Spermidine‐Functionalized Injectable Hydrogel Reduces Inflammation and Enhances Healing of Acute and Diabetic Wounds In Situ

Advanced Science, Год журнала: 2024, Номер 11(22)

Опубликована: Апрель 11, 2024

Abstract The inflammatory response is a key factor affecting tissue regeneration. Inspired by the immunomodulatory role of spermidine, an injectable double network hydrogel functionalized with spermidine (DN‐SPD) developed, where first and second networks are formed dynamic imine bonds non‐dynamic photo‐crosslinked respectively. single before photo‐crosslinking exhibits excellent injectability thus can be printed in situ to form hydrogels. DN‐SPD has demonstrated desirable mechanical properties adhesion. More importantly, “operando” comparison hydrogels loaded or diethylenetriamine (DETA), sham molecule resembling shown similar physical properties, but quite different biological functions. Specifically, outcomes 3 sets vivo animal experiments demonstrate that not only reduce inflammation caused implanted exogenous biomaterials reactive oxygen species also promote polarization macrophages toward regenerative M2 phenotype, DN‐DETA hydrogel. Moreover, immunoregulation translate into faster more natural healing both acute wounds diabetic wounds. Hence, local administration affords simple elegant approach attenuate foreign body reactions induced treat chronic refractory

Язык: Английский

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The significant role of amino acid metabolic reprogramming in cancer

Cell Communication and Signaling, Год журнала: 2024, Номер 22(1)

Опубликована: Июль 29, 2024

Amino acid metabolism plays a pivotal role in tumor microenvironment, influencing various aspects of cancer progression. The metabolic reprogramming amino acids cells is intricately linked to protein synthesis, nucleotide modulation signaling pathways, regulation cell metabolism, maintenance oxidative stress homeostasis, and epigenetic modifications. Furthermore, the dysregulation also impacts microenvironment immunity. can act as molecules that modulate immune function tolerance within reshaping anti-tumor response promoting evasion by cells. Moreover, influence behavior stromal cells, such cancer-associated fibroblasts, regulate ECM remodeling promote angiogenesis, thereby facilitating growth metastasis. Understanding intricate interplay between crucial significance. Expanding our knowledge multifaceted roles holds significant promise for development more effective therapies aimed at disrupting dependencies modulating enhance responses inhibit

Язык: Английский

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Achieving healthy aging through gut microbiota-directed dietary intervention: Focusing on microbial biomarkers and host mechanisms

Journal of Advanced Research, Год журнала: 2024, Номер unknown

Опубликована: Март 1, 2024

Population aging has become a primary global public health issue, and the prevention of age-associated diseases prolonging healthy life expectancies are particular importance. Gut microbiota emerged as novel target in various host physiological disorders including aging. Comprehensive understanding on changes gut during aging, characteristics centenarians, can provide us possibility to achieving or intervene pathological through microbiota-directed strategies. This review aims summarize associated with explore potential biomarkers address microbiota-associated mechanisms focusing intestinal barrier immune status. By summarizing existing effective dietary strategies interventions, probability developing diet targeting future is provided. focused three key notions: Firstly, new for regulating status lifespan, its closely related age. Thus, we summarized aging-associated features at levels genus/species important metabolites comparing differences among elderly people younger people. Secondly, exploring discussing using regime/components targeted aging-related promote human lifespan. Thirdly, intervention effectively improve imbalance such probiotics, prebiotics, postbiotics, but their effects vary among.

Язык: Английский

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Exploring effects of gut microbiota on tertiary lymphoid structure formation for tumor immunotherapy

Frontiers in Immunology, Год журнала: 2025, Номер 15

Опубликована: Март 7, 2025

Anti-tumor immunity, including innate and adaptive immunity is critical in inhibiting tumorigenesis development of tumor. The needs specific lymph organs such as tertiary lymphoid structures (TLSs), which are highly correlated with improved survival outcomes many cancers. In recent years, increasing attention on the TLS tumor microenvironment, TLSs have emerged a novel target for anti-tumor therapy. Excitingly, studies shown contribution to immune responses. However, it unclear how form more effectively defense against through formation. Recent that inflammation plays role Interestingly, also found gut microbiota can regulate occurrence inflammation. Therefore, we here summarize potential effects microbiota- mediated or immunosuppression formation environments. Meanwhile, this review explores manipulate mature regulating microbiota/metabolites associated signal pathways potentially lead next-generation cancer immunotherapy.

