Pharmaceutics,
Год журнала:
2023,
Номер
15(4), С. 1142 - 1142
Опубликована: Апрель 4, 2023
Alginate
is
a
naturally
derived
polysaccharide
widely
applied
in
drug
delivery,
as
well
regenerative
medicine,
tissue
engineering
and
wound
care.
Due
to
its
excellent
biocompatibility,
low
toxicity,
the
ability
absorb
high
amount
of
exudate,
it
used
modern
dressings.
Numerous
studies
indicate
that
alginate
care
can
be
enhanced
with
incorporation
nanoparticles,
revealing
additional
properties
beneficial
healing
process.
Among
most
extensively
explored
materials,
composite
dressings
loaded
antimicrobial
inorganic
nanoparticles
mentioned.
However,
other
types
antibiotics,
growth
factors,
active
ingredients
are
also
investigated.
This
review
article
focuses
on
recent
findings
regarding
novel
alginate-based
materials
their
applicability
dressings,
special
attention
paid
potential
use
treatment
chronic
wounds.
Advanced Healthcare Materials,
Год журнала:
2020,
Номер
9(5)
Опубликована: Янв. 24, 2020
Abstract
The
accelerating
and
thorough
treatment
of
chronic
wounds
still
represents
a
major
unmet
medical
need
owing
to
the
complex
symptoms
resulting
from
metabolic
disorder
wound
microenvironment.
Although
numerous
strategies
bioactive
hydrogels
are
developed,
an
effective
widely
used
method
remains
bottleneck.
With
aim
accelerate
healing,
many
hydrogel
dressings
with
antioxidant
functions
have
emerged
proven
especially
for
repair.
new
strategy
in
brought
by
is
great
significance
human
health.
Here,
application
repair
discussed
systematically,
aiming
provide
important
theoretical
reference
further
breakthrough
healing.
Frontiers in Pharmacology,
Год журнала:
2018,
Номер
9
Опубликована: Ноя. 2, 2018
Nanomedicines
can
be
used
for
a
variety
of
cancer
therapies
including
tumor-targeted
drug
delivery,
hyperthermia,
and
photodynamic
therapy.
Poly
(lactic-co-glycolic
acid)
(PLGA)-based
materials
are
frequently
in
such
setups.
This
review
article
gives
an
overview
the
properties
previously
reported
PLGA
nanoparticles
(NPs),
their
behavior
biological
systems,
use
Strategies
emphasized
to
target
NPs
tumor
site
passively
actively.
Furthermore,
combination
introduced
that
enhance
accumulation
and,
thereby,
therapeutic
efficacy.
In
this
context,
huge
number
reports
on
as
delivery
systems
treatment
highlight
potential
carriers
therapeutics
encourage
further
translational
research.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2019,
Номер
7
Опубликована: Май 24, 2019
Advances
in
nanoparticle
(NP)
production
and
demand
for
control
over
nanoscale
systems
have
had
significant
impact
on
tissue
engineering
regenerative
medicine
(TERM).
NPs
with
low
toxicity,
contrasting
agent
properties,
tailorable
characteristics,
targeted/stimuli-response
delivery
potential,
precise
behavior
(via
external
stimuli
such
as
magnetic
fields)
made
it
possible
their
use
improving
engineered
tissues
overcoming
obstacles
TERM.
Functional
organ
replacements
require
a
high
degree
of
spatial
temporal
the
biological
events
also
real-time
monitoring.
Presentation
local
bioactive
(growth
factors,
chemokines,
inhibitors,
cytokines,
genes
etc.)
contrast
agents
controlled
manner
are
important
implements
to
exert
monitor
tissues.
This
need
resulted
utilization
NP
based
scaffolds
multiple
growth
providing
imaging
controlling
properties
scaffolds.
Depending
application,
materials,
polymers,
metals,
ceramics
different
composites
can
be
utilized
NPs.
In
this
review,
we
will
cover
TERM
provide
an
outlook
future
potential
systems.
Biomaterials Science,
Год журнала:
2019,
Номер
7(7), С. 2652 - 2674
Опубликована: Янв. 1, 2019
The
emergence
of
inorganic
nanoparticles
has
generated
considerable
expectation
for
solving
various
biomedical
issues
including
wound
healing
and
tissue
regeneration.
This
review
article
highlights
the
role
recent
advancements
regeneration
along
with
their
advantages,
clinical
status,
challenges
future
directions.
