Human Brain Mapping,
Journal Year:
2023,
Volume and Issue:
45(1)
Published: Dec. 8, 2023
Abstract
Surgical
menopause
causes
a
sharp
drop
in
estrogen
levels
middle‐aged
women,
thus
preventing
the
gradual
physiological
adaptation
that
is
characteristic
of
perimenopause.
Previous
studies
suggest
surgical
might
increase
risk
dementia
later
life.
In
addition,
transition
to
motherhood
entails
long‐lasting
endocrine
and
neuronal
adaptations.
We
compared
differences
whole‐brain
cortical
volume
between
women
who
reached
by
surgery
group
spontaneous
non‐surgical
determined
whether
these
were
influenced
previous
childbearing.
Using
surface‐based
neuroimaging
techniques,
we
investigated
201
(134
experienced
menopause,
78
whom
parous
women;
67
39
women).
found
significant
atrophy
frontal
temporal
regions
menopause.
Nulliparous
with
showed
lower
left
gyrus
extending
medial
lobe
cortex,
as
well
precuneus
bilaterally
menopause;
whereas
our
results
revealed
no
both
nulliparous
Furthermore,
group,
negative
correlation
age
at
first
pregnancy
lobe.
Our
study
suggests
long‐term
brain
remodeling
parity
may
mitigate
neural
impact
sudden
characterizes
Frontiers in Veterinary Science,
Journal Year:
2024,
Volume and Issue:
11
Published: June 27, 2024
Maternal
behavior
research
in
laboratory
rats
has
revealed
important
behavioral
and
neurobiological
mechanisms
governing
the
onset,
maintenance
decline
of
maternal
behavior.
However,
extent
to
which
these
are
evolutionarily
conserved
across
species
is
less
clear.
This
manuscript
proposes
that
examining
dogs
may
be
a
viable
approach
test
their
generality
help
bridge
gap
between
rodent
human
research,
as
domestic
show
greater
individual
differences
exhibit
more
human-like
characteristics
than
rodents.
These
aspects
represent
advantages
over
models,
turn
allow
systems
biological
approaches
not
available
Additionally,
share
similar
social
environments
with
humans,
suffer
from
same
mental
disorders
can
treated
medications.
paper
begins
summary
key
findings
theoretical
developments
decades
rat
followed
by
literature
review
extant
on
related
methodology,
highlighting
unique
dog
similarities
Finally,
several
knowledge
gaps
well
future
this
area
discussed.
It
concludes
will
only
advance
our
understanding
universality
behavior,
but
also
improve
risk
factors
associated
postpartum
disorders.
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2023,
Volume and Issue:
unknown
Published: July 13, 2023
Abstract
Female
sex
and
Apolipoprotein
E
(APOE)
ε4
genotype
are
top
non-modifiable
risk
factors
for
Alzheimer’s
disease
(AD).
Although
female-unique
experiences
like
parity
(pregnancy
motherhood)
have
positive
effects
on
neuroplasticity
at
middle
age,
previous
pregnancy
may
also
contribute
to
AD
risk.
To
explore
these
seemingly
paradoxical
long-term
of
parity,
we
investigated
the
impact
with
APOEε4
by
examining
behavioural
neural
biomarkers
brain
health
in
middle-aged
female
rats.
Our
findings
show
that
primiparous
(parous
one
time)
hAPOEε4
rats
display
increased
use
a
non-spatial
cognitive
strategy
exhibit
decreased
number
recruitment
new-born
neurons
ventral
dentate
gyrus
hippocampus
response
spatial
working
memory
retrieval.
Furthermore,
primiparity
synergistically
modulate
neuroinflammatory
markers
hippocampus.
Collectively,
demonstrate
confers
an
added
present
reduced
activity
engagement
as
well
elevated
pro-inflammatory
signaling,
underscores
importance
considering
female-specific
research.
Highlights
made
more
errors
used
Primiparous
Parity
neurogenesis
wildtype
rats,
but
it
had
less
active
new
retrieval
affect
neuroimmune
milieu
region-specific
manner
Human Brain Mapping,
Journal Year:
2023,
Volume and Issue:
45(1)
Published: Dec. 8, 2023
Abstract
Surgical
menopause
causes
a
sharp
drop
in
estrogen
levels
middle‐aged
women,
thus
preventing
the
gradual
physiological
adaptation
that
is
characteristic
of
perimenopause.
Previous
studies
suggest
surgical
might
increase
risk
dementia
later
life.
In
addition,
transition
to
motherhood
entails
long‐lasting
endocrine
and
neuronal
adaptations.
We
compared
differences
whole‐brain
cortical
volume
between
women
who
reached
by
surgery
group
spontaneous
non‐surgical
determined
whether
these
were
influenced
previous
childbearing.
Using
surface‐based
neuroimaging
techniques,
we
investigated
201
(134
experienced
menopause,
78
whom
parous
women;
67
39
women).
found
significant
atrophy
frontal
temporal
regions
menopause.
Nulliparous
with
showed
lower
left
gyrus
extending
medial
lobe
cortex,
as
well
precuneus
bilaterally
menopause;
whereas
our
results
revealed
no
both
nulliparous
Furthermore,
group,
negative
correlation
age
at
first
pregnancy
lobe.
Our
study
suggests
long‐term
brain
remodeling
parity
may
mitigate
neural
impact
sudden
characterizes
