bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 27, 2024
Abstract
Pregnancy
and
motherhood
(parity)
can
have
long-term
effects
on
cognition
brain
aging
in
both
humans
rodents.
Estrogens
are
related
to
cognitive
function
neuroplasticity.
improve
postmenopausal
women,
but
the
evidence
is
mixed,
part
due
differences
hormone
therapy
dose
composition.
In
addition,
past
pregnancy
influences
cognition,
with
earlier
age
of
first
being
associated
poorer
outcomes
aging.
However,
few
studies
examined
specific
features
history
such
as
or
possible
mechanisms
underlying
these
changes.
We
whether
maternal
at
estradiol
treatment
differentially
affected
hippocampal
neuroplasticity,
inflammation,
activation,
middle-age.
Thirteen-month-old
rats
(who
were
nulliparous
(never
mothered)
previously
primiparous
(had
a
litter)
3
months
7
months)
received
daily
injections
(or
sesame
oil
vehicle)
for
sixteen
days
tested
Morris
Water
Maze.
An
older
was
impaired
spatial
memory
improved
performance
reversal
training,
increased
new
neurons
ventral
hippocampus
compared
other
groups.
Estradiol
decreased
total
activation
percent
dorsal
hippocampus,
regardless
parity
history.
also
production
anti-inflammatory
cytokines
based
pregnancy.
This
work
suggests
that
affects
neuroplasticity
neuroinflammation
middle
age,
long
lasting
structure
function.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2023,
Номер
unknown
Опубликована: Июль 13, 2023
Abstract
Female
sex
and
Apolipoprotein
E
(APOE)
ε4
genotype
are
top
non-modifiable
risk
factors
for
Alzheimer’s
disease
(AD).
Although
female-unique
experiences
like
parity
(pregnancy
motherhood)
have
positive
effects
on
neuroplasticity
at
middle
age,
previous
pregnancy
may
also
contribute
to
AD
risk.
To
explore
these
seemingly
paradoxical
long-term
of
parity,
we
investigated
the
impact
with
APOEε4
by
examining
behavioural
neural
biomarkers
brain
health
in
middle-aged
female
rats.
Our
findings
show
that
primiparous
(parous
one
time)
hAPOEε4
rats
display
increased
use
a
non-spatial
cognitive
strategy
exhibit
decreased
number
recruitment
new-born
neurons
ventral
dentate
gyrus
hippocampus
response
spatial
working
memory
retrieval.
Furthermore,
primiparity
synergistically
modulate
neuroinflammatory
markers
hippocampus.
Collectively,
demonstrate
confers
an
added
present
reduced
activity
engagement
as
well
elevated
pro-inflammatory
signaling,
underscores
importance
considering
female-specific
research.
Highlights
made
more
errors
used
Primiparous
Parity
neurogenesis
wildtype
rats,
but
it
had
less
active
new
retrieval
affect
neuroimmune
milieu
region-specific
manner
Human Brain Mapping,
Год журнала:
2023,
Номер
45(1)
Опубликована: Дек. 8, 2023
Abstract
Surgical
menopause
causes
a
sharp
drop
in
estrogen
levels
middle‐aged
women,
thus
preventing
the
gradual
physiological
adaptation
that
is
characteristic
of
perimenopause.
Previous
studies
suggest
surgical
might
increase
risk
dementia
later
life.
In
addition,
transition
to
motherhood
entails
long‐lasting
endocrine
and
neuronal
adaptations.
We
compared
differences
whole‐brain
cortical
volume
between
women
who
reached
by
surgery
group
spontaneous
non‐surgical
determined
whether
these
were
influenced
previous
childbearing.
Using
surface‐based
neuroimaging
techniques,
we
investigated
201
(134
experienced
menopause,
78
whom
parous
women;
67
39
women).
found
significant
atrophy
frontal
temporal
regions
menopause.
Nulliparous
with
showed
lower
left
gyrus
extending
medial
lobe
cortex,
as
well
precuneus
bilaterally
menopause;
whereas
our
results
revealed
no
both
nulliparous
Furthermore,
group,
negative
correlation
age
at
first
pregnancy
lobe.
Our
study
suggests
long‐term
brain
remodeling
parity
may
mitigate
neural
impact
sudden
characterizes
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 27, 2024
Abstract
Pregnancy
and
motherhood
(parity)
can
have
long-term
effects
on
cognition
brain
aging
in
both
humans
rodents.
Estrogens
are
related
to
cognitive
function
neuroplasticity.
improve
postmenopausal
women,
but
the
evidence
is
mixed,
part
due
differences
hormone
therapy
dose
composition.
In
addition,
past
pregnancy
influences
cognition,
with
earlier
age
of
first
being
associated
poorer
outcomes
aging.
However,
few
studies
examined
specific
features
history
such
as
or
possible
mechanisms
underlying
these
changes.
We
whether
maternal
at
estradiol
treatment
differentially
affected
hippocampal
neuroplasticity,
inflammation,
activation,
middle-age.
Thirteen-month-old
rats
(who
were
nulliparous
(never
mothered)
previously
primiparous
(had
a
litter)
3
months
7
months)
received
daily
injections
(or
sesame
oil
vehicle)
for
sixteen
days
tested
Morris
Water
Maze.
An
older
was
impaired
spatial
memory
improved
performance
reversal
training,
increased
new
neurons
ventral
hippocampus
compared
other
groups.
Estradiol
decreased
total
activation
percent
dorsal
hippocampus,
regardless
parity
history.
also
production
anti-inflammatory
cytokines
based
pregnancy.
This
work
suggests
that
affects
neuroplasticity
neuroinflammation
middle
age,
long
lasting
structure
function.
