Measurement and Modeling of the Solubility of Mebeverine Hydrochloride in Supercritical Carbon Dioxide

Chemical Engineering & Technology, Год журнала: 2024, Номер 47(5), С. 811 - 821

Опубликована: Апрель 1, 2024

Abstract Mebeverine hydrochloride is an important drug to treat irritable bowel syndrome. The solubility of this in supercritical carbon dioxide was measured at temperatures from 35 65 °C and pressures 12 30 MPa. Results were between 2.16 30.2 ppm by mole. data correlated with density‐based models (K‐J, MST, Chrastil, Garlapati Madras, Bartle et al., Sparks al.) equations state (Peng‐Robinson, Soave, Estévez al. models). mean relative deviation corrected correlation coefficient used assess the goodness models. Based on all ten models, performed best according average absolute (5.64 %), R adj (0.997). However, contribution's main merit reported experimental data.

Язык: Английский

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Preparation of Erlotinib hydrochloride nanoparticles (anti-cancer drug) by RESS-C method and investigating the effective parameters

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Июнь 28, 2024

The size of the drug particles is one essential factors for proper absorption compared to dose drug. When particle decreased, uptake into body increases. Recent studies have revealed that rapid expansion supercritical solution with cosolvent plays a significant role in preparing micron and submicron particles. This paper examines preparation Erlotinib hydrochloride nanoparticles using through method first time. An examination parameters temperature (318-338 K), pressures (15-25 MPa) nozzle diameter (300-700 μm) was investigated by Box-Behnken design, their respective effects on has more impact than other parameters. smallest were produced at 338 K, pressure 20 MPa, 700 μm. Besides, ERL characterized SEM, DLS, XRD, FTIR, DSC analyses. Finally, results showed average decreased from 31.6 μm 200-1100 nm.

Язык: Английский

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Study of Baclofen Solubility in Supercritical CO₂ with and without Cosolvents: Experimental Analysis, Thermodynamic Evaluation, and Machine Learning Methods

Journal of Chemical & Engineering Data, Год журнала: 2025, Номер unknown

Опубликована: Янв. 15, 2025

This study investigates the solubility of Baclofen in supercritical CO2, which is essential for developing an efficient drug delivery system using processes. Solubility measurements were carried out both with and without presence various cosolvents (ethanol dimethyl sulfoxide (DMSO)), across a temperature range 308–338 K pressure 12–30 MPa. exhibited ranging from 1.62 × 10–5 to 2.30 mole fractions pure CO2. In cosolvents, increased 5.76 12.79 ethanol 3.50 7.02 DMSO. Indeed, addition DMSO by approximately 3.55–5.56 times 2.15–3.05 times, respectively. Several density-based empirical models thermodynamic (Soave–Redlich–Kwong (SRK) Peng–Robinson (PR) equations state) used correlate data. Jafari Nejad's model CO2–Baclofen Jouyban's CO2–ethanol/DMSO–Baclofen systems displayed higher consistency. Also, PR showed better accuracy correlating while SRK outperformed CO2–ethanol/DMSO cosolvents. Moreover, machine learning exceptional accuracy, over 99% predictions closely matching experimental data, emphasizing its outstanding performance.

Язык: Английский

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Investigating the Influence of Cosolvents on the Solubility of Febuxostat in Supercritical CO₂: Experimental Analysis and Artificial Intelligence Study

Journal of Chemical & Engineering Data, Год журнала: 2024, Номер 69(7), С. 2569 - 2584

Опубликована: Июль 1, 2024

Assessing the solubility of pharmaceutical compounds in supercritical carbon dioxide (scCO2) is a fundamental prerequisite for advancing application technologies sector. The Febuxostat, drug with limited often prescribed gout patients to lower blood uric acid levels, has previously been studied within pressure and temperature ranges 12–27 MPa 308–338 K, exhibiting mole fraction range 0.05 × 10–4–7.42 10–4. This study explores influence various cosolvents, namely, ethanol, acetone, dimethyl sulfoxide (DMSO), on Febuxostat under comparable conditions. Results indicate 0.180 10–4–26.658 10–4 0.120 10–4–14.810 0.108 10–4–14.366 DMSO, respectively. Ethanol exhibits most substantial impact, enhancing by approximately 2.4–3.8 times, while acetone DMSO contribute an increase 2–2.5 times. Furthermore, employs empirical models artificial neural network (ANN) approach theoretically investigate these cosolvents. Among models, Jouyban model demonstrates accurate correlation data all Moreover, ANN exceptional accuracy forecasting mean AARD % 3.207% Radj 0.993 across experimental measurements scCO2 + solvents.