Язык: Английский

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Z-DNA at the crossroads: untangling its role in genome dynamics

Trends in Biochemical Sciences, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

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Harnessing Microalgae as Sustainable Cell Factories for Polyamine-Based Nanosilica for Biomedical Applications

Molecules, Год журнала: 2025, Номер 30(8), С. 1666 - 1666

Опубликована: Апрель 8, 2025

Microalgae are microscopic unicellular organisms that inhabit marine, freshwater, and moist terrestrial ecosystems. The vast number diversity of microalgal species provide a significant reservoir biologically active compounds, highly promising for biomedical applications. Diatoms eukaryotic algae belonging to the class Bacillariophyceae. They possess intricately structured silica-based cell walls, which contain long-chain polyamines play important roles in formation silica. Long-chain uncommon found only produce biosilica. Diatomite, is marine sediment remains silica skeleton diatoms, could be an abundant source biogenic can easily converted particles. This concise review focuses on biofabrication polyamine-based nanosilica from diatoms highlights possibility utilizing diatom biosilica as nanocarrier drug siRNA delivery, bioimaging, bone tissue engineering. challenges may affect production, including environmental stresses climate change, discussed together with prospect increasing diatom-based production desired nanostructures via genetic manipulation.

Язык: Английский

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Polyamine Content of Enteral Nutrition Formulas: Effect of Daily Intake on the Feeding Tolerance of Patients During the First Week in the Intensive Care Unit

Applied Sciences, Год журнала: 2025, Номер 15(2), С. 659 - 659

Опубликована: Янв. 11, 2025

Enteral nutrition (EN) formulas are necessary for critically ill patients to meet their metabolic requirements. Polyamines (putrescine, spermidine, and spermine) crucial dietary components, with spermidine being particularly interesting due its multiple proposed benefits. The requirements intake of polyamines have yet be investigated in adult hospitalised intensive care units (ICUs) who exclusively fed via commercial EN formulas. aim this study was determine the polyamine content other biogenic amines total gastric residual volume (GRV) ICU during first seven days hospitalisation. were analysed 16 using high-performance liquid chromatography (HPLC). clinical data eight both sexes aged 47 77 admitted analysed. Differences existed among N-acetyl putrescine higher than that remaining amines. daily less 100 μmol (the is above 400 μmol). An inverse correlation between GRV, without effects from Polyamine receiving low could impact these patients’ feeding tolerance. These findings underscore need further research explore implications increasing

Язык: Английский

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Cellular senescence: from homeostasis to pathological implications and therapeutic strategies

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Фев. 3, 2025

Cellular aging is a multifactorial and intricately regulated physiological process with profound implications. The interaction between cellular senescence cancer complex multifaceted, can both promote inhibit tumor progression through various mechanisms. M6A methylation modification regulates the of cells tissues by modulating senescence-related genes. In this review, we comprehensively discuss characteristics senescence, signaling pathways regulating biomarkers mechanisms anti-senescence drugs. Notably, review also delves into interactions cancer, emphasizing dual role senescent microenvironment in initiation, progression, treatment. Finally, thoroughly explore function mechanism m6A revealing its critical gene expression maintaining homeostasis. conclusion, provides comprehensive perspective on molecular biological significance offers new insights for development strategies.

Язык: Английский

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Spermidine as a Potential Protective Agents Against Poly(I:C)-Induced Immune Response, Oxidative Stress, Apoptosis, and Testosterone Decrease in Yak Leydig Cells

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(6), С. 2753 - 2753

Опубликована: Март 19, 2025

Viral infections of the reproductive tract and testis in male yaks, often resulting from natural mating under grazing conditions, can lead to infertility due Leydig cell (LC) apoptosis, immune activation, oxidative stress, reduced testosterone production. Spermidine (SPD), a potential therapeutic agent with antioxidant anti-aging properties, might alleviate oxidant response, virus infection caused by apoptosis. In this study, firstly testicular cells yak were induced Poly(I:C), pathogen-associated molecular pattern dsRNA virus, as pathogenic model at cellular level. Secondly, synthesis measured LC or without SPD culture medium. Finally, transcriptomic sequencing was utilized investigate mechanisms underlying protective effects SPD. These results suggested Poly(I:C) damaged function cells, significantly decreased concentration testosterone, while alleviated response then inhibited apoptosis restores production LCs. Transcriptomic analysis revealed that alleviates inflammation reducing damage through regulation several key gene expressions. findings suggest has ability mitigate Poly(I:C)-induced restore offering promising strategy protect enhance fertility after virus.

Язык: Английский

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Spermidine attenuates microglial activation, neuroinflammation, and neuronal injury in rat model of vascular dementia

Neuroscience, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

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