Synaptic promiscuity in brain development
Current Biology,
Год журнала:
2024,
Номер
34(3), С. R102 - R116
Опубликована: Фев. 1, 2024
Precise
synaptic
connectivity
is
a
prerequisite
for
the
function
of
neural
circuits,
yet
individual
neurons,
taken
out
their
developmental
context,
readily
form
unspecific
synapses.
How
does
genome
encode
brain
wiring
in
light
this
apparent
contradiction?
Synaptic
specificity
outcome
long
series
processes
and
mechanisms
before,
during
after
synapse
formation.
much
promiscuity
permissible
or
necessary
at
moment
partner
choice
depends
on
extent
to
which
prior
development
restricts
available
partners
subsequent
corrects
initially
made
can
thereby
play
important
roles
precise
connectivity,
but
also
facilitate
flexibility
robustness.
In
review,
we
assess
experimental
evidence
prevalence
promiscuous
formation
development.
Many
well-established
approaches
are
based
genetic
perturbation
an
assessment
only
adult;
make
it
difficult
pinpoint
when
given
defect
mechanism
occurred.
many
cases,
such
studies
reveal
that
restrict
availability
already
Subsequently,
choice,
factors
including
competency,
interaction
dynamics
molecular
recognition
further
partners.
The
discussion
through
lens
suggests
algorithmic
process
neurons
capable
continuously
prevented
from
making
wrong
choices,
with
no
single
time
point
sufficient
explain
outcome.
Язык: Английский
In vivo spontaneous Ca2+ activity in the pre-hearing mammalian cochlea
Nature Communications,
Год журнала:
2025,
Номер
16(1)
Опубликована: Янв. 2, 2025
Abstract
The
refinement
of
neural
circuits
towards
mature
function
is
driven
during
development
by
patterned
spontaneous
calcium-dependent
electrical
activity.
In
the
auditory
system,
this
sensory-independent
activity
arises
in
pre-hearing
cochlea
and
regulates
survival
pathway.
However,
origin
interplay
calcium
signals
cochlear
unknown
vivo.
Here
we
show
how
dynamics
neuroepithelium
live
mice
shape
inner
hair
cells
(IHCs)
their
afferent
synapses.
Both
IHCs
supporting
(SCs)
generate
Calcium
waves
from
SCs
synchronise
nearby
IHCs,
which
then
spreads
longitudinally
recruiting
several
additional
via
a
wave-independent
mechanism.
This
synchronised
IHC
vivo
increases
probability
terminal
recruitment.
Moreover,
modiolar-to-pillar
segregation
sound
sensitivity
nerve
fibres
appears
to
be
primed
at
ages.
Язык: Английский
Homeostatic plasticity in the retina
Progress in Retinal and Eye Research,
Год журнала:
2022,
Номер
94, С. 101131 - 101131
Опубликована: Окт. 13, 2022
Язык: Английский
Mechanisms driving the functional maturation of the developing mammalian auditory pathway
Current topics in developmental biology/Current Topics in Developmental Biology,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Mapping the Retina onto the Brain
Cold Spring Harbor Perspectives in Biology,
Год журнала:
2023,
Номер
16(2), С. a041512 - a041512
Опубликована: Дек. 5, 2023
Daniel
Kerschensteiner1,2,3
and
Marla
B.
Feller4,5
1Department
of
Ophthalmology
Visual
Sciences
2Department
Neuroscience
3Department
Biomedical
Engineering,
Washington
University
School
Medicine,
St.
Louis,
Missouri
63110,
USA
4Department
Molecular
Cell
Biology
5Helen
Wills
Institute,
California,
Berkeley,
California
94720,
Correspondence:
mfeller{at}berkeley.edu;
kerschensteinerd{at}wustl.edu
Язык: Английский
Visual Field Deficits in Albinism in Comparison to Idiopathic Infantile Nystagmus
Viral Sheth,
Rebecca J. McLean,
Zhanhan Tu
и другие.
Investigative Ophthalmology & Visual Science,
Год журнала:
2024,
Номер
65(2), С. 13 - 13
Опубликована: Фев. 6, 2024
Purpose:
This
is
the
first
systematic
comparison
of
visual
field
(VF)
deficits
in
people
with
albinism
(PwA)
and
idiopathic
infantile
nystagmus
(PwIIN)
using
static
perimetry.
