Review of microRNAs and lncRNAs in atherosclerosis, diabetes, and other inflammatory conditions DOI Open Access
Jernej Letonja, Daniel Petrovič

Опубликована: Ноя. 17, 2023

It is generally accepted that atherosclerosis a chronic inflammatory disease. The link between and other diseases such as psoriasis, type 2 diabetes mellitus (T2DM), rheumatoid arthritis (RA) via metabolic, inflammatory, immunoregulatory pathways well established. aim of our review was to summarize the associations selected microRNAs (miRs) long non-coding RNAs (lncRNAs) atherosclerosis, T2DM, RA. MicroRNAs are short noncoding RNA molecules involved in cell signaling, intracellular communication, gene expression. We reviewed role miR-146a, miR-210, miR-143, miR-223, miR-126, miR-21, miR-155, miR-145, miR-200, miR-133, miR-135, miR-221, miR-424, let-7 LncRNAs transcripts longer than 200 nucleotides cellular processes apoptosis, metabolism, inflammation, differentiation, proliferation. evaluated lncRNA-H19, lncRNA-MEG3, lncRNA-UCA1, lncRNA-XIST Extracellular vesicles (EVs) method signal transduction. Their function depends on surface expression, cargo, from which they originate.

Язык: Английский

A Review of MicroRNAs and lncRNAs in Atherosclerosis as Well as Some Major Inflammatory Conditions Affecting Atherosclerosis DOI Creative Commons
Jernej Letonja, Daniel Petrovič

Biomedicines, Год журнала: 2024, Номер 12(6), С. 1322 - 1322

Опубликована: Июнь 13, 2024

It is generally accepted that atherosclerosis a chronic inflammatory disease. The link between and other diseases such as psoriasis, type 2 diabetes mellitus (T2DM), rheumatoid arthritis (RA) via metabolic, inflammatory, immunoregulatory pathways well established. aim of our review was to summarize the associations selected microRNAs (miRs) long non-coding RNAs (lncRNAs) atherosclerosis, T2DM, RA. We reviewed role miR-146a, miR-210, miR-143, miR-223, miR-126, miR-21, miR-155, miR-145, miR-200, miR-133, miR-135, miR-221, miR-424, let-7, lncRNA-H19, lncRNA-MEG3, lncRNA-UCA1, lncRNA-XIST in Extracellular vesicles (EVs) are method intracellular signal transduction. Their function depends on surface expression, cargo, cell from which they originate. majority studies investigated lncRNAs some miRs had relatively small sample sizes, limits generalizability their findings indicates need for more research. Based reviewed, lncRNA-H19 most promising potential biomarkers and, possibly, therapeutic targets RA, psoriasis.

Язык: Английский

Процитировано

4
Trichodenoids A and B, Two Skeletally Unprecedented Polyketides from Trichoderma reesei with Cardioprotective Effects against H2O2-Induced Injury DOI
Rui Jiang, Jiayi Guo, Shenglan Yang

и другие.

Journal of Agricultural and Food Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Март 6, 2025

Trichoderma reesei, recognized by the FDA as a food-safe strain, plays vital role in food fermentation. Although enzymatic applications of T. reesei are well-established, health benefits its fermentation-derived metabolites yet to be fully explored. Trichodenoids A (1) and B (2), two skeletally unprecedented polyketides, were isolated from endophytic fungus originating plant Gastrodia elata Blume. Their structures elucidated via spectroscopic data, single-crystal X-ray crystallographic analysis, quantum chemical DP4+ ECD calculation. Compounds 1 2 uniquely defined unusual 6/6/5 6/6/5/6 ring systems, respectively, which proposed formed through key Diels-Alder Baeyer-Villiger reactions during biosynthesis. Compound had potential mitigate H2O2-induced oxidative stress H9C2 cells reducing intracellular ROS levels, restoring mitochondrial function, regulating mRNA expression related stress, inflammation, autophagy. These findings highlight compound candidate for natural antioxidants even dietary supplements cardiovascular health.

