ACS Nano,
Год журнала:
2024,
Номер
18(43), С. 29492 - 29506
Опубликована: Окт. 18, 2024
Magnetic
nanorobots
are
emerging
players
in
thrombolytic
therapy
due
to
their
noninvasive
remote
actuation
and
drug
loading
capabilities.
Although
the
with
a
size
under
100
nm
ideal
apply
microvascular
systems,
propulsion
performance
of
is
inevitably
compromised
limited
response
magnetic
fields.
Here,
we
demonstrate
nattokinase-loaded
vortex
nanorobot
(NK-MNR)
an
average
around
70
high
saturation
magnetization
for
mechanical
propelling
thermal
responsive
thrombolysis
field
dual
frequencies.
The
stable
suspension
undergo
magneto-steered
assembly
into
chain-like
NK-MNRs,
which
regulated
generate
forces
mechanically
damage
penetrate
thrombus
by
low-frequency
rotating
field.
Synergistically,
enhanced
hyperthermia
triggered
alternating
frequency,
enabling
heat-induced
NK
release
fibrinolysis.
In
this
frequency-regulated
magnetothrombolysis
(fRMT)
strategy,
collaborate
energy
conversion
model
achieve
vasculature
recanalization
rate
81.0%
thrombotic
mice.
Overall,
special
property
multimodel
controls
promising
nanoplatform
vivo
focalized
thrombolysis.
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Янв. 8, 2024
Abstract
The
iron
oxide
nanoparticles
(IONPs),
possessing
both
magnetic
behavior
and
semiconductor
property,
have
been
extensively
used
in
multifunctional
biomedical
fields
due
to
their
biocompatible,
biodegradable
low
toxicity,
such
as
anticancer,
antibacterial,
cell
labelling
activities.
Nevertheless,
there
are
few
IONPs
clinical
use
at
present.
Some
approved
for
withdrawn
insufficient
understanding
of
its
applications.
Therefore,
a
systematic
summary
IONPs’
preparation
applications
is
crucial
the
next
step
entering
practice
from
experimental
stage.
This
review
summarized
existing
research
past
decade
on
biological
interaction
with
animal/cells
models,
human.
aims
provide
cutting-edge
knowledge
involved
effects
vivo
vitro,
improve
smarter
design
application
clinic
trials.
Graphical
Abstract
Atherosclerosis,
a
multifaceted
chronic
inflammatory
disease,
has
profound
impact
on
cardiovascular
health.
However,
the
critical
limitations
of
atherosclerosis
management
include
delayed
detection
advanced
stages,
intricate
assessment
plaque
stability,
and
absence
efficacious
therapeutic
strategies.
Nanotheranostic
based
nanotechnology
offers
novel
paradigm
for
addressing
these
challenges
by
amalgamating
imaging
capabilities
with
targeted
interventions.
Meanwhile,
iron
oxide
nanoparticles
have
emerged
as
compelling
candidates
theranostic
applications
in
due
to
their
magnetic
resonance
capability
biosafety.
This
review
delineates
current
state
prospects
nanoparticle‐based
nanotheranostics
realm
atherosclerosis,
including
pivotal
aspects
development,
pertinent
targeting
strategies
involved
disease
pathogenesis,
diagnostic
roles
nanoparticles.
Furthermore,
this
provides
comprehensive
overview
nanomedicine
approaches
employing
nanoparticles,
encompassing
chemical
therapy,
physical
stimulation
biological
therapy.
Finally,
proposes
discusses
associated
translating
innovative
into
clinically
viable
anti‐atherosclerosis
In
conclusion,
new
insights
future
theranostic,
showcasing
remarkable
potential
oxide‐based
versatile
tools
battle
against
atherosclerosis.
Journal of Drug Delivery Science and Technology,
Год журнала:
2024,
Номер
96, С. 105689 - 105689
Опубликована: Апрель 21, 2024
In
the
last
few
years,
wound
healing
and
development
of
"ideal"
biomaterials
that
provide
quick
recovery
minimize
scarring
have
represented
one
most
important
priorities
researchers.
this
direction,
silk
fibroin
(SF)
scaffolds
gained
substantial
awareness,
as
a
promising
polymer
owing
to
their
increased
biocompatibility,
outstanding
mechanical
properties,
biodegradability,
especially
tensile
strength.
Furthermore,
SF
is
acknowledged
accelerate
process
by
encouraging
cell
growth
proliferation,
also
migration
different
types
cells
are
included
in
stages
process.
Therefore,
metal
oxide
nanoparticles
(NPs),
such
iron
(FeO),
copper
(CuO),
zinc
(ZnO),
or
magnesium
(MgO)
NPs,
been
extensively
researched
for
antimicrobial
properties
ability
enhance
tissue
regeneration
addition
SF.
