SLAS TECHNOLOGY, Год журнала: 2024, Номер unknown, С. 100212 - 100212
Опубликована: Окт. 1, 2024
Heat shock proteins (HSPs) play a critical role in cellular stress responses and have been implicated numerous diseases, including Parkinson's disease (PD) various cancers. Understanding the differential expression functional implications of HSPs these conditions is crucial for identifying potential therapeutic targets biomarkers diagnosis prognosis.
Язык: Английский
Brain Sciences, Год журнала: 2023, Номер 14(1), С. 19 - 19
Опубликована: Дек. 23, 2023
The term “neuroinflammation” defines the typical inflammatory response of brain closely related to onset many neurodegenerative diseases (NDs). Neuroinflammation is well known, but its mechanisms and pathways are not entirely comprehended. Some progresses have been achieved through efforts research. Consequently, new cellular molecular mechanisms, diverse conventional, emerging. In listing some those that will be subject our description discussion, essential important roles peripheral infiltrated monocytes clonotypic cells, alterations in gut–brain axis, dysregulation apelinergic system, endothelial glycocalyx component neuronal vascular units, variations expression genes levels encoding molecules by action microRNAs (miRNAs), or other epigenetic factors distinctive transcriptional factors, as role autophagy, ferroptosis, sex differences, modifications circadian cycle. Such can add significantly understanding complex etiological puzzle neuroinflammation ND. addition, they could represent biomarkers targets ND, which increasing elderly.
Язык: Английский
Процитировано
23
European Journal of Neurology, Год журнала: 2025, Номер 32(1)
Опубликована: Янв. 1, 2025
Abstract Background Several studies evaluated peripheral and cerebrospinal fluid (CSF) mtDNA as a putative biomarker in neurodegenerative diseases, often yielding inconsistent findings. We systematically reviewed the current evidence assessing blood CSF levels variant burden Parkinson's disease (PD), Alzheimer's (AD) amyotrophic lateral sclerosis (ALS). Multiple (MS) was also included paradigm of chronic neuroinflammation‐driven neurodegeneration. Methods Medline, Embase, Scopus Web Science were searched for articles published from inception until October 2023. Studies focused on haplogroups or hereditary pathogenic variants excluded. Critical appraisal performed using Quality Assessment Diagnostic Accuracy criteria. Results Fifty‐nine original met our priori‐defined inclusion The majority CSF‐focused showed (i) decreased PD AD; (ii) increased MS compared to controls. No ALS. cell‐free intracellular contradictory, even within evaluating same disease. This poor reproducibility is likely due lack consideration many factors known affect levels. damage methylation reduced patients controls, respectively. A few investigated correlation between severity, with conflicting results. Conclusions Additional well‐designed are needed evaluate profiles biomarkers diseases. identification “mitochondrial subtypes” may enable novel precision medicine strategies counteract
Язык: Английский
Процитировано
1
Journal of Inflammation Research, Год журнала: 2024, Номер Volume 17, С. 3259 - 3282
Опубликована: Май 1, 2024
The coronavirus disease 2019 (COVID-19) can lead to neurological symptoms such as headaches, confusion, seizures, hearing loss, and loss of smell. link between COVID-19 Parkinson's (PD) is being investigated, but more research needed for a definitive connection.
Язык: Английский
Процитировано
5
Frontiers in Cellular Neuroscience, Год журнала: 2024, Номер 18
Опубликована: Июль 26, 2024
Parkinson’s disease (PD) is a prevalent neurodegenerative disorder that affects the central nervous system (CNS). Neuroinflammation crucial factor in pathological advancement of PD. PD characterized by presence activated microglia and increased levels proinflammatory factors, which play role its pathology. During immune response PD, regulation significantly influenced microRNA (miRNA). The excessive activation microglia, persistent neuroinflammation, abnormal polarization macrophages brain can be attributed to dysregulation certain miRNAs. Additionally, there are miRNAs possess ability inhibit neuroinflammation. miRNAs, small non-coding epigenetic regulators, have modulate microglial activity both normal conditions. They also significant impact on promoting communication between neurons microglia.
