Investigating the role of exosomal long non-coding RNAs in drug resistance within female reproductive system cancers

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13

Published: Jan. 24, 2025

Exosomes, as key mediators of intercellular communication, have been increasingly recognized for their role in the oncogenic processes, particularly facilitating drug resistance. This article delves into emerging evidence linking exosomal lncRNAs to modulation resistance mechanisms cancers such ovarian, cervical, and endometrial cancer. It synthesizes current research findings on how these influence cancer cell survival, tumor microenvironment, chemotherapy efficacy. Additionally, review highlights potential therapeutic strategies targeting lncRNAs, proposing a new frontier overcoming By mapping interface resistance, this aims provide comprehensive understanding that could pave way innovative treatments improved patient outcomes female reproductive system cancers.

Language: Английский

---

Role of Triple‐Negative Breast Cancer‐Derived Extracellular Vesicles in Metastasis: Implications for Therapeutics and Biomarker Development

Journal of Cellular and Molecular Medicine, Journal Year: 2025, Volume and Issue: 29(5)

Published: March 1, 2025

Triple-negative breast cancer (TNBC) is a highly aggressive form of with poor prognosis and high mortality. The chemotherapeutic regimen remains the predominant treatment modality for TNBC in current clinical practice. However, chemotherapy resistance significantly complicates development an effective regimen. Furthermore, immunosuppressive microenvironment contributes to enhanced tumour aggressiveness. Consequently, understanding its mechanisms progression finding therapeutic interventions crucial. Recent evidence has identified extracellular vesicles (EVs) as key mediators cell-to-cell communication immune regulation. In view remarkable ability EVs transfer active molecules, such proteins nucleic acids, from parental recipient cells, they are regarded promising biomarker novel drug delivery system. this review, we provide overview how derived cells play role regulating progression. We also discuss potential regulation their application strategies markers TNBC. knowledge gained studying EV-mediated could lead targeted therapies improve patient outcomes.

Language: Английский

---

The multiple functions and mechanisms of long non-coding RNAs in regulating breast cancer progression

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: March 28, 2025

Breast cancer (BC) is a malignant tumor that has the highest morbidity and mortality rates in female population, its high tendency to metastasize main cause of poor clinical prognosis. Long non-coding RNAs (lncRNAs) have been extensively documented exhibit aberrant expression various cancers influence progression via multiple molecular pathways. These lncRNAs not only modulate numerous aspects gene cells, such as transcription, translation, post-translational modifications, but also play crucial role reprogramming energy metabolism by regulating metabolic regulators, which particularly significant advanced BC. This review examines characteristics mechanisms BC both intracellularly (e.g., cell cycle, autophagy) extracellularly microenvironment). Furthermore, we explore potential specific their regulatory factors markers therapeutic targets. Lastly, summarize application treatment BC, aiming offer novel personalized options for patients.

Language: Английский

---

Tumor cell extracellular vesicles derived long non-coding RNA X-inactive specific transcript regulates the blood–brain barrier and non-small cell lung cancer brain metastasis via miR-19b-3p/EPN2

Heliyon, Journal Year: 2024, Volume and Issue: unknown, P. e40152 - e40152

Published: Nov. 1, 2024

Language: Английский

---