Nano-alumina
(AlNPs)
is
widely
used
because
of
its
unique
physicochemical
properties.
AlNPs
can
be
released
directly
or
indirectly
into
the
environment,
causing
extensive
exposure
and
potential
harm
to
humans.
Exposure
may
impair
learning
memory,
but
toxicity
not
fully
understood.
Studies
have
shown
that
cause
neurotoxic
neurodevelopmental
toxic
effects.
In
this
chapter,
we
investigate
neurotoxicity
particles
their
effects
on
mitochondria
autophagy.
This
series
studies
provide
clear
mechanisms
therapeutic
directions
for
induced
by
AlNPs.
Food Chemistry Advances,
Год журнала:
2022,
Номер
1, С. 100135 - 100135
Опубликована: Окт. 1, 2022
Global
food
waste
is
the
biggest
issue
owing
to
spoilage.
According
world
program,
approx.
35
million
people
worldwide
suffer
from
acute
malnutrition.
Despite
this,
modern
civilization
has
a
significant
problem
with
pollution
spurred
by
synthetic
plastics
(SPs).
So,
natural
polymers
are
essential
in
reducing
spoilage
and
this
planet.
Therefore,
biodegradable/edible
films
coatings
have
drawn
much
attention.
This
review
paper
primarily
emphasizes
addresses
historical
perspective,
various
types
of
(NPs)
their
application
packaging
industries,
environmental
concerns,
cold
plasma
technology
nanotechnology
prospects
biodegradable
employed
production
edible
packaging.
In
study,
polysaccharides
proteins
that
been
considered.
Currently,
materials
gaining
popularity
these
days
because
pollutants
produced
improper
disposal
plastic
packaging,
usage
increased.
However,
advantageous
properties
for
development
they
biodegradable,
biocompatible,
minimal
toxicity
properties.
such
as
induced
modify
film
mechanical,
physical,
chemical,
barrier.
Consequently,
may
be
combined
produce
wide
range
composite
excellent
mechanical
biological
properties,
making
them
suitable
Ecotoxicology and Environmental Safety,
Год журнала:
2024,
Номер
273, С. 116100 - 116100
Опубликована: Фев. 16, 2024
Chlorothalonil
(CTL)
is
widely
used
in
agricultural
production
and
antifoulant
additive
globally
due
to
its
broad
spectrum
non-systemic
properties,
resulting
widespread
existence
foods,
soil
water.
Extensive
evidence
demonstrated
that
exposure
CTL
induced
adverse
effects
on
organisms
particular
reproductive
toxicity
has
been
attracted
public
concern.
However,
the
influences
of
oocyte
maturation
mysterious
so
far.
In
this
study,
we
documented
toxic
vitro
related
underlying
mechanisms.
Exposure
caused
continuous
activation
spindle
assembly
checkpoints
(SAC)
which
turn
compromised
meiotic
mouse
oocyte,
featured
by
attenuation
polar
body
extrusion
(PBE).
Detection
cytoskeletal
dynamics
weakened
acetylation
level
α-tubulin
impaired
apparatus,
was
responsible
for
aberrant
state
SAC.
Meanwhile,
damaged
function
mitochondria,
inducing
decline
ATP
content
elevation
reactive
oxygen
species
(ROS),
thereby
early
apoptosis
DNA
damage
oocytes.
addition,
alteration
histone
H3
methylation,
indicative
harmful
epigenetic
modifications
Further,
CTL-induced
oxidative
stress
activated
mitogen-activated
protein
kinase
(MAPK)
pathway
injured
summary,
via
destroying
assembly,
triggering
MAPK
activation.
Ecotoxicology and Environmental Safety,
Год журнала:
2022,
Номер
236, С. 113467 - 113467
Опубликована: Апрель 4, 2022
The
epidemiological
studies
regarding
perfluorooctanoic
acid
(PFOA)
suggests
that
its
exposure
causes
reproductive
health
issues,
the
underlying
mechanisms
of
which
are
still
in
infancy.
Here,
we
report
PFOA
deteriorates
female
reproduction
at
multiple
development
stages.
Oocyte
meiosis
and
preimplantation
severely
impaired
by
with
oxidative
stress
being
a
contributor.
Supplementing
antioxidant
melatonin
partially
rescues
oocyte
meiotic
maturation
non-apoptotic
demise.
attenuation
ovarian
follicle
however
can
be
improved
metformin
but
not
melatonin.
Importantly,
blunts
PFOA-induced
fetal
growth
retardation
(FGR)
such
protective
effect
could
recapitulated
transplantation
fecal
material
pharmacological
activation
AMPK.
Mechanistically,
gut
microbiota
dysbiosis,
might
thereby
rewire
host
metabolism
L-phenylalanine,
histamine
L-palmitoylcarnitine
triggers
hyperphenylalaninaemia,
inflammation
ferroptosis
to
initiate
FGR.