Язык: Английский
Процитировано
5
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(23), С. 16766 - 16766
Опубликована: Ноя. 26, 2023
Recent research has unveiled intriguing insights suggesting that the body’s immune system may be implicated in Parkinson’s disease (PD) development. Studies have observed disparities pro-inflammatory and anti-inflammatory markers between PD patients healthy individuals. This finding underscores potential influence of dysfunction genesis this condition. A dysfunctional can serve as a primary catalyst for systemic inflammation body, which contribute to emergence various brain disorders. The identification several genes associated with PD, well their connection neuroinflammation, raises likelihood susceptibility. Moreover, advancing age mitochondrial weaken system, potentially implicating them onset disease, particularly among older Compromised integrity blood–brain barrier could facilitate system’s access tissue. exposure lead encounters native antigens or infections, triggering an autoimmune response. Furthermore, there is mounting evidence supporting notion gut dysbiosis might represent initial trigger inflammation, ultimately promoting neurodegeneration. In comprehensive review, we will delve into numerous hypotheses surrounding role both innate adaptive immunity PD.
Язык: Английский
Процитировано
10
Опубликована: Ноя. 27, 2023
With the term neuroinflammation has defined typical inflammatory response of brain closely related to onset many neurological diseases. Neuroinflammation is well known, but its mechanisms and pathways are not entirely comprehended. Currently, some progress been achieved through efforts research. Consequently, new cellular molecular mecha-nisms, diverse from conventional ones, emerging. In listing those that will be sub-ject our description discussion, essential important role peripheral infiltrated monocytes clonotypic cells, alterations in gut/brain axis, dysregulation apelinergic sys-tem, as changes endothelial glycocalyx blood-brain barrier, variation expres-sion genes levels encoding molecules by microRNAs (miRNAs), or other epige-netic factors distinctive transcriptional factors, autophagy, ferroptosis, sex differences modifications circadian cycle. Such mentioned can add significant pieces understanding complex etiological puzzle neuroinflammation. addi-tion, they could represent biomarkers targets neurodegenerative diseases, increase old populations.
Язык: Английский
Процитировано
10
Parkinsonism & Related Disorders, Год журнала: 2024, Номер 123, С. 106102 - 106102
Опубликована: Март 16, 2024
Язык: Английский
Процитировано
4
Pharmacological Research, Год журнала: 2024, Номер 203, С. 107168 - 107168
Опубликована: Апрель 5, 2024
Parkinson's disease (PD) is a common neurodegenerative characterized by progressive loss of dopaminergic neurons in the substantia nigra and aggregation alpha-synuclein (α-syn). The central nervous system (CNS) has previously been considered as an immune-privileged area. However, studies have shown that immune responses are involved PD. major histocompatibility complex (MHC) presents antigens from Antigen-presenting cells(APCs) to T lymphocytes, will be induced. MHCs expressed microglia, astrocytes, neurons. Single nucleotide polymorphisms MHC related risk aggregated α-syn triggers expression activating glia cells. CD4+ CD8+ lymphocytes microglia activation detected brains PD patients. In addiction further increase blood-brain barrier (BBB) permeability cell infiltration Thus, through participating inflammatory responses.
Язык: Английский
Процитировано
4
Neurobiology of Disease, Год журнала: 2024, Номер 200, С. 106609 - 106609
Опубликована: Июль 22, 2024
Gastrointestinal dysfunction has emerged as a prominent early feature of Parkinson's Disease, shedding new light on the pivotal role enteric nervous system in its pathophysiology. However, immune-cell clusters and inflammatory glial markers gut pathogenetic process needs further elucidation.
Язык: Английский
Процитировано
4
npj Parkinson s Disease, Год журнала: 2024, Номер 10(1)
Опубликована: Ноя. 5, 2024
Abstract Increasing efforts have been made to elucidate how genetic and environmental factors interact in Parkinson’s disease (PD). In the present study, we assessed development of symptoms on a PD rat model that overexpresses human α-synuclein ( Snca +/+ ) at presymptomatic age, exposed pro-inflammatory insult by intraperitoneal injection lipopolysaccharide (LPS), using immunohistology, high-dimensional flow cytometry, constant potential amperometry, behavioral analyses. A single LPS into WT rats triggered long-lasting increase activation microglial markers, monocytes, T lymphocytes. However, only showed dopaminergic neuronal loss substantia nigra pars compacta (SNpc), associated with reduction release evoked dopamine striatum. No significant changes were observed domain. We propose our double-hit animal as reliable investigate mechanisms whereby inflammation promote neurodegeneration PD.
Язык: Английский
Процитировано
4