Investigating the role of exosomal long non-coding RNAs in drug resistance within female reproductive system cancers
Frontiers in Cell and Developmental Biology,
Год журнала:
2025,
Номер
13
Опубликована: Янв. 24, 2025
Exosomes,
as
key
mediators
of
intercellular
communication,
have
been
increasingly
recognized
for
their
role
in
the
oncogenic
processes,
particularly
facilitating
drug
resistance.
This
article
delves
into
emerging
evidence
linking
exosomal
lncRNAs
to
modulation
resistance
mechanisms
cancers
such
ovarian,
cervical,
and
endometrial
cancer.
It
synthesizes
current
research
findings
on
how
these
influence
cancer
cell
survival,
tumor
microenvironment,
chemotherapy
efficacy.
Additionally,
review
highlights
potential
therapeutic
strategies
targeting
lncRNAs,
proposing
a
new
frontier
overcoming
By
mapping
interface
resistance,
this
aims
provide
comprehensive
understanding
that
could
pave
way
innovative
treatments
improved
patient
outcomes
female
reproductive
system
cancers.
Язык: Английский
Role of Triple‐Negative Breast Cancer‐Derived Extracellular Vesicles in Metastasis: Implications for Therapeutics and Biomarker Development
Journal of Cellular and Molecular Medicine,
Год журнала:
2025,
Номер
29(5)
Опубликована: Март 1, 2025
Triple-negative
breast
cancer
(TNBC)
is
a
highly
aggressive
form
of
with
poor
prognosis
and
high
mortality.
The
chemotherapeutic
regimen
remains
the
predominant
treatment
modality
for
TNBC
in
current
clinical
practice.
However,
chemotherapy
resistance
significantly
complicates
development
an
effective
regimen.
Furthermore,
immunosuppressive
microenvironment
contributes
to
enhanced
tumour
aggressiveness.
Consequently,
understanding
its
mechanisms
progression
finding
therapeutic
interventions
crucial.
Recent
evidence
has
identified
extracellular
vesicles
(EVs)
as
key
mediators
cell-to-cell
communication
immune
regulation.
In
view
remarkable
ability
EVs
transfer
active
molecules,
such
proteins
nucleic
acids,
from
parental
recipient
cells,
they
are
regarded
promising
biomarker
novel
drug
delivery
system.
this
review,
we
provide
overview
how
derived
cells
play
role
regulating
progression.
We
also
discuss
potential
regulation
their
application
strategies
markers
TNBC.
knowledge
gained
studying
EV-mediated
could
lead
targeted
therapies
improve
patient
outcomes.
Язык: Английский
The multiple functions and mechanisms of long non-coding RNAs in regulating breast cancer progression
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Март 28, 2025
Breast
cancer
(BC)
is
a
malignant
tumor
that
has
the
highest
morbidity
and
mortality
rates
in
female
population,
its
high
tendency
to
metastasize
main
cause
of
poor
clinical
prognosis.
Long
non-coding
RNAs
(lncRNAs)
have
been
extensively
documented
exhibit
aberrant
expression
various
cancers
influence
progression
via
multiple
molecular
pathways.
These
lncRNAs
not
only
modulate
numerous
aspects
gene
cells,
such
as
transcription,
translation,
post-translational
modifications,
but
also
play
crucial
role
reprogramming
energy
metabolism
by
regulating
metabolic
regulators,
which
particularly
significant
advanced
BC.
This
review
examines
characteristics
mechanisms
BC
both
intracellularly
(e.g.,
cell
cycle,
autophagy)
extracellularly
microenvironment).
Furthermore,
we
explore
potential
specific
their
regulatory
factors
markers
therapeutic
targets.
Lastly,
summarize
application
treatment
BC,
aiming
offer
novel
personalized
options
for
patients.
Язык: Английский
Tumor cell extracellular vesicles derived long non-coding RNA X-inactive specific transcript regulates the blood–brain barrier and non-small cell lung cancer brain metastasis via miR-19b-3p/EPN2
Heliyon,
Год журнала:
2024,
Номер
unknown, С. e40152 - e40152
Опубликована: Ноя. 1, 2024
Язык: Английский