Biomedicine & Pharmacotherapy,
Год журнала:
2023,
Номер
170, С. 115847 - 115847
Опубликована: Ноя. 27, 2023
Ischemic
stroke
is
one
of
the
most
cases
worldwide,
with
high
rate
morbidity
and
mortality.
In
pathological
process
ischemic
stroke,
neuroinflammation
an
essential
that
defines
functional
prognosis.
After
onset,
microglia,
astrocytes
infiltrating
immune
cells
contribute
to
a
complicated
cascade
play
roles
in
pathophysiological
variations
stroke.
Both
microglia
undergo
both
morphological
changes,
thereby
deeply
participate
neuronal
inflammation
via
releasing
pro-inflammatory
or
anti-inflammatory
factors.
Flavonoids
are
plant-specific
secondary
metabolites
can
protect
against
cerebral
ischemia
injury
modulating
inflammatory
responses.
For
instances,
quercetin
inhibit
expression
release
cytokines,
such
as
tumor
necrosis
factor
(TNF)-α,
IL-6
IL-1β,
nervous
system
(CNS).
Apigenin
rutin
promote
polarization
genotype
then
neuroinflammation.
this
review,
we
focused
on
dual
activated
reactive
astrocyte
following
discussed
anti-neuroinflammation
some
flavonoids.
Importantly,
aimed
reveal
new
strategies
for
alleviating
International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
24(1), С. 340 - 340
Опубликована: Дек. 25, 2022
(‒)-Epigallocatechin-3-gallate
(EGCG)
is
the
most
abundant
polyphenol
in
green
tea.
Thanks
to
multiple
interactions
with
cell
surface
receptors,
intracellular
signaling
pathways,
and
nuclear
transcription
factors,
EGCG
possesses
a
wide
variety
of
anti-inflammatory,
antioxidant,
antifibrotic,
anti-remodelation,
tissue-protective
properties
which
may
be
useful
treatment
various
diseases,
particularly
cancer,
neurological,
cardiovascular,
respiratory,
metabolic
disorders.
This
article
reviews
current
information
on
biological
effects
above-mentioned
disorders
relation
molecular
pathways
controlling
inflammation,
oxidative
stress,
apoptosis.
Signal Transduction and Targeted Therapy,
Год журнала:
2022,
Номер
7(1)
Опубликована: Дек. 5, 2022
Abstract
The
outbreak
of
COVID-19
has
become
a
global
crisis,
and
brought
severe
disruptions
to
societies
economies.
Until
now,
effective
therapeutics
against
are
in
high
demand.
Along
with
our
improved
understanding
the
structure,
function,
pathogenic
process
SARS-CoV-2,
many
small
molecules
potential
anti-COVID-19
effects
have
been
developed.
So
far,
several
antiviral
strategies
were
explored.
Besides
directly
inhibition
viral
proteins
such
as
RdRp
M
pro
,
interference
host
enzymes
including
ACE2
proteases,
blocking
relevant
immunoregulatory
pathways
represented
by
JAK/STAT,
BTK,
NF-κB,
NLRP3
pathways,
regarded
feasible
drug
development.
development
treat
achieved
strategies,
computer-aided
lead
compound
design
screening,
natural
product
discovery,
repurposing,
combination
therapy.
Several
representative
remdesivir
paxlovid
proved
or
authorized
emergency
use
countries.
And
candidates
entered
clinical-trial
stage.
Nevertheless,
due
epidemiological
features
variability
issues
it
is
necessary
continue
exploring
novel
COVID-19.
This
review
discusses
current
findings
for
treatment.
Moreover,
their
detailed
mechanism
action,
chemical
structures,
preclinical
clinical
efficacies
discussed.
Journal of Food Biochemistry,
Год журнала:
2022,
Номер
46(8)
Опубликована: Апрель 26, 2022
Epigallocatechin
gallate
(EGCG),
a
green
tea
catechin,
has
gained
the
attention
of
current
study
due
to
its
excellent
health-promoting
effects.
It
possesses
anti-obesity,
antimicrobial,
anticancer,
anti-inflammatory
activities,
and
is
under
extensive
investigation
in
functional
foods
for
improvement.
susceptible
lower
stability,
lesser
bioavailability,
absorption
rate
various
environmental,
processing,
formulations,
gastrointestinal
conditions
human
body.
Therefore,
it
foremost
concern
researchers
enhance
bioactivity
make
most
suitable
therapeutic
compound
clinical
applications.
In
review,
factors
affecting
bioavailability
EGCG
possible
strategies
overcome
these
issues
are
reviewed
discussed.
This
review
summarizes
structural
modifications
delivery
through
nanoparticle-based
approaches
including
nano-emulsions,
encapsulations,
silica-based
nanoparticles
effective
use
foods.
Moreover,
recent
advances
efficacy
by
specifically
targeting
molecules
increase
stability
also
described.
PRACTICAL
APPLICATIONS:
The
main
constituent
several
effects
making
potential
cure
ailments.
However,
low
render
uses
many
disorders.
Synthesizing
prodrugs
helps
against
overcoming
premature
degradation
rate.
paper
that
benefit
different
physiological
conditions.
esterification,
nanoparticle
approaches,
EGCG-NPs,
formulations
serve
as
ideal
modification
deliver
superior
concentrations
with
toxicity
efficient
penetration
across
cells
both
vitro
vivo.
As
result
modifications,
bioactivities
would
be
highly
improved
at
doses.
protected
or
modified
molecule
have
enhanced
contribute
applications
expand
food
cosmetic
industries.
Advanced Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 3, 2025
Abstract
Synthesizing
high
drug‐loading
nanomedicines
remains
a
formidable
challenge,
and
achieving
universally
applicable,
continuous,
large‐scale
engineered
production
of
such
presents
even
greater
difficulties.