When
introduced
within
scaffolds,
these
NPs
impart
enhanced
including
improved
scaffold
stability
durability.
Moreover,
presence
could
increase
biocompatibility
facilitating
adhesion,
migration,
ultimately
promoting
processes.
The
incorporation
other
natural
polymers
into
has
thus
emerged
favorable
method
therapeutic
potential
developed
biomaterial.
This
review
aims
an
overview
advancements
containing
applications.
Journal of Functional Biomaterials,
Год журнала:
2024,
Номер
15(8), С. 227 - 227
Опубликована: Авг. 14, 2024
A
wide
range
of
applications
using
functionalized
magnetic
nanoparticles
(MNPs)
in
biomedical
applications,
such
as
biomedicine
well
biotechnology,
have
been
extensively
expanding
over
the
last
years.
Their
potential
is
tremendous
delivery
and
targeting
systems
due
to
their
advantages
biosubstance
binding.
By
applying
materials-based
biomaterials
different
organic
polymers,
highly
advanced
multifunctional
bio-composites
with
high
specificity,
efficiency,
optimal
bioavailability
are
designed
implemented
various
bio-applications.
In
modern
drug
delivery,
importance
a
successful
therapy
depends
on
proper
loaded
bioactive
components
specific
sites
body.
MNPs
nanocarrier-based
that
magnetically
guided
regions
an
external
field.
Therefore,
excellent
tool
for
form
imaging
agents,
sensors,
targets/vehicles,
diagnostic
tools
managing
disease
therapy.
great
contribution
was
made
improve
engineering
skills
surgical
diagnosis,
therapy,
treatment,
while
applicability
opened
up
large
scope
studies.
This
review
highlights
synthesis
strategies,
followed
by
surface
functionalization
techniques,
which
makes
them
promising
biomedicine,
special
emphasis
delivery.
Mechanism
system
key
factors
affecting
efficiency
discussed,
considering
toxicity
limitations
well.
Materials Today Bio,
Год журнала:
2024,
Номер
26, С. 101027 - 101027
Опубликована: Март 16, 2024
Multimodal
imaging,
which
combines
the
strengths
of
two
or
more
imaging
modalities
to
provide
complementary
anatomical
and
molecular
information,
has
emerged
as
a
robust
technology
for
enhancing
diagnostic
sensitivity
accuracy,
well
improving
treatment
monitoring.
Moreover,
application
multimodal
in
guiding
precision
tumor
can
prevent
under-
over-treatment,
thereby
maximizing
benefits
patients.
In
recent
years,
several
intriguing
magneto-optical
nanosystems
with
both
magnetic
optical
properties
have
been
developed,
leading
significant
breakthroughs
field
image-guided
therapy.
These
advancements
pave
way
precise
medicine.
This
review
summarizes
various
types
developed
recently
describes
their
applications
probes
agents
therapeutic
interventions.
Finally,
future
research
development
prospects
are
discussed
along
an
outlook
on
further
biomedical
field.
Journal of Nanotheranostics,
Год журнала:
2025,
Номер
6(2), С. 9 - 9
Опубликована: Март 23, 2025
Antibiotic
resistance
poses
a
significant
global
health
challenge,
undermining
the
effectiveness
of
conventional
treatments
and
increasing
mortality
rates
worldwide.
Factors
such
as
overuse
misuse
antibiotics
in
healthcare
agriculture,
along
with
poor
infection
control
practices,
have
accelerated
emergence
resistant
bacterial
strains.
The
stagnation
development
new
antibiotics,
compounded
by
economic
biological
challenges,
has
necessitated
alternative
approaches
to
combat
infections.
Nanotechnology
provides
promising
solution
using
nanoparticles
(NPs),
which
bacteria
through
mechanisms
like
membrane
disruption
reactive
oxygen
species
(ROS)
generation.
Metal-based
silver
zinc
oxide
possess
intrinsic
antimicrobial
properties,
while
polymer-
carbon-based
enhance
drug
delivery
biofilm
penetration.
Unlike
operate
multi-mechanistic
pathways,
reducing
likelihood
improving
treatment
efficacy.
This
review
aims
provide
an
updated,
in-depth
look
at
recent
advances
nanoparticle
research
targeting
antibiotic
resistance,
discussing
different
types
nanoparticles,
action,
current
challenges
opportunities.
By
exploring
evolving
role
nanotechnology
addressing
this
crisis,
intends
highlight
potential
for
transform
landscape
infections
inspire
further
into
these
innovative
solutions.