Nanoscale,
Год журнала:
2019,
Номер
12(4), С. 2268 - 2291
Опубликована: Дек. 13, 2019
Infections
are
the
main
reason
why
most
people
die
from
burns
and
diabetic
wounds.
The
clinical
challenge
for
treating
wound
infections
through
traditional
antibiotics
has
been
growing
steadily
now
reached
a
critical
status
requiring
paradigm
shift
improved
chronic
care.
US
Centers
Disease
Control
have
predicted
more
deaths
antimicrobial-resistant
bacteria
than
all
types
of
cancers
combined
by
2050.
Thus,
development
new
dressing
materials
that
do
not
rely
on
is
paramount
importance.
Currently,
incorporating
nanoparticles
into
scaffolds
represents
concept
'nanoparticle
dressing'
which
gained
considerable
attention
healing.
Silver
(Ag-NPs)
categorized
as
metal-based
intriguing
healing
because
their
excellent
antimicrobial
properties.
Ag-NPs
embedded
in
polymers
promote
control
microorganism
growth.
However,
there
several
recent
disadvantages
using
to
fight
infections,
such
bacterial
resistance.
This
review
highlights
therapeutic
approaches
dressings
functionalized
with
potential
role
revolutionizing
Moreover,
physiology
skin
wounds
discussed
place
use
care
perspective.
International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(4), С. 2034 - 2034
Опубликована: Фев. 12, 2022
Polymeric
materials
have
been
extensively
explored
in
the
field
of
nanomedicine;
within
them,
poly
lactic-co-glycolic
acid
(PLGA)
holds
a
prominent
position
micro-
and
nanotechnology
due
to
its
biocompatibility
controllable
biodegradability.
In
this
review
we
focus
on
combination
PLGA
with
different
inorganic
nanomaterials
form
nanocomposites
overcome
polymer’s
limitations
extend
applications.
We
discuss
their
physicochemical
properties
variety
well-established
synthesis
methods
for
preparation
PLGA-based
materials.
Recent
progress
design
biomedical
applications
are
thoroughly
discussed
provide
framework
future
research.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2020,
Номер
8
Опубликована: Фев. 11, 2020
Polymeric
biomaterials
have
found
widespread
applications
in
nanomedicine,
and
PLGA
particular
has
been
successfully
implemented
numerous
drug
delivery
formulations
due
to
its
synthetic
malleability
biocompatibility.
However,
the
need
for
preconception
these
is
increasing,
this
can
be
achieved
by
selection
elimination
of
design
variables
order
systems
tailored
their
specific
applications.
The
starting
materials
preparation
methods
shown
influence
various
parameters
PLGA-based
nanocarriers
implementation
systems,
while
computational
simulations
as
a
component
formulation
studies
provide
valuable
information
on
characteristics.
This
review
provides
critical
summary
synthesis
bio-medicine
outlines
experimental
considerations
systems.
ACS Biomaterials Science & Engineering,
Год журнала:
2020,
Номер
6(10), С. 5399 - 5430
Опубликована: Авг. 25, 2020
The
morbidity,
mortality,
and
burden
of
burn
victims
patients
with
severe
diabetic
wounds
are
still
high,
which
leads
to
an
extensively
growing
demand
for
novel
treatments
high
clinical
efficacy.
Biomaterial-based
wound
treatment
approaches
have
progressed
over
time
from
simple
cotton
wool
dressings
advanced
skin
substitutes
containing
cells
growth
factors;
however,
no
care
approach
is
yet
completely
satisfying.
Bioactive
glasses
materials
potential
in
many
areas
that
exhibit
unique
features
biomedical
applications.
Today,
bioactive
not
only
amorphous
solid
structures
can
be
used
as
a
substitute
hard
tissue
but
also
promising
soft
regeneration
healing
Biologically
active
elements
such
Ag,
B,
Ca,
Ce,
Co,
Cu,
Ga,
Mg,
Se,
Sr,
Zn
incorporated
glass
networks;
hence,
the
superiority
these
multifunctional
current
results
their
ability
release
multiple
therapeutic
ions
environment,
target
different
stages
process.
dissolution
products
potency
inducing
angiogenesis
exerting
several
biological
impacts
on
cell
functions,
involved
some
other
valuable
applications,
namely
hemostatic
antibacterial
properties.
In
this
review,
we
focus
structure,
dynamic
process
injured
skin,
existing
approaches.
basic
concepts
reviewed
better
understand
relationship
between
structure
its
We
illustrate
role
repair
regeneration.
Finally,
research
studies
applications
summarized
future
trends
field
elaborated.
