Prophylactic Effects of Purple Shoot Green Tea on Cytokine Immunomodulation through Scavenging Free Radicals and NO in LPS-Stimulated Macrophages DOI Creative Commons
Chih‐Cheng Lin,

Hsiu-Hua Lin,

Hsiang Chang

и другие.

Current Issues in Molecular Biology, Год журнала: 2022, Номер 44(9), С. 3980 - 4000

Опубликована: Сен. 2, 2022

Polyphenols and flavonoids from non-fermented green tea fully-fermented black exhibit antioxidant abilities that function as natural health foods for daily consumption. Nonetheless, evidence regarding prophylactic effects of purple shoot on immunomodulation remains scarce. We compared the immunomodulatory different processes oxidative stress cytokine expressions in lipopolysaccharide (LPS)-stimulated macrophages. Major constituents four products, Taiwan Tea Experiment Station No.12 (TTES No. 12) (TB, TG, PB PG, respectively), were analyzed to explore free radicals, nitric oxide (NO), monocyte chemoattractant protein-1 (MCP-1), interleukin 6 (IL-6) tumor necrosis factor α (TNF-α) LPS-activated RAW264.7 cell models. PG contained abundant levels total polyphenols, flavonoids, condensed tannins proanthocyanidins (371.28 ± 3.83; 86.37 1.46; 234.67 10.1; 24.81 0.75 mg/g, respectively) contributing excellent radical scavenging potency. In both inflammation model model, all extracts suppressed NO secretion a dose-dependent manner, especially PG. Intriguingly, most enhanced IL-6 LPS-stimulated macrophages, except However, teas disrupted downstream transduction MCP-1 immune trafficking. inhibited inflammatory responses by attenuating TNF-α TG Our demonstrated exerts robust modulating LPS-induced MCP-1, through radicals NO. light LPS-related inflammation, effectively scavenges modulate cascades could serve functional beverage immunomodulation.

Язык: Английский

Therapeutic Effects of Green Tea Polyphenol (‒)-Epigallocatechin-3-Gallate (EGCG) in Relation to Molecular Pathways Controlling Inflammation, Oxidative Stress, and Apoptosis DOI Open Access
Daniela Mokrá, Marta Jošková, Juraj Mokrý

и другие.

International Journal of Molecular Sciences, Год журнала: 2022, Номер 24(1), С. 340 - 340

Опубликована: Дек. 25, 2022

(‒)-Epigallocatechin-3-gallate (EGCG) is the most abundant polyphenol in green tea. Thanks to multiple interactions with cell surface receptors, intracellular signaling pathways, and nuclear transcription factors, EGCG possesses a wide variety of anti-inflammatory, antioxidant, antifibrotic, anti-remodelation, tissue-protective properties which may be useful treatment various diseases, particularly cancer, neurological, cardiovascular, respiratory, metabolic disorders. This article reviews current information on biological effects above-mentioned disorders relation molecular pathways controlling inflammation, oxidative stress, apoptosis.

Язык: Английский

Процитировано

120
Reactive oxygen species and ovarian diseases: Antioxidant strategies DOI Creative Commons

Junzhi Liang,

Yingzhuo Gao,

Ziyi Feng

и другие.

Redox Biology, Год журнала: 2023, Номер 62, С. 102659 - 102659

Опубликована: Март 7, 2023

Reactive oxygen species (ROS) are mainly produced in mitochondria and involved various physiological activities of the ovary through signaling critical for regulating ovarian cycle. Notably, imbalance between ROS generation antioxidant defense system contributes to development diseases. These contradictory effects have implications potential strategies that aim scavenge excessive ROS. However, much remains be learned about how causes diseases application therapy Here, we review mechanisms maintenance homeostasis its associated effects. Additionally, highlighted pathological treatment.

Язык: Английский

Процитировано

64
Epigallocatechin-3-Gallate Therapeutic Potential in Cancer: Mechanism of Action and Clinical Implications DOI Creative Commons
Mateusz Kciuk, Manzar Alam, Nemat Ali

и другие.

Molecules, Год журнала: 2023, Номер 28(13), С. 5246 - 5246

Опубликована: Июль 6, 2023

Cellular signaling pathways involved in the maintenance of equilibrium between cell proliferation and apoptosis have emerged as rational targets that can be exploited prevention treatment cancer. Epigallocatechin-3-gallate (EGCG) is most abundant phenolic compound found green tea. It has been shown to regulate multiple crucial cellular pathways, including those mediated by EGFR, JAK-STAT, MAPKs, NF-κB, PI3K-AKT-mTOR, others. Deregulation abovementioned pathophysiology demonstrated EGCG may exert anti-proliferative, anti-inflammatory, apoptosis-inducing effects or induce epigenetic changes. Furthermore, preclinical clinical studies suggest used numerous disorders, This review aims summarize existing knowledge regarding biological properties EGCG, especially context cancer prophylaxis.