Язык: Английский

Процитировано

0
Transforming Cardiotoxicity Detection in Cancer Therapies: The Promise of MicroRNAs as Precision Biomarkers DOI Open Access
Isabel Moscoso, Moisés Rodríguez‐Mañero, María Cebro-Márquez

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(22), С. 11910 - 11910

Опубликована: Ноя. 6, 2024

Cardiotoxicity (CDTX) is a critical side effect of many cancer therapies, leading to increased morbidity and mortality if not addressed. Early detection CDTX essential, while echocardiographic measures like global longitudinal strain offer promise in identifying early myocardial dysfunction, the search for reliable biomarkers continues. MicroRNAs (miRNAs) are emerging as important non-coding RNA molecules that regulate gene expression post-transcriptionally, influencing key biological processes such cell cycle, apoptosis, stress responses. In cardiovascular diseases, miRNAs have demonstrated potential due their stability circulation specific patterns reflect pathological changes. Certain been linked hold detection, prognosis, therapeutic targeting. These only assist cardiac injury, but also opportunities personalized interventions by modulating influence disease progression. As research advances, integrating miRNA profiling with traditional diagnostic methods could enhance management patients, paving way improved patient outcomes more tailored strategies. Further clinical studies essential validate utility managing CDTX.

Язык: Английский

Процитировано

1
Deciphering the roles of cellular and extracellular non-coding RNAs in chemotherapy-induced cardiotoxicity DOI Creative Commons
Feng Pan, Fan Yang, Dae Young Zang

и другие.

Molecular and Cellular Biochemistry, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 1, 2024

Chemotherapy-induced cardiotoxicity is a major adverse effect, driven by multiple factors in its pathogenesis. Notably, RNAs have emerged as significant contributors both cancer and heart failure (HF). carry genetic metabolic information that mirrors the current state of cells, making them valuable potential biomarkers therapeutic tools for diagnosing, predicting, treating range diseases, including cardiotoxicity. Over 97% genome transcribed into non-coding (ncRNAs), ribosomal RNA (rRNAs), transfer (tRNAs), newly identified microRNAs (miRNAs), circular (circRNAs), long (lncRNAs). NcRNAs function not only within their originating cells but also recipient being transported through extracellular compartments, referred to (exRNAs). Since ncRNAs were key regulators gene expression, numerous studies highlighted significance cardiovascular diseases. Nevertheless, role remains fully elucidated. The study aims review existing knowledge on Cardio-Oncology explore ncRNA-based therapies. These investigations could advance clinical application ncRNA research, improving early detection mitigating chemotherapy-induced

Язык: Английский

Процитировано

0
Review of microRNAs and lncRNAs in atherosclerosis, diabetes, and other inflammatory conditions DOI Open Access
Jernej Letonja, Daniel Petrovič

Опубликована: Ноя. 17, 2023

It is generally accepted that atherosclerosis a chronic inflammatory disease. The link between and other diseases such as psoriasis, type 2 diabetes mellitus (T2DM), rheumatoid arthritis (RA) via metabolic, inflammatory, immunoregulatory pathways well established. aim of our review was to summarize the associations selected microRNAs (miRs) long non-coding RNAs (lncRNAs) atherosclerosis, T2DM, RA. MicroRNAs are short noncoding RNA molecules involved in cell signaling, intracellular communication, gene expression. We reviewed role miR-146a, miR-210, miR-143, miR-223, miR-126, miR-21, miR-155, miR-145, miR-200, miR-133, miR-135, miR-221, miR-424, let-7 LncRNAs transcripts longer than 200 nucleotides cellular processes apoptosis, metabolism, inflammation, differentiation, proliferation. evaluated lncRNA-H19, lncRNA-MEG3, lncRNA-UCA1, lncRNA-XIST Extracellular vesicles (EVs) method signal transduction. Their function depends on surface expression, cargo, from which they originate.

Язык: Английский

Процитировано

1