Biosensors and Bioelectronics, Год журнала: 2024, Номер 271, С. 117043 - 117043
Опубликована: Дек. 6, 2024
Язык: Английский
Biosensors and Bioelectronics, Год журнала: 2024, Номер 271, С. 117043 - 117043
Опубликована: Дек. 6, 2024
Язык: Английский
Translational Oncology, Год журнала: 2024, Номер 50, С. 102121 - 102121
Опубликована: Сен. 14, 2024
Язык: Английский
Процитировано
60Science and Technology of Advanced Materials, Год журнала: 2024, Номер 25(1)
Опубликована: Апрель 22, 2024
Exosomes, a type of extracellular vesicles, have attracted considerable attention due to their ability provide valuable insights into the pathophysiological microenvironment cells from which they originate. This characteristic implicates potential use as diagnostic disease biomarkers clinically, including cancer, infectious diseases, neurodegenerative disorders, and cardiovascular diseases. Aptasensors, are electrochemical aptamers based biosensing devices, emerged new class powerful detection technology conventional methods like ELISA Western analysis, primarily because capability for high-performance bioanalysis. review covers current research landscape on exosomes utilizing nanoarchitectonics strategy development aptasensors. Strategies involving signal amplification biofouling prevention discussed, with an emphasis nanoarchitectonics-based bio-interfaces, showcasing enhance sensitivity selectivity through optimal conduction mass transport properties. The ongoing challenges broaden clinical applications these biosensors also highlighted.
Язык: Английский
Процитировано
17Biomarker Research, Год журнала: 2024, Номер 12(1)
Опубликована: Дек. 5, 2024
Abstract Early detection of cancer significantly improves patient outcomes, with biomarkers offering a promising avenue for earlier and more precise diagnoses. Microfluidic biosensors have emerged as powerful tool detecting these in body fluids, providing enhanced sensitivity, specificity, rapid analysis. This review focuses on recent advances microfluidic from 2018 to 2024, detailing their operational principles, fabrication techniques, integration nanotechnology biomarker detection. Additionally, we reviewed innovations several aspects biosensors, such novel technologies, nanomaterials chip structures, which enhance capabilities. We highlight key pertinent early explore how biosensor technology contribute the evolving landscape personalized medicine. further technologies could be incorporated into clinical diagnostic workflows improve treatment outcomes. These help enable diagnostics. In addition, this addresses important issues enhancing scalability sensitivity settings points out future possibilities combining artificial intelligence diagnostics optimize practical applications. overview aims guide research applications by addressing current challenges identifying opportunities development field research.
Язык: Английский
Процитировано
16Analytical Chemistry, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 17, 2024
Cancer-derived exosomes carry a large number of specific molecular profiles from cancer cells and have emerged as ideal biomarkers for early diagnosis. Accurate detection ultralow-abundance in complex biological samples remains great challenge. Herein, novel SERS aptasensor powered by cascaded signal amplification CRISPR/Cas13a
Язык: Английский
Процитировано
8Analytical Chemistry, Год журнала: 2024, Номер 96(32), С. 13299 - 13307
Опубликована: Авг. 2, 2024
Exosomes have received considerable attention as potent reference markers for the diagnosis of various neoplasms due to their close and direct relationship with proliferation, adhesion, migration tumor. The ultrasensitive detection cancer-derived low-abundance exosomes is imperative, but still a great challenge. Herein, we report an electrochemiluminescence (ECL) biosensor based on DNA-bio-bar-code hybridization chain reaction (HCR)-mediated dual signal amplification exosomes. In this system, two types aptamers were modified magnetic nanoprobe (MNPs) gold nanoparticles (AuNPs) numerous bio-bar-code DNA, respectively, which formed "sandwich" structures in presence specific target separated under field, DNA released by dissolving AuNPs. triggered HCR procedure produce good deal long duplex structure embedding hemin, generated strong ECL coreactors Under optimal conditions, it exhibited linearly ranging from 10
Язык: Английский
Процитировано
6Biosensors and Bioelectronics, Год журнала: 2024, Номер 267, С. 116737 - 116737
Опубликована: Сен. 4, 2024
Язык: Английский
Процитировано
6Analytica Chimica Acta, Год журнала: 2025, Номер 1344, С. 343709 - 343709
Опубликована: Янв. 23, 2025
Язык: Английский
Процитировано
0Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0Microchemical Journal, Год журнала: 2025, Номер unknown, С. 113477 - 113477
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0Biosensors and Bioelectronics, Год журнала: 2025, Номер 282, С. 117497 - 117497
Опубликована: Апрель 18, 2025
Язык: Английский
Процитировано
0