live
imaging
revealed
that
neural
envelope
remodelling
defects
which
arise
upon
division.
Our
findings
reveal
new
role
for
diverse
types.
Graphical
Experimental Gerontology,
Год журнала:
2024,
Номер
194, С. 112508 - 112508
Опубликована: Июль 9, 2024
hTERT
gene
therapies
hold
significant
promise
for
treating
age-related
diseases.
However,
further
research
is
required
to
address
the
challenges
of
delivery
and
ethical
considerations.
We
hypothesized
that
exosomes
derived
from
hTERT-immortalized
cells
could
function
similarly
by
maintaining
telomere
length
attenuating
cellular
senescence
biomarkers.
In
this
study,
we
overexpressed
in
Human
Foreskin
Fibroblast-1
(HFF
cells)
produce
HFF
(hT-HFF
cells).
then
used
these
hT-HFF
treat
human
fibroblasts,
cells.
Our
results
demonstrated
effectively
attenuated
biomarkers
Furthermore,
analysis
revealed
mRNA
was
indeed
packaged
into
This
capable
elongating
telomeres
delaying
Therefore,
show
potential
as
a
treatment
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(16), С. 8815 - 8815
Опубликована: Авг. 13, 2024
The
adult
mammalian
heart
has
been
demonstrated
to
be
endowed
with
low
but
real
turnover
capacity,
especially
for
cardiomyocytes,
the
key
functional
cell
type.
source,
however,
of
that
capacity
remains
controversial.
In
this
regard,
we
have
defined
and
characterized
a
resident
multipotent
cardiac
mouse
progenitor
population,
Bmi1+DR
(for
Bmi1+
Damage-Responsive
cells).
is
one
types
lowest
ROS
(Reactive
Oxygen
Species)
levels
in
heart,
being
particularly
by
their
close
relationship
vessels,
most
probably
involved
regulation
proliferation/maintenance
Bmi1+DR.
This
was
proposed
work
as
endothelial
niche.
Due
scarcity
cells
generated
an
immortalization/dis-immortalization
model
using
Simian
Vacuolating
Virus
40-Large
Antigen
T
(SV40-T)
facilitate
vitro
characterization.
We
obtained
heterogeneous
population
immortalized
(Bmi1+DRIMM)
validated
attending
different
criteria,
also
showing
comparable
sensitivity
strong
oxidative
damage.
Then,
concluded
Bmi1-DRIMM
appropriate
primary
studies.
co-culture
Bmi1+DRIMM
protects
them
against
damage,
moderate
depletion
non-canonical
autophagy
contributing
modest
metabolic
regulation.
