Prognostic, oncogenic roles, and pharmacogenomic features of AMD1 in hepatocellular carcinoma DOI Creative Commons

Youliang Zhou,

Yi Zhou, Jing Hu

et al.

Cancer Cell International, Journal Year: 2024, Volume and Issue: 24(1)

Published: Dec. 18, 2024

AMD1 is the gene encoding S-adenosylmethionine decarboxylase 1. How affects prognosis of hepatocellular carcinoma (HCC) patients unclear. Using Cancer Genome Atlas (TCGA) liver datasets, enrichment and immunological traits were compared between groups with high low expression. After altering expression in HCC cells, cell viability, clonal formation rate, migration invasion ability detected. Univariate Cox regression analysis Pearson correlation used to screen for AMD1-related genes (ARGs). Multidimensional bioinformatic algorithms utilized establish a risk score model ARGs. was notably increased majority cancer types. High associated adverse outcomes poorer immunotherapy response patients. exhibited higher levels lines. The efficient inhibition proliferation, migration, vitro can be achieved through downregulation AMD1. constructed 9 ARGs, demonstrated predictive efficacy multiple validation cohorts. Patients scores greater resistance classical chemotherapy drugs. nomogram, which consists age, stage, score, calculate probability survival each individual. present study indicates that functions as potential role progression may serve therapeutic target HCC. This novel scoring system predicting treatment responsiveness HCC, enabling prediction identification targets.

Language: Английский

Spermidine‐Functionalized Injectable Hydrogel Reduces Inflammation and Enhances Healing of Acute and Diabetic Wounds In Situ DOI Creative Commons
Qianqian Wu,

Runjiao Yang,

Wenxuan Fan

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(22)

Published: April 11, 2024

Abstract The inflammatory response is a key factor affecting tissue regeneration. Inspired by the immunomodulatory role of spermidine, an injectable double network hydrogel functionalized with spermidine (DN‐SPD) developed, where first and second networks are formed dynamic imine bonds non‐dynamic photo‐crosslinked respectively. single before photo‐crosslinking exhibits excellent injectability thus can be printed in situ to form hydrogels. DN‐SPD has demonstrated desirable mechanical properties adhesion. More importantly, “operando” comparison hydrogels loaded or diethylenetriamine (DETA), sham molecule resembling shown similar physical properties, but quite different biological functions. Specifically, outcomes 3 sets vivo animal experiments demonstrate that not only reduce inflammation caused implanted exogenous biomaterials reactive oxygen species also promote polarization macrophages toward regenerative M2 phenotype, DN‐DETA hydrogel. Moreover, immunoregulation translate into faster more natural healing both acute wounds diabetic wounds. Hence, local administration affords simple elegant approach attenuate foreign body reactions induced treat chronic refractory

Language: Английский

Citations

22
Achieving healthy aging through gut microbiota-directed dietary intervention: Focusing on microbial biomarkers and host mechanisms DOI Creative Commons
Yue Xiao,

Yingxuan Feng,

Jianxin Zhao

et al.

Journal of Advanced Research, Journal Year: 2024, Volume and Issue: unknown

Published: March 1, 2024

Population aging has become a primary global public health issue, and the prevention of age-associated diseases prolonging healthy life expectancies are particular importance. Gut microbiota emerged as novel target in various host physiological disorders including aging. Comprehensive understanding on changes gut during aging, characteristics centenarians, can provide us possibility to achieving or intervene pathological through microbiota-directed strategies. This review aims summarize associated with explore potential biomarkers address microbiota-associated mechanisms focusing intestinal barrier immune status. By summarizing existing effective dietary strategies interventions, probability developing diet targeting future is provided. focused three key notions: Firstly, new for regulating status lifespan, its closely related age. Thus, we summarized aging-associated features at levels genus/species important metabolites comparing differences among elderly people younger people. Secondly, exploring discussing using regime/components targeted aging-related promote human lifespan. Thirdly, intervention effectively improve imbalance such probiotics, prebiotics, postbiotics, but their effects vary among.

Language: Английский

Citations

20
The significant role of amino acid metabolic reprogramming in cancer DOI Creative Commons

Xiaohong Liu,

Bo Ren, Jie Ren

et al.

Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)

Published: July 29, 2024

Amino acid metabolism plays a pivotal role in tumor microenvironment, influencing various aspects of cancer progression. The metabolic reprogramming amino acids cells is intricately linked to protein synthesis, nucleotide modulation signaling pathways, regulation cell metabolism, maintenance oxidative stress homeostasis, and epigenetic modifications. Furthermore, the dysregulation also impacts microenvironment immunity. can act as molecules that modulate immune function tolerance within reshaping anti-tumor response promoting evasion by cells. Moreover, influence behavior stromal cells, such cancer-associated fibroblasts, regulate ECM remodeling promote angiogenesis, thereby facilitating growth metastasis. Understanding intricate interplay between crucial significance. Expanding our knowledge multifaceted roles holds significant promise for development more effective therapies aimed at disrupting dependencies modulating enhance responses inhibit

Language: Английский

Citations

20
Exploring effects of gut microbiota on tertiary lymphoid structure formation for tumor immunotherapy DOI Creative Commons
Yuqing Liu,

Fan Li,

Juanjuan Wang

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15

Published: March 7, 2025

Anti-tumor immunity, including innate and adaptive immunity is critical in inhibiting tumorigenesis development of tumor. The needs specific lymph organs such as tertiary lymphoid structures (TLSs), which are highly correlated with improved survival outcomes many cancers. In recent years, increasing attention on the TLS tumor microenvironment, TLSs have emerged a novel target for anti-tumor therapy. Excitingly, studies shown contribution to immune responses. However, it unclear how form more effectively defense against through formation. Recent that inflammation plays role Interestingly, also found gut microbiota can regulate occurrence inflammation. Therefore, we here summarize potential effects microbiota- mediated or immunosuppression formation environments. Meanwhile, this review explores manipulate mature regulating microbiota/metabolites associated signal pathways potentially lead next-generation cancer immunotherapy.