This
study
scalable
library
polyphenol‐amino
acid
condensates.
By
selecting
amino
acids,
the
enables
precise
customization
key
properties,
as
carrier
capacity,
bioactivity,
other
critical
attributes,
offering
versatile
range
options
for
various
application
scenarios.
Leveraging
properties
solvent‐mediated
disassembly
reassembly
condensates
achieved
an
ultra‐high
drug
loading
86%
paclitaxel.
For
poorly
soluble
molecules,
capacity
exceeded
50%,
indicating
broad
applicability.
Furthermore,
employing
continuous
microfluidic
device,
rate
can
reach
5
mL
min
−1
(36
g
per
day),
with
nanoparticle
size
precisely
tunable
polydispersity
index
(PDI)
below
0.2.
The
polyphenol‐based
demonstrates
efficient
cellular
uptake
and,
in
three
distinct
animal
models,
has
been
shown
to
enhance
therapeutic
efficacy
paclitaxel
without
significant
side
effects.
streamlined,
efficient,
approach
using
microfluidics
produce
loading,
promising
strategy
nanoformulation
drugs.
Antioxidants,
Год журнала:
2022,
Номер
11(8), С. 1566 - 1566
Опубликована: Авг. 13, 2022
(-)-Epigallocatechin-3-gallate
(EGCG)
is
a
major
polyphenol
of
green
tea
that
possesses
wide
variety
actions.
EGCG
acts
as
strong
antioxidant
which
effectively
scavenges
reactive
oxygen
species
(ROS),
inhibits
pro-oxidant
enzymes
including
NADPH
oxidase,
activates
systems
superoxide
dismutase,
catalase,
or
glutathione,
and
reduces
abundant
production
nitric
oxide
metabolites
by
inducible
synthase.
ECGC
also
exerts
potent
anti-inflammatory,
anti-fibrotic,
pro-apoptotic,
anti-tumorous,
metabolic
effects
via
modulation
intracellular
signaling
cascades.
Based
on
this
knowledge,
the
use
could
be
benefit
in
respiratory
diseases
with
acute
chronic
inflammatory,
oxidative,
fibrotizing
processes
their
pathogenesis.
This
article
reviews
current
information
biological
those
animal
models
has
been
administered,
i.e.,
distress
syndrome,
infections,
COVID-19,
bronchial
asthma,
obstructive
pulmonary
disease,
lung
fibrosis,
silicosis,
cancer,
hypertension,
embolism,
critically
discusses
effectiveness
administration
these
disorders.
For
review,
articles
English
language
from
PubMed
database
were
used.
Critical Reviews in Food Science and Nutrition,
Год журнала:
2022,
Номер
63(30), С. 10382 - 10411
Опубликована: Май 2, 2022
Natural
products
have
been
a
bedrock
for
drug
discovery
decades.
(−)-Epigallocatechin-3-gallate
(EGCG)
is
one
of
the
widely
studied
natural
polyphenolic
compounds
derived
from
green
tea.
It
key
component
believed
to
be
responsible
medicinal
value
Significant
studies
implemented
in
vitro,
cellulo,
and
vivo
models
suggested
its
anti-oxidant,
anti-cancer,
anti-diabetic,
anti-inflammatory,
anti-microbial,
neuroprotective
activities
etc.
Despite
having
such
wide
array
therapeutic
potential
promising
results
preclinical
studies,
applicability
humans
has
encountered
with
rather
limited
success
largely
due
poor
bioavailability,
membrane
permeability,
rapid
metabolic
clearance
lack
stability
EGCG.
Therefore,
novel
techniques
are
warranted
address
those
limitations
so
that
EGCG
or
modified
analogs
can
used
clinical
setup.
This
review
comprehensively
covers
different
strategies
as
structural
modifications,
nano-carriers
efficient
delivery
systems,
synergistic
other
bioactivities
improve
chemico-biological
aspects
(e.g.,
stability,
etc.)
enhanced
pharmacokinetics
pharmacological
properties,
eventually
enhancing
potentials.
We
think
this
article
will
serve
strong
platform
comprehensive
literature
on
development
bioavailability
it
translated
applications.
Cell Proliferation,
Год журнала:
2022,
Номер
55(10)
Опубликована: Июль 5, 2022
3D-printing
scaffold
with
specifically
customized
and
biomimetic
structures
gained
significant
recent
attention
in
tissue
engineering
for
the
regeneration
of
damaged
bone
tissues.
However,
constructed
scaffolds
that
simultaneously
promote
situ
inhibit
bacterial
proliferation
remains
a
great
challenge.
This
study
aimed
to
design
repair
antibacterial
functions.Herein,
general
strategy
is
developed
by
using
epigallocatechin-3-gallate
(EGCG),
major
green
tea
polyphenol,
firmly
anchored
nano-hydroxyapatite
(HA)
coating
3D
printed
polymerization
caprolactone
lactide
(PCLA)
scaffold.
Then,
we
evaluated
stability,
mechanical
properties,
water
absorption,
biocompatibility,
vitro
osteocyte
inductive
ability
scaffolds.The
coated
exhibit
excellent
activity
stimulating
osteogenic
differentiation
resisting
methicillin-resistant
Staphylococcus
aureus
colonization
environment
without
antibiotics.
Meanwhile,
prepared
has
certain
properties
(39.3
±
3.2
MPa),
applied
provides
remarkable
cell
adhesion
conductivity.This
demonstrates
EGCG
self-assembled
HA
on
PCLA
surface
could
effectively
enhance
scaffold's
induction,
situ.
It
new
construct
superior
performance
combat
postoperative
infection