Язык: Английский

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Pregabalin solubility in supercritical green solvent: A comprehensive experimental and theoretical-intelligent assessment

Journal of Molecular Liquids, Год журнала: 2024, Номер 408, С. 125339 - 125339

Опубликована: Авг. 1, 2024

Язык: Английский

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A comprehensive study of pharmaceutics solubility in supercritical solvent through diverse thermodynamic and hybrid Machine learning approaches

International Journal of Pharmaceutics, Год журнала: 2024, Номер 664, С. 124579 - 124579

Опубликована: Авг. 11, 2024

Язык: Английский

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Comprehensive study of medications solubility in supercritical CO2 with and without co-solvent; Laboratory, theoretical, and intelligent approaches

Journal of Molecular Liquids, Год журнала: 2024, Номер 411, С. 125765 - 125765

Опубликована: Авг. 13, 2024

Язык: Английский

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Supercritical CO2 green solvent extraction of Nepeta crispa: Evaluation of process optimization, chemical analysis, and biological activity

The Journal of Supercritical Fluids, Год журнала: 2024, Номер 216, С. 106451 - 106451

Опубликована: Ноя. 4, 2024

Язык: Английский

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Measurement and Modeling of Zolpidem Solubility in Supercritical Carbon Dioxide: Effect of Two Cosolvents

Journal of Chemical & Engineering Data, Год журнала: 2024, Номер 69(5), С. 1966 - 1983

Опубликована: Апрель 17, 2024

Obtaining data on the solubility of zolpidem, a sedative–hypnotic drug, in supercritical CO2 (scCO2) is crucial step development an efficient process designed to formulate effective drug delivery system for this medication. The current investigation entailed determining substance scCO2 across range temperatures (308.0, 318.0, 328.0, 338.0, and 348.0 K) pressure values between 17 41 MPa. Furthermore, research delved into assessing impact two cosolvents, DMSO ethanol, under given conditions. zolpidem was within mole fraction 1.19 × 10–4–3.23 10–4. However, when ethanol were introduced, solubilities enhanced ranges 3.09 10–4–22.13 10–4 1.31 10–4–12.44 10–4, respectively. It noted that more substantial, leading approximately 4–5 times improvement zolpidem. Utilizing validated empirical models correlate both scCO2–zolpidem scCO2–ethanol–zolpidem systems, it observed developed by Nejad Keshmiri zolpidem–scCO2 (AARD% ≈ 1.50 Radj = 0.996) MST–Sauceau zolpidem–scCO2–ethanol 3.51 0.995) exhibited highest levels consistency predicted actual experimental data. Also, binary evaluated using SRK UNIQUAC models. model demonstrated exceptional accuracy 1.53 0.999) modeling scCO2.

Язык: Английский

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Determination of the solubility of methyldopa in supercritical carbon dioxide for drug delivery applications: thermal analysis

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Янв. 6, 2025

The production of fine particles by green technology like supercritical carbon dioxide requires the assessment substantial solubility data at high pressures. This study represents first determination methyldopa in pressures and temperatures ranging from 12 to 30 MPa 313.2 343.2 K, respectively. mole fractions were obtained under aforementioned conditions ranged 0.805 × 10⁻5 11.345 10⁻5. Four empirical models (Chrastil, Bartle et al., Mendez-Santiago, & Teja, Kumar-Johnston) two equations state (Peng-Robinson Soave-Redlich-Kwong) used correlate drug solubility. K-J model demonstrated highest accuracy, with an AARD 8.38% a R2 value 0.988. Furthermore, enthalpy values for SC-CO₂ estimated using Chrastil models, resulting 34.35 56.87 kJ·mol⁻¹, results demonstrate that SRK more pronounced than PR model, AARD% 23.03 0.903 compared 26.42 0.837. article's conclusions provide valuable reference application method methyldopa.

Язык: Английский

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