Language: Английский

Citations

2
Z-DNA at the crossroads: untangling its role in genome dynamics DOI

Vinodh J. Sahayasheela,

Mitsuharu Ooga,

Tomotaka Kumagai

et al.

Trends in Biochemical Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

1
Polyamine Content of Enteral Nutrition Formulas: Effect of Daily Intake on the Feeding Tolerance of Patients During the First Week in the Intensive Care Unit DOI Creative Commons
Manuel Sánchez,

Eva Rodríguez-Hernández,

Lorena Suárez

et al.

Applied Sciences, Journal Year: 2025, Volume and Issue: 15(2), P. 659 - 659

Published: Jan. 11, 2025

Enteral nutrition (EN) formulas are necessary for critically ill patients to meet their metabolic requirements. Polyamines (putrescine, spermidine, and spermine) crucial dietary components, with spermidine being particularly interesting due its multiple proposed benefits. The requirements intake of polyamines have yet be investigated in adult hospitalised intensive care units (ICUs) who exclusively fed via commercial EN formulas. aim this study was determine the polyamine content other biogenic amines total gastric residual volume (GRV) ICU during first seven days hospitalisation. were analysed 16 using high-performance liquid chromatography (HPLC). clinical data eight both sexes aged 47 77 admitted analysed. Differences existed among N-acetyl putrescine higher than that remaining amines. daily less 100 μmol (the is above 400 μmol). An inverse correlation between GRV, without effects from Polyamine receiving low could impact these patients’ feeding tolerance. These findings underscore need further research explore implications increasing

Language: Английский

Citations

0
Cellular senescence: from homeostasis to pathological implications and therapeutic strategies DOI Creative Commons
Chunhong Li,

Yixiao Yuan,

YingDong Jia

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 3, 2025

Cellular aging is a multifactorial and intricately regulated physiological process with profound implications. The interaction between cellular senescence cancer complex multifaceted, can both promote inhibit tumor progression through various mechanisms. M6A methylation modification regulates the of cells tissues by modulating senescence-related genes. In this review, we comprehensively discuss characteristics senescence, signaling pathways regulating biomarkers mechanisms anti-senescence drugs. Notably, review also delves into interactions cancer, emphasizing dual role senescent microenvironment in initiation, progression, treatment. Finally, thoroughly explore function mechanism m6A revealing its critical gene expression maintaining homeostasis. conclusion, provides comprehensive perspective on molecular biological significance offers new insights for development strategies.

Language: Английский

Citations

0
Spermidine as a Potential Protective Agents Against Poly(I:C)-Induced Immune Response, Oxidative Stress, Apoptosis, and Testosterone Decrease in Yak Leydig Cells DOI Open Access

Yujun Tang,

Hao Li, Yutian Zeng

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2753 - 2753

Published: March 19, 2025

Viral infections of the reproductive tract and testis in male yaks, often resulting from natural mating under grazing conditions, can lead to infertility due Leydig cell (LC) apoptosis, immune activation, oxidative stress, reduced testosterone production. Spermidine (SPD), a potential therapeutic agent with antioxidant anti-aging properties, might alleviate oxidant response, virus infection caused by apoptosis. In this study, firstly testicular cells yak were induced Poly(I:C), pathogen-associated molecular pattern dsRNA virus, as pathogenic model at cellular level. Secondly, synthesis measured LC or without SPD culture medium. Finally, transcriptomic sequencing was utilized investigate mechanisms underlying protective effects SPD. These results suggested Poly(I:C) damaged function cells, significantly decreased concentration testosterone, while alleviated response then inhibited apoptosis restores production LCs. Transcriptomic analysis revealed that alleviates inflammation reducing damage through regulation several key gene expressions. findings suggest has ability mitigate Poly(I:C)-induced restore offering promising strategy protect enhance fertility after virus.

Language: Английский

Citations

0
Spermidine attenuates microglial activation, neuroinflammation, and neuronal injury in rat model of vascular dementia DOI
Xinyuan Zhao, Dan Li, Zirui Zhu

et al.

Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Insights from Metabolomic and Transcriptomic Analyses into Sulforaphane’s Protective Mechanism Against Deoxynivalenol Toxicity via Spermine Regulation DOI Creative Commons

Yeyi Xiao,

Jianliang Wu, Mei Feng

et al.

Toxins, Journal Year: 2025, Volume and Issue: 17(4), P. 178 - 178

Published: April 3, 2025

Deoxynivalenol (DON) is a mycotoxin ubiquitously present in the environment. Emerging evidence demonstrated that sulforaphane (SFN) exerts potent protective effects against DON-triggered cytotoxicity through multimodal mechanisms. This study aimed to investigate mechanism of SFN during DON exposure. Untargeted metabolomics IPEC-J2 cells revealed total 399 differential metabolites between and control group 365 + group. KEGG enrichment was performed potential regulatory pathways. The transcriptome identified 1839 expression genes (DEGs) groups. result indicated exposure treatment have profound impact on cellular metabolism genes. Integrated analysis metabolome showed spermine biomarker for treatment. increased abundance by regulating glutathione, beta-alanine, arginine proline Functional experiments alleviated DON-induced oxidative stress, as evidenced cell viability, reduced ROS levels, restored mitochondrial membrane (ΔΨm), normalized antioxidant enzyme activity. Moreover, significantly decreased apoptosis rate induced DON, which suggested cytotoxicity. Overall, these findings elucidated role spermine-related mechanisms toxicity DON.

Language: Английский

Citations

0