Язык: Английский

Процитировано

41
Natural dietary ROS scavenger-based nanomaterials for ROS-related chronic disease prevention and treatment DOI

Jiani Xie,

Rutuan Dong,

Tairan Zhang

и другие.

Chemical Engineering Journal, Год журнала: 2024, Номер 490, С. 151756 - 151756

Опубликована: Апрель 30, 2024

Язык: Английский

Процитировано

17
Targeting natural antioxidant polyphenols to protect neuroinflammation and neurodegenerative diseases: a comprehensive review DOI Creative Commons
Maroua Jalouli, Md. Ataur Rahman, Partha Biswas

и другие.

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Янв. 24, 2025

Polyphenols, naturally occurring phytonutrients found in plant-based foods, have attracted significant attention for their potential therapeutic effects neurological diseases and neuroinflammation. These compounds possess diverse neuroprotective capabilities, including antioxidant, anti-inflammatory, anti-amyloid properties, which contribute to mitigating the progression of neurodegenerative conditions such as Alzheimer's Disease (AD), Parkinson's (PD), Dementia, Multiple Sclerosis (MS), Stroke, Huntington's (HD). Polyphenols been extensively studied ability regulate inflammatory responses by modulating activity pro-inflammatory genes influencing signal transduction pathways, thereby reducing neuroinflammation neuronal death. Additionally, polyphenols shown promise various cellular signaling pathways associated with viability, synaptic plasticity, cognitive function. Epidemiological clinical studies highlight polyphenol-rich diets decrease risk alleviate symptoms disorders Furthermore, demonstrated through regulation key Akt, Nrf2, STAT, MAPK, play critical roles neuroprotection body's immune response. This review emphasizes growing body evidence supporting combating neurodegeneration neuroinflammation, well enhancing brain health. Despite substantial promising hypotheses, further research investigations are necessary fully understand role establish them advanced targets age-related neuroinflammatory conditions.

Язык: Английский

Процитировано

3
EGCG-NPs inhibition HO-1-mediated reprogram iron metabolism against ferroptosis after subarachnoid hemorrhage DOI Creative Commons

Liyong Huang,

Xue Wang, Yanning Zheng

и другие.

Redox Biology, Год журнала: 2024, Номер 70, С. 103075 - 103075

Опубликована: Фев. 11, 2024

Subarachnoid hemorrhage (SAH), a devastating disease with high mortality rate and poor outcomes, tightly associated the dysregulation of iron metabolism ferroptosis. (−)-Epigallocatechin-3-gallate (EGCG) is one major bioactive compounds tea catechin because its well-known iron-chelating antioxidative activities. However, findings iron-induced cell injuries after SAH remain controversial underlying therapeutic mechanisms EGCG in ferroptosis limited. Here, ability to inhibit death following alleviation neurological function deficits was investigated by using vivo models. As expected, inhibited oxyhemoglobin (OxyHb)-induced over-expression HO-1, which mainly distributed astrocytes microglial cells. Subsequently, blocked ferrous accumulation through HO-1-mediated metabolic reprogramming. Therefore, oxidative stress mitochondrial dysfunction rescued EGCG, resulted downregulation ferritinophagy rather than apoptosis SAH. result, exerted superior effects maintenance homeostasis glial cells, such as well improvement functional outcomes These highlighted that cells were not only iron-rich brain but also susceptible The detrimental role can be regarded an effective target prevention treatment

Язык: Английский

Процитировано

9
Phenolic-rich fraction of green tea attenuates histamine-mediated cardiopulmonary toxicity by inhibiting Cox-2/NF-κB signaling pathway and regulating oxidant/antioxidant balance DOI Creative Commons
Eman I. Hassanen,

Shaimaa Kamel,

Marwa Y. Issa

и другие.

