Analytical Chemistry,
Год журнала:
2024,
Номер
96(14), С. 5437 - 5445
Опубликована: Март 26, 2024
The
research
on
fluorescent
rotors
for
viscosity
has
attracted
extensive
interest
to
better
comprehend
the
close
relationships
of
microviscosity
variations
with
related
diseases.
Although
scientists
have
made
great
efforts,
probes
cellular
both
aggregation-induced
emissions
(AIEs)
and
large
Stokes
shifts
improve
sensing
properties
rarely
been
reported.
Herein,
we
first
report
four
new
meso-C═N-substituted
BODIPY-based
shifts,
investigate
their
viscosity/AIE
characteristics,
perform
imaging
in
subcellular
organelles.
Interestingly,
meso-C═N-phenyl
group-substituted
probe
6
showed
an
obvious
594
nm
fluorescence
enhancement
glycerol
a
moderate
650
red
AIE
emission
water.
Further,
attaching
CF3
phenyl
group,
similar
phenomenon
was
observed
7
red-shifted
emissions,
attributed
introduction
which
plays
key
role
shifts.
Comparatively,
phenyl-group-free
probes,
meso-C═N-trifluoroethyl
group
thiazole-substituted
(8
9)
exhibited
good
viscosity-responsive
properties,
while
no
due
absence
groups.
For
experiments,
9
lysosomal
mitochondrial
targeting
respectively,
were
further
successfully
used
through
preincubation
monensin
lipopolysaccharide
(LPS),
indicating
that
C═N
polar
groups
potentially
work
as
rotatable
moieties
organelle-targeting
groups,
difference
might
be
ascribed
increased
charges
thiazole.
Therefore,
this
study,
investigated
structural
meso-C═N
respect
subcellular-targeting
ability,
viscosity,
serving
imaging.
