The mechanistic pathway induced by fenpropathrin toxicity: Oxidative stress, signaling pathway, and mitochondrial damage DOI
Soliman Mm, Adel F. Tohamy, Abdelbary Prince

et al.

Journal of Biochemical and Molecular Toxicology, Journal Year: 2024, Volume and Issue: 38(11)

Published: Oct. 17, 2024

Abstract Fenpropathrin (FNP) is a kind of insecticide and acaricide known as pyrethroid. It very effective, has wide range activities, works quickly. Internationally, it commonly considered the most powerful pyrethroid insecticide. Nevertheless, an increasing amount data indicates substantial link between adverse effects on nontarget species, including liver toxicity, kidney nerve damage, reproductive toxicity. Oxidative stress plays vital role in toxicity fenpropathrin, addition to its mechanical mechanism. This study offers thorough examination harmful oxidative mitochondrial processes, well signaling pathways involved these effects. The significant impact emphasizes Fenpropathrin.

Language: Английский

Reno protective potential of taxifolin liposomes modified by chitosan in diabetic mice DOI
Yingchun Zhao,

Qiteng Ding,

Qingbin He

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 306, P. 141464 - 141464

Published: Feb. 25, 2025

Language: Английский

Citations

0
Curcumin alleviates atrazine-induced nephrotoxicity by enhancing mitophagy through PINK1/Parkin signaling pathway in mice DOI Creative Commons

Zhenyu Zou,

Xinyi Cheng, Jinyan Chen

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 295, P. 118118 - 118118

Published: April 1, 2025

Atrazine (ATR), a widely used herbicide, poses significant environmental and health risks due to its high solubility adsorption in soil. ATR exposure can lead nephrotoxicity humans animals. Curcumin (Cur), an active compound Curcuma species, is renowned for antioxidant anti-inflammatory properties, with potential mitigate chronic disease risks. We hypothesized that the addition of Cur could alleviate renal impairment associated carried out experiments using mice as subjects. This study investigates whether attenuate ATR-induced by modulating mitophagy apoptotic pathways. Our findings illustrate consumption attenuates induced ATR, evidenced lowered serum concentrations uric acid (UA), blood urea nitrogen (BUN), creatinine (CRE), established biomarkers injury. Moreover, enhances defense mechanisms ATR-exposed mice, indicated elevated levels total capacity (T-AOC), catalase (CAT), glutathione peroxidase (GSH-Px), alongside reduced malondialdehyde (MDA). Histopathological electron microscopy analyses further corroborate these findings, showing organelle damage, particularly mitochondrial ridge breakage vacuolization, increased autophagic lysosomes. PINK1/Parkin-mediated autophagy, PINK1, Parkin, LC3BII, P62 compared ATR-treated mice. mitigates pathway, down-regulation apoptosis-related genes (Cytochrome C (Cyto-C), Caspase3, Caspase9) pro-apoptotic marker (Bax), along up-regulation anti-apoptotic (Bcl-2) at both transcriptional translational In summary, demonstrates nephroprotective properties against injury through enhancement autophagy display actions, underscoring curative potency treatment caused ATR.

Language: Английский

Citations

0
Zinc oxide nanoparticle mediated approaches for wound healing DOI
Amany Abdel-Rahman Mohamed, Yasmina M. Abd‐Elhakim

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 263 - 281

Published: Jan. 1, 2025

Language: Английский

Citations

0
Lycopene mitigates atrazine-induced hypothalamic neural stem cell senescence by modulating the integrated stress response pathway DOI
Jian Chen, Xueyan Dai, Xiao‐Wei Li

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 135, P. 156114 - 156114

Published: Sept. 30, 2024

Language: Английский

Citations

3
Acrylamide-targeting renal miR−21a−5p/Fibrotic and miR122-5p/ inflammatory signaling pathways and the role of a green approach for nano-zinc detected via in silico and in vivo approaches DOI Creative Commons
Leena S. Alqahtani, Manal E. Alosaimi, Amany Abdel-Rahman Mohamed

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: July 17, 2024

Introduction: Any disruption in renal function can have cascading effects on overall health. Understanding how a heat-born toxicant like acrylamide (ACR) affects kidney tissue is vital for realizing its broader implications systemic Methods: This study investigated the ACR-induced damage mechanisms, particularly focusing regulating role of miR-21a-5p/fibrotic and miR-122-5p/inflammatory signaling pathways via targeting Timp-3 TP53 proteins an In silico preliminary study. Besides, assessment, oxidative status, protein profile, expression biomarkers (Timp-1, Keap-1, Kim-1, P53, TNF-α, Bax, Caspase3) were assessed 60-day experiment. The examination was additionally extended to explore potential protective green-synthesized zinc oxide nanoparticles (ZNO-MONPs). A four-group experiment including control, ZNO-MONPs (10 mg/kg b.wt.), ACR (20 + established encompassing biochemical, histological, molecular levels. further protein-binding ability ZNO MONPs inactivate caspase-3, TNFRS-1A. Results: significantly reduced as evidenced by increased serum creatinine, uric acid, albumin, stress markers. stress, apoptosis, inflammationare revealed biochemical tests, gene expression, presence apoptotic nuclei microscopically. Also, docking binding affinity between ACR-BCL-2 glutathione-synthetase, elucidating mechanisms through which induces damage. Notably, against Zn levels tissues ACR-exposed rats restored those treated with ZNO-MONPs. conclusion, this establishes efficacy mitigating disturbances functions, inflammation, apoptosis. findings shed light renoprotective activity nanomaterials, offering insights into novel therapeutic approaches countering

Language: Английский

Citations

1
The interplay of oxidative stress, apoptotic signaling, and impaired mitochondrial function in the pyrethroid-induced cardiac injury: Alleviative role of curcumin-loaded chitosan nanoparticle DOI
Alaa S. Alhegaili, Duaa Abdullah Bafail,

Ahmed Abdulwahab Bawahab

et al.

Food and Chemical Toxicology, Journal Year: 2024, Volume and Issue: 194, P. 115095 - 115095

Published: Nov. 6, 2024

Language: Английский

Citations

0
The mechanistic pathway induced by fenpropathrin toxicity: Oxidative stress, signaling pathway, and mitochondrial damage DOI
Soliman Mm, Adel F. Tohamy, Abdelbary Prince

et al.

Journal of Biochemical and Molecular Toxicology, Journal Year: 2024, Volume and Issue: 38(11)

Published: Oct. 17, 2024

Abstract Fenpropathrin (FNP) is a kind of insecticide and acaricide known as pyrethroid. It very effective, has wide range activities, works quickly. Internationally, it commonly considered the most powerful pyrethroid insecticide. Nevertheless, an increasing amount data indicates substantial link between adverse effects on nontarget species, including liver toxicity, kidney nerve damage, reproductive toxicity. Oxidative stress plays vital role in toxicity fenpropathrin, addition to its mechanical mechanism. This study offers thorough examination harmful oxidative mitochondrial processes, well signaling pathways involved these effects. The significant impact emphasizes Fenpropathrin.

Language: Английский

Citations

0