Beni-Suef University Journal of Basic and Applied Sciences, Год журнала: 2024, Номер 13(1)

Опубликована: Янв. 12, 2024

Abstract Background Histamine (HIS) has a substantial impact on the development of numerous allergic disorders including asthma. Antihistamines mostly target histamine receptor-1 alone, so it is not entirely effective in treatment diseases. In current investigation, we examine growing evidence for novel therapeutic strategies that aim to treat histamine-mediated cardiopulmonary toxicity with phenolic-rich fraction green tea (PRFGT). Results Our findings demonstrated weekly ingestion HIS rats induced oxidant/antioxidant imbalance both lung and heart homogenates. The histopathological examination extensive interstitial pneumonia progressive alveolar bronchial damage receiving groups. Heart sections showed severe myocardial necrosis hemorrhage. All lesions were confirmed by immunohistochemical staining strong caspase-3, cyclooxygenase-2 (Cox-2), tumor factor-α (TNF-α) protein expressions along upregulation pulmonary m-RNA expression TNF-α, nuclear factor kappa-B (NF-κB), interleukin-1β (IL-1β) genes cardiac levels many apoptotic genes. Otherwise, pretreatment PRFGT had ability alleviate all aforementioned toxicological parameters return microscopic picture normal histology. Conclusions We concluded PRFGT’s powerful antioxidant, anti-inflammatory, anti-apoptotic properties can reduce caused HIS. recommended daily intake as beverage or adding foods containing elevated prevent its possible toxicity.

Язык: Английский

Процитировано

8
Green Tea in Reproductive Cancers: Could Treatment Be as Simple? DOI Open Access
Maclaine Parish, Gaelle Massoud, Dana Hazimeh

и другие.

Cancers, Год журнала: 2023, Номер 15(3), С. 862 - 862

Опубликована: Янв. 30, 2023

Green tea originates from the plant Camellia sinensis and is one of most widely consumed beverages worldwide. polyphenols, commonly known as catechins, are major bioactive ingredients account for green tea’s unique health benefits. Epigallocatechin-3-gallate (EGCG), potent catechin derivative has been studied its pro- anti-oxidative effects. This review summarizes chemical chemopreventive properties in context female reproductive cancers. A comprehensive search PubMed Google Scholar up to December 2022 was conducted. All original articles related or EGCG, gynecological cancers published English were included. The findings several vitro, vivo, epidemiological studies examining effect on cancers, including ovarian, cervical, endometrial, vulvar presented. Studies have shown that this compound targets specific receptors intracellular signaling pathways involved cancer pathogenesis. potential benefits using treatment alone conjunction with chemotherapeutic agents, examined, shedding light new therapeutic strategies management

Язык: Английский

Процитировано

20
Green Tea and Benign Gynecologic Disorders: A New Trick for An Old Beverage? DOI Open Access
Dana Hazimeh, Gaelle Massoud, Maclaine Parish

и другие.

Nutrients, Год журнала: 2023, Номер 15(6), С. 1439 - 1439

Опубликована: Март 16, 2023

Green tea is harvested from the plant Camellia sinensis and one of most widely consumed beverages worldwide. It richer in antioxidants than other forms has a uniquely high content polyphenolic compounds known as catechins. Epigallocatechin-3-gallate (EGCG), major green catechin, been studied for its potential therapeutic role many disease contexts, including pathologies female reproductive system. As both prooxidant antioxidant, EGCG can modulate cellular pathways important to pathogenesis thus clinical benefits. This review provides synopsis current knowledge on beneficial effects benign gynecological disorders. alleviates symptom severity uterine fibroids improves endometriosis through anti-fibrotic, anti-angiogenic, pro-apoptotic mechanisms. Additionally, it reduce contractility improve generalized hyperalgesia associated with dysmenorrhea adenomyosis. Although infertility controversial, be used symptomatic treatment menopause, where decreases weight gain osteoporosis, well polycystic ovary syndrome (PCOS).

Язык: Английский

Процитировано

16
Dietary Polyphenols—Natural Bioactive Compounds with Potential for Preventing and Treating Some Allergic Conditions DOI Open Access
Anna Dębińska, Barbara Sozańska

Nutrients, Год журнала: 2023, Номер 15(22), С. 4823 - 4823

Опубликована: Ноя. 17, 2023

In light of the constantly increasing prevalence allergic diseases, changes in dietary patterns have been suggested as a plausible environmental explanation for development and progression these diseases. Nowadays, much attention has paid to interventions using natural substances with anti-allergy activities. this respect, polyphenols studied extensively one most prominent bioactive compounds well-documented anti-inflammatory, antioxidant, immunomodulatory properties. This review aims discuss mechanisms underlying potential anti-allergic actions related their ability reduce protein allergenicity, regulate immune response, gut microbiome modification; however, issues need be elucidated detail. paper reviews current evidence from experimental clinical studies confirming that various such quercetin, curcumin, resveratrol, catechins, many others could attenuate inflammation, alleviate symptoms food allergy, asthma, rhinitis, prevent response. Conclusively, are endowed great therefore used either preventive approaches or therapeutic relation Limitations studying widespread use well future research directions also discussed.

Язык: Английский

Процитировано

16