Journal of Controlled Release,
Год журнала:
2024,
Номер
372, С. 619 - 647
Опубликована: Июнь 29, 2024
In
recent
years,
enzyme
therapy
strategies
have
rapidly
evolved
to
catalyze
essential
biochemical
reactions
with
therapeutic
potential.
These
approaches
hold
particular
promise
in
addressing
rare
genetic
disorders,
cancer
treatment,
neurodegenerative
conditions,
wound
healing,
inflammation
management,
and
infectious
disease
control,
among
others.
There
are
several
primary
reasons
for
the
utilization
of
enzymes
as
therapeutics:
their
substrate
specificity,
biological
compatibility,
ability
generate
a
high
number
product
molecules
per
unit.
features
encouraged
application
replacement
where
serves
agent
rectify
abnormal
metabolic
physiological
processes,
prodrug
initiates
clinical
effect
by
activating
prodrugs,
dynamic
or
starving
acts
upon
host
molecules.
Currently,
there
>20
commercialized
products
based
on
enzymes,
but
approval
rates
considerably
lower
than
other
biologicals.
This
has
stimulated
nanobiotechnology
last
years
develop
nanoparticle-based
solutions
that
integrate
enzymes.
approach
aims
enhance
stability,
prevent
rapid
clearance,
reduce
immunogenicity,
even
enable
spatio-temporal
activation
catalyst.
comprehensive
review
delves
into
emerging
trends
emphasis
synergistic
opportunities
presented
incorporating
nanomaterials.
Such
integration
holds
enhancing
existing
therapies
paving
way
innovative
nanotherapeutic
approaches.
Cells,
Год журнала:
2022,
Номер
11(1), С. 140 - 140
Опубликована: Янв. 2, 2022
Despite
the
numerous
investigations
on
resistance
mechanisms,
drug
in
cancer
therapies
still
limits
favorable
outcomes
patients.
The
complexities
of
inherent
characteristics
tumors,
such
as
tumor
heterogeneity
and
complicated
interaction
within
microenvironment,
hinder
efforts
to
overcome
cells,
requiring
innovative
approaches.
In
this
review,
we
describe
recent
studies
offering
evidence
for
essential
roles
amino
acid
metabolism
driving
cells.
Amino
acids
support
cells
counteracting
by
maintaining
redox
homeostasis,
sustaining
biosynthetic
processes,
regulating
epigenetic
modification,
providing
metabolic
intermediates
energy
generation.
addition,
impacts
anticancer
immune
responses,
creating
an
immunosuppressive
or
immunoeffective
microenvironment.
A
comprehensive
understanding
it
relates
therapeutic
mechanisms
will
improve
strategies.
Theranostics,
Год журнала:
2023,
Номер
13(6), С. 1974 - 2014
Опубликована: Янв. 1, 2023
Chemodynamic
therapy
(CDT)
is
well-known
for
using
the
tumor
microenvironment
to
activate
Fenton
reaction
or
Fenton-like
generate
strong
oxidative
hydroxyl
radicals
tumor-specific
treatment.
It
highly
selective
and
safe,
without
depth
limitation
of
tissue
penetration,
shows
its
potential
as
a
new
green
therapeutic
method
with
great
clinical
application.
However,
catalytic
efficiency
reagents
involved
in
severely
affected
by
inherent
microenvironmental
limitations
tumors
strict
reaction-dependent
conditions.
With
increasing
application
nanotechnology
medical
field,
combined
therapies
based
on
different
types
functional
nanomaterials
have
opened
up
avenues
development
next-generation
CDT-enhanced
system.
This
review
will
comprehensively
exemplify
representative
results
CDT
other
antitumor
such
chemotherapy,
phototherapy,
sonodynamic
therapy,
radiation
magnetic
hyperthermia
immunotherapy,
starvation
gas
gene
oncosis
combination
thereof
improving
from
hundreds
latest
literature,
introduce
strategies
ingenious
design
nanomedicines
regulations
enhance
further
summarize
challenges
future
perspective
CDT-based
multimodal
anticancer
therapy.
Cell Death and Disease,
Год журнала:
2024,
Номер
15(1)
Опубликована: Янв. 13, 2024
Abstract
Amino
acid
metabolism
plays
important
roles
in
tumor
biology
and
therapy.
Accumulating
evidence
has
shown
that
amino
acids
contribute
to
tumorigenesis
immunity
by
acting
as
nutrients,
signaling
molecules,
could
also
regulate
gene
transcription
epigenetic
modification.
Therefore,
targeting
will
provide
new
ideas
for
treatment
become
an
therapeutic
approach
after
surgery,
radiotherapy,
chemotherapy.
In
this
review,
we
systematically
summarize
the
recent
progress
of
malignancy
their
interaction
with
signal
pathways
well
effect
on
microenvironment
Collectively,
highlight
potential
application
future
expectation.
Abstract
KRAS
is
one
of
the
most
mutated
genes,
driving
alternations
in
metabolic
pathways
that
include
enhanced
nutrient
uptaking,
increased
glycolysis,
elevated
glutaminolysis,
and
heightened
synthesis
fatty
acids
nucleotides.
However,
beyond
mechanisms
KRAS-modulated
cancer
metabolisms
remain
incompletely
understood.
In
this
review,
we
aim
to
summarize
current
knowledge
on
KRAS-related
alterations
cells
explore
prevalence
significance
mutation
shaping
tumor
microenvironment
influencing
epigenetic
modification
via
various
molecular
activities.
Given
rely
these
changes
sustain
cell
growth
survival,
targeting
processes
may
represent
a
promising
therapeutic
strategy
for
KRAS-driven
cancers.
TrAC Trends in Analytical Chemistry,
Год журнала:
2023,
Номер
167, С. 117252 - 117252
Опубликована: Авг. 25, 2023
Fluorescent
biosensors
are
powerful
analytical
tools
that
have
been
widely
employed
in
a
range
of
vitro
and
vivo
biomedical
applications.
However,
traditional
fluorophores
exhibit
aggregation-caused
quenching
(ACQs)
effects
hinder
their
use
the
development
more
advanced
fluorescent
biosensors.
The
discovery
by
Prof.
Ben
Zhong
Tang
aggregation-induced
emission
(AIE)
luminogen
(AIEgen)
opposite
to
those
impacted
ACQ
provides
unique
opportunities
for
design
novel
"turn-on"
These
AIEgens
thus
attracted
extensive
interest
from
researchers
seeking
leverage
properties
produce
effective
biosensing
molecules,
strategies,
associated
A
wide
array
with
structures,
functional
groups,
optical
properties,
applications
developed
recent
years.
In
present
review,
we
provide
comprehensive
overview
advances
field
AIEgen-based
biosensor
discuss
future
clinical
prospects
these
molecules.
Through
discussions,
hope
strong
evidence-based
foundation
further
efforts
aimed
at
producing
increasingly