We
also
compare
best-corrected
acuity
(BCVA)
optical
coherence
tomography
measures
fovea,
parafovea,
circumpapillary
retinal
nerve
fiber
layer
PwA.
Methods:
VF
testing
was
performed
on
62
PwA
36
PwIIN
a
Humphrey
Field
Analyzer
(SITA
FAST
24-2).
Mean
detection
thresholds
for
each
eye
were
calculated,
along
quadrants
central
measures.
Retinal
layers
manually
segmented
macular
region.
Results:
significantly
lower
than
normative
values
(−3.10
±
1.67
dB,
P
<<
0.0001)
(−1.70
1.54
<
0.0001).
compared
to
(P
worse
left
right
eyes
=
0.0002)
but
not
0.37).
In
PwA,
superior
nasal
other
0.05).
appeared
show
mild
relative
arcuate
scotoma.
correlated
foveal
changes
inner
outer
retina.
strongly
BCVA
both
groups.
Conclusions:
Clear
peripheral
exist
PwIIN,
results
need
be
interpreted
caution
clinically.
Since
exhibit
considerably
defects
are
unlikely
due
addition
horizontal
asymmetry,
vertical
interocular
asymmetries,
which
needs
further
exploration.
Язык: Английский
Large‐scale waves of activity in the neonatal mouse brain in vivo occur almost exclusively during sleep cycles
Developmental Neurobiology,
Год журнала:
2022,
Номер
82(7-8), С. 596 - 612
Опубликована: Окт. 1, 2022
Abstract
Spontaneous
electrical
activity
plays
major
roles
in
the
development
of
cortical
circuitry.
This
can
occur
highly
localized
regions
or
propagate
over
entire
cortex.
Both
types
coexist
during
early
development.
To
investigate
how
different
forms
spontaneous
might
be
temporally
segregated,
we
used
wide‐field
trans‐cranial
calcium
imaging
an
hemisphere
P1–P8
mouse
pups.
We
found
that
waves
to
cover
majority
cortex
(large‐scale
waves;
LSWs)
are
generated
at
end
first
postnatal
week,
along
with
several
other
more
activity.
further
LSWs
segregated
into
sleep
cycles.
In
contrast,
wake
states
is
spatially
restricted
and
few
large‐scale
distinguished
from
based
on
their
initiation
motor
correlation
body
movements.
change
functional
circuitry
a
state
permissive
for
may
segregate
critical
stages
when
activity‐dependent
circuit
occurs
many
spatial
scales.
Our
data
also
suggest
precursor
slow
adult,
which
play
memory
consolidation
synaptic
rescaling.
Язык: Английский
ERG Responses in Albinism, Idiopathic Infantile Nystagmus, and Controls
Investigative Ophthalmology & Visual Science,
Год журнала:
2024,
Номер
65(4), С. 11 - 11
Опубликована: Апрель 4, 2024
Our
primary
aim
was
to
compare
adult
full-field
ERG
(ffERG)
responses
in
albinism,
idiopathic
infantile
nystagmus
(IIN),
and
controls.
A
secondary
investigate
the
effect
of
within-subject
changes
eye
movements
on
ffERG
responses.
Язык: Английский
Development and Plasticity of Feature Selectivity
Oxford University Press eBooks,
Год журнала:
2023,
Номер
unknown, С. 545 - 553
Опубликована: Ноя. 23, 2023
Abstract
The
sensory
detectors
of
the
visual
system
are
built
through
mechanisms
that
depend
on
experience
individual
animal,
and
have
evolved
over
eons
evolution
but
do
not
animal.
Given
abilities
modern
deep-learning
systems
to
learn
from
examples,
one
might
imagine
a
large
fraction
be
purely
by
learning
example,
majority
receptive
field
properties
initially
formed
molecular
cues
activity-dependent
plasticity
depends
only
spontaneous
activity.
Even
some
features
require
animal
experience,
such
as
development
direction
selectivity
in
carnivores
primates,
largely
seeded
at
onset
like
preference
angle
very
malleable.
This
chapter
focuses
except
for
binocular
responses,
which
subject
Chapter
51
this
volume.
Язык: Английский