Linking tonic and phasic pupil responses to P300 amplitude in an emotional face‐word Stroop task

Psychophysiology, Год журнала: 2023, Номер 61(4)

Опубликована: Ноя. 2, 2023

Abstract The locus coeruleus‐norepinephrine (LC‐NE) system, which regulates arousal levels, is important for cognitive control, including emotional conflict resolution. Additionally, the LC‐NE system implicated in P300 generation. If mediated by and considering established correlations between LC activity pupil dilation, amplitude should correlate with task‐evoked (phasic) dilation on a trial‐by‐trial basis. However, prior studies, predominantly utilizing oddball‐type paradigms, have not demonstrated concurrently recorded responses. Using recently developed face‐word Stroop task that links to here, we examined both intra‐ inter‐individual amplitude. We found lower accuracy, slower reaction times, larger were obtained incongruent compared congruent condition. Furthermore, observed intra‐individual amplitude, correlating greater In contrast, did exhibit consistent N450 N170 amplitudes. Baseline (tonic) size also showed amplitudes, smaller corresponding Moreover, differences conditions correlated time though these effects only approached significance. To summarize, our study provides evidence connection at single‐trial level, suggesting involvement of

Язык: Английский

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Are the P600 and P3 ERP components linked to the task‐evoked pupillary response as a correlate of norepinephrine activity?

Psychophysiology, Год журнала: 2024, Номер 61(7)

Опубликована: Март 12, 2024

Abstract During language comprehension, anomalies and ambiguities in the input typically elicit P600 event‐related potential component. Although traditionally interpreted as a specific signal of combinatorial operations sentence processing, component has alternatively been proposed to be variant oddball‐sensitive, domain‐general P3 In particular, both components might reflect phasic norepinephrine release from locus coeruleus (LC/NE) motivationally significant stimuli. this preregistered study, we tested hypothesis by relating task‐evoked pupillary response, putative biomarker LC/NE activity. 36 participants completed comprehension task (containing 25% morphosyntactic violations) non‐linguistic oddball 20% oddballs), while EEG pupil size were co‐registered. Our results showed that response ERP amplitudes similarly affected experimental tasks. task, there was also temporally relationship between beyond shared effect, thereby further linking NE. Because link less reliable linguistic context, did not find conclusive evidence for or against response. Still, our findings stimulate debate on whether language‐related ERPs are indeed processes across cognitive domains. However, research is required verify two positivities system common neural generator.

Язык: Английский

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Altered pupil light and darkness reflex and eye-blink responses in late-life depression

BMC Geriatrics, Год журнала: 2024, Номер 24(1)

Опубликована: Июнь 24, 2024

Abstract Background Late-life depression (LLD) is a prevalent neuropsychiatric disorder in the older population. While LLD exhibits high mortality rates, depressive symptoms adults are often masked by physical health conditions. In younger adults, associated with deficits pupil light reflex and eye blink rate, suggesting potential use of these responses as biomarkers for LLD. Methods We conducted study using video-based eye-tracking to investigate patients ( n = 25), (OLD) healthy controls 29), (YOUNG) 25). The aim was determine whether there were alterations compared both OLD YOUNG groups. Results displayed significantly higher rates dampened constriction controls. tonic size differed from that OLD, did not exhibit significant difference GDS-15 scores correlated darkness response variability rates. PHQ-15 showed correlation while MoCA sizes. Conclusions findings demonstrate display altered behavior These differently severity depressive, somatic, cognitive symptoms, indicating their objective

Язык: Английский

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The forgotten wave of early pupillometry research

Trends in Neurosciences, Год журнала: 2024, Номер 47(8), С. 571 - 572

Опубликована: Авг. 1, 2024

Язык: Английский

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Pupil size correlates with heart rate, skin conductance, pulse wave amplitude, and respiration responses during emotional conflict and valence processing

Psychophysiology, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 12, 2024

Pupil size is a non-invasive index for autonomic arousal mediated by the locus coeruleus-norepinephrine (LC-NE) system. While pupil and its derivative (velocity) are increasingly used as indicators of arousal, limited research has investigated relationships between other well-known responses. Here, we simultaneously recorded pupillometry, heart rate, skin conductance, pulse wave amplitude, respiration signals during an emotional face-word Stroop task, in which task-evoked (phasic) dilation correlates with LC-NE responsivity. We hypothesized that conflict valence would affect responses, trial-by-trial correlations responses be observed both tonic phasic epochs. Larger dilations, higher derivative, lower rates were incongruent condition compared to congruent condition. Additionally, following trials, congruency effect was reduced, levels indexed previous-trial correlated subsequent reaction times. Furthermore, linear mixed models revealed larger dilations rates, conductance amplitudes, amplitudes on basis. Similar effects seen positive negative conditions. Moreover, before stimulus presentation significantly all whereas These results demonstrate relationship dynamics highlighting effective real-time processing.

Язык: Английский

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