Reno protective potential of taxifolin liposomes modified by chitosan in diabetic mice
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
306, С. 141464 - 141464
Опубликована: Фев. 25, 2025
Язык: Английский
Curcumin alleviates atrazine-induced nephrotoxicity by enhancing mitophagy through PINK1/Parkin signaling pathway in mice
Ecotoxicology and Environmental Safety,
Год журнала:
2025,
Номер
295, С. 118118 - 118118
Опубликована: Апрель 1, 2025
Atrazine
(ATR),
a
widely
used
herbicide,
poses
significant
environmental
and
health
risks
due
to
its
high
solubility
adsorption
in
soil.
ATR
exposure
can
lead
nephrotoxicity
humans
animals.
Curcumin
(Cur),
an
active
compound
Curcuma
species,
is
renowned
for
antioxidant
anti-inflammatory
properties,
with
potential
mitigate
chronic
disease
risks.
We
hypothesized
that
the
addition
of
Cur
could
alleviate
renal
impairment
associated
carried
out
experiments
using
mice
as
subjects.
This
study
investigates
whether
attenuate
ATR-induced
by
modulating
mitophagy
apoptotic
pathways.
Our
findings
illustrate
consumption
attenuates
induced
ATR,
evidenced
lowered
serum
concentrations
uric
acid
(UA),
blood
urea
nitrogen
(BUN),
creatinine
(CRE),
established
biomarkers
injury.
Moreover,
enhances
defense
mechanisms
ATR-exposed
mice,
indicated
elevated
levels
total
capacity
(T-AOC),
catalase
(CAT),
glutathione
peroxidase
(GSH-Px),
alongside
reduced
malondialdehyde
(MDA).
Histopathological
electron
microscopy
analyses
further
corroborate
these
findings,
showing
organelle
damage,
particularly
mitochondrial
ridge
breakage
vacuolization,
increased
autophagic
lysosomes.
PINK1/Parkin-mediated
autophagy,
PINK1,
Parkin,
LC3BII,
P62
compared
ATR-treated
mice.
mitigates
pathway,
down-regulation
apoptosis-related
genes
(Cytochrome
C
(Cyto-C),
Caspase3,
Caspase9)
pro-apoptotic
marker
(Bax),
along
up-regulation
anti-apoptotic
(Bcl-2)
at
both
transcriptional
translational
In
summary,
demonstrates
nephroprotective
properties
against
injury
through
enhancement
autophagy
display
actions,
underscoring
curative
potency
treatment
caused
ATR.
Язык: Английский
Zinc oxide nanoparticle mediated approaches for wound healing
Elsevier eBooks,
Год журнала:
2025,
Номер
unknown, С. 263 - 281
Опубликована: Янв. 1, 2025
Язык: Английский
Lycopene mitigates atrazine-induced hypothalamic neural stem cell senescence by modulating the integrated stress response pathway
Phytomedicine,
Год журнала:
2024,
Номер
135, С. 156114 - 156114
Опубликована: Сен. 30, 2024
Язык: Английский
Acrylamide-targeting renal miR−21a−5p/Fibrotic and miR122-5p/ inflammatory signaling pathways and the role of a green approach for nano-zinc detected via in silico and in vivo approaches
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Июль 17, 2024
Introduction:
Any
disruption
in
renal
function
can
have
cascading
effects
on
overall
health.
Understanding
how
a
heat-born
toxicant
like
acrylamide
(ACR)
affects
kidney
tissue
is
vital
for
realizing
its
broader
implications
systemic
Methods:
This
study
investigated
the
ACR-induced
damage
mechanisms,
particularly
focusing
regulating
role
of
miR-21a-5p/fibrotic
and
miR-122-5p/inflammatory
signaling
pathways
via
targeting
Timp-3
TP53
proteins
an
In
silico
preliminary
study.
Besides,
assessment,
oxidative
status,
protein
profile,
expression
biomarkers
(Timp-1,
Keap-1,
Kim-1,
P53,
TNF-α,
Bax,
Caspase3)
were
assessed
60-day
experiment.
The
examination
was
additionally
extended
to
explore
potential
protective
green-synthesized
zinc
oxide
nanoparticles
(ZNO-MONPs).
A
four-group
experiment
including
control,
ZNO-MONPs
(10
mg/kg
b.wt.),
ACR
(20
+
established
encompassing
biochemical,
histological,
molecular
levels.
further
protein-binding
ability
ZNO
MONPs
inactivate
caspase-3,
TNFRS-1A.
Results:
significantly
reduced
as
evidenced
by
increased
serum
creatinine,
uric
acid,
albumin,
stress
markers.
stress,
apoptosis,
inflammationare
revealed
biochemical
tests,
gene
expression,
presence
apoptotic
nuclei
microscopically.
Also,
docking
binding
affinity
between
ACR-BCL-2
glutathione-synthetase,
elucidating
mechanisms
through
which
induces
damage.
Notably,
against
Zn
levels
tissues
ACR-exposed
rats
restored
those
treated
with
ZNO-MONPs.
conclusion,
this
establishes
efficacy
mitigating
disturbances
functions,
inflammation,
apoptosis.
findings
shed
light
renoprotective
activity
nanomaterials,
offering
insights
into
novel
therapeutic
approaches
countering
Язык: Английский
The interplay of oxidative stress, apoptotic signaling, and impaired mitochondrial function in the pyrethroid-induced cardiac injury: Alleviative role of curcumin-loaded chitosan nanoparticle
Food and Chemical Toxicology,
Год журнала:
2024,
Номер
194, С. 115095 - 115095
Опубликована: Ноя. 6, 2024
Язык: Английский
The mechanistic pathway induced by fenpropathrin toxicity: Oxidative stress, signaling pathway, and mitochondrial damage
Journal of Biochemical and Molecular Toxicology,
Год журнала:
2024,
Номер
38(11)
Опубликована: Окт. 17, 2024
Abstract
Fenpropathrin
(FNP)
is
a
kind
of
insecticide
and
acaricide
known
as
pyrethroid.
It
very
effective,
has
wide
range
activities,
works
quickly.
Internationally,
it
commonly
considered
the
most
powerful
pyrethroid
insecticide.
Nevertheless,
an
increasing
amount
data
indicates
substantial
link
between
adverse
effects
on
nontarget
species,
including
liver
toxicity,
kidney
nerve
damage,
reproductive
toxicity.
Oxidative
stress
plays
vital
role
in
toxicity
fenpropathrin,
addition
to
its
mechanical
mechanism.
This
study
offers
thorough
examination
harmful
oxidative
mitochondrial
processes,
well
signaling
pathways
involved
these
effects.
The
significant
impact
emphasizes
Fenpropathrin.
Язык: Английский