Deregulated
serine
microbe
constitutes
an
alternative
mechanism
FGR
modulation
dam's
diet
phenocopied
Our
study
expands
understanding
risk
factors
impair
human
health,
proposes
restoration
diversity
intervention
as
therapeutics
mitigating
risks
predisposed
environmental
perturbation.
Frontiers in Physiology,
Год журнала:
2023,
Номер
14
Опубликована: Авг. 4, 2023
There
has
been
a
global
decline
in
fertility
rates,
with
ovulatory
disorders
emerging
as
the
leading
cause,
contributing
to
lifetime
infertility
prevalence
of
17.5%.
Formation
primordial
follicle
pool
during
early
and
further
development
oocytes
after
puberty
is
crucial
determining
female
reproductive
quality.
However,
increasing
exposure
environmental
toxins
(through
occupational
ubiquitous
chemicals)
daily
life
growing
concern;
these
have
identified
significant
risk
factors
for
oogenesis
women.
In
light
this
concern,
review
aims
enhance
our
understanding
system
diseases
their
implications.
Specifically,
we
summarized
categorized
that
can
affect
oogenesis.
Here,
provide
an
overview
oogenesis,
highlighting
specific
stages
may
be
susceptible
influence
toxins.
Furthermore,
discuss
genetic
molecular
mechanisms
by
which
various
toxins,
including
metals,
cigarette
smoke,
agricultural
industrial
Raising
awareness
about
potential
risks
associated
toxin
crucial.
research
needed
fully
comprehend
underlying
effects,
identification
biomarkers
assess
levels
predict
outcomes.
By
providing
comprehensive
overview,
contribute
better
impact
on
guide
future
field.
Ecotoxicology and Environmental Safety,
Год журнала:
2025,
Номер
289, С. 117595 - 117595
Опубликована: Янв. 1, 2025
3-methyl-4-nitrophenol
(PNMC),
a
chemical
prevalent
in
various
industries
for
drug,
dye,
and
leather
production,
also
serves
as
primary
byproduct
of
organophosphate
insecticides.
Despite
its
global
recognition
an
endocrine
disruptor
with
documented
reproductive
toxicity,
detrimental
impact
on
preimplantation
embryonic
development
has
yet
to
be
thoroughly
investigated.
In
this
study,
through
the
vitro
culture
mice
embryos,
it
was
initially
observed
that
even
low
concentrations
PNMC
exposure
led
significant
reduction
blastocyst
formation
sharp
decline
ratio
inner
cell
mass
within
blastocysts.
SMART-seq2
transcriptome
sequencing
further
confirmed
treatment
disrupted
gene
expression
2-cell
differentially
expressed
genes
enriched
multiple
signaling
pathways,
including
those
related
autophagy,
apoptosis,
fertilization,
development,
transcription,
mRNA
processing.
Integration
data
open
databases
revealed
both
zygotic
genome
activation
maternal
factors
experienced
transcript-level
disruptions.
Moreover,
study
demonstrated
these
changes
were
closely
associated
mitochondrial
dysfunction,
evidenced
by
diminished
membrane
potential,
reduced
ATP
aberrant
mitochondria-related
genes,
increased
ROS
accumulation,
heightened
DNA
damage
PNMC-treated
embryos.
Additionally,
induced
defects
histone
modification,
shown
altered
levels
H3K9me3
H3K27me3,
H3K9ac
H3K27ac.
Lastly,
findings
indicated
triggered
apoptosis
validated
elevated
BAX
CASPASE3
expression,
alongside
positive
TUNEL
staining.
summary,
impairs
maternal-to-zygotic
transition,
likely
dysfunction
culminating
developmental
arrest
mouse
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Фев. 25, 2025
Mixed
lineage
kinase
domain-like
protein
(MLKL)
is
a
pseudokinase
featured
by
kinase-like
domain
without
catalytic
activity.
MLKL
was
originally
discovered
to
be
phosphorylated
receptor-interacting
1/3,
typically
increase
plasma
membrane
permeabilization,
and
disrupt
the
integrity,
ultimately
executing
necroptosis.
Recent
evidence
uncovers
association
of
with
diverse
cellular
organelles,
including
mitochondrion,
lysosome,
endosome,
endoplasmic
reticulum,
nucleus.
Thus,
this
review
mainly
focuses
on
regulatory
functions,
mechanisms,
targets
in
organelles
rather
than
necroptosis
summarize
medical
significance
multiple
diseases.
On
basis,
we
conclude
analyze
current
progress
prospect
for
development
MLKL-related
drugs,
from
natural
products,
small-molecule
chemical
compounds,
proteolysis-targeting
chimera.
This
aimed
propel
as
valid
drug
target
discovery
novel
promote
their
further
